Results 161 to 170 of about 29,033 (245)

Immunosenescence and inflammaging in Parkinson's disease: mechanisms and therapeutic prospects. [PDF]

Front Immunol
Yan R, Feng H, Zhang J.
europepmc   +1 more source

Altered Cytokine‐Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine‐Non‐Responsiveness in Aging and HIV

Aging Cell, Volume 25, Issue 3, March 2026.
Chronic immune activation and inflammation associated with aging and HIV skew Tfh signaling toward enhanced IL‐2–STAT5 activation, reinforcing IL‐2R expression through a positive feedback loop and suppressing Tfh helper differentiation programs, thereby contributing to impaired vaccine responsiveness.
Sheldon Davis, Jonah Kupritz, Prabhsimran Singh, Savita Pahwa, Suresh Pallikkuth   +4 more
wiley   +1 more source

Age-related changes in circulating immune factors reveal biomarkers of immunosenescence. [PDF]

Front Med (Lausanne)
Zhang X, Xu S, Ye L, Yin J, Zhang M, Jin Y, Li J.   +6 more
europepmc   +1 more source

Physical Fitness Dynamics Shape Immune Remodeling in Healthy Aging: A 3‐Year Longitudinal Study

Aging Cell, Volume 25, Issue 3, March 2026.
In a 3‐year longitudinal study of healthy older adults, intraindividual declines in physical fitness and strength were linked to dynamic immune remodeling, including shifts toward senescent and regulatory T cell phenotypes, despite stable activity levels.
Christopher Weyh, Vincent Größer, Luciele Guerra Minuzzi, Torsten Frech, Kristina Gebhardt, Svenja Nolte, Theresa Dombrowski, Manuela Andrea Hoffmann, Natascha Sommer, Robert Ringseis, Klaus Eder, Samuel Sossalla, Pascal Bauer, Karsten Krüger   +13 more
wiley   +1 more source

Immunosenescence and Allergy: Molecular and Cellular Links Between Inflammaging, Neuro-Immune Aging, and Response to Biologic Therapies. [PDF]

Int J Mol Sci
Aitella E, Azzellino G, Cammisuli BA, De Benedictis C, Di Mattia D, Romano C, Ginaldi L, De Martinis M.   +7 more
europepmc   +1 more source

Magnesium Deficiency Accelerates Gut Aging and Increases Susceptibility to Colitis

Aging Cell, Volume 25, Issue 3, March 2026.
Aging is associated with a gut‐specific decline in magnesium (Mg), which accelerates intestinal aging and aggravates colitis in aged mice. Mechanistically, Mg deficiency reshapes the phosphoproteome and N‐glycoproteome, destabilizing adhesion complexes.
Rou Zhang, Meiling Ge, Meng Hu, Yanjie Zhao, Baochen Chong, Wanmeng Li, Jia Yu, Ying Lu, Siyu He, Jiao Wang, Jirong Yue, Hai‐Ning Chen, Heng Xu, Yong Peng, Peng Lei, Zuyun Liu, Lunzhi Dai   +16 more
wiley   +1 more source

Latent Toxoplasma gondii Infection Does Not Modulate Immune Aging in a Cross-Sectional Working-Age Population Study. [PDF]

Biomolecules
Bröde P, Claus M, Getzmann S, Golka K, Hengstler JG, Reinders J, Wascher E, Watzl C, Gajewski PD.   +8 more
europepmc   +1 more source

Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer. [PDF]

Front Immunol
Liu X, Liu B, Tong Y, Zhu X, Sang Y, Gao F, Niu X, Tang Y, Xu K, Chen H, Chong W, Li L.   +11 more
europepmc   +1 more source

Alemtuzumab Induction in Septuagenarians Undergoing Deceased Donor Kidney Transplantation

Clinical Transplantation, Volume 40, Issue 3, March 2026.
ABSTRACT Introduction The anti‐CD52 monoclonal antibody alemtuzumab is used as an induction agent in kidney transplantation (KT) but remains understudied in septuagenarian recipients. The study purpose was to analyze the safety and efficacy of single‐dose alemtuzumab induction in septuagenarian deceased donor (DD) KT recipients.
David I. Harriman, Alex Ng, Alan C. Farney, Giuseppe Orlando, Colleen Jay, Amber Reeves‐Daniel, Robert J. Stratta   +6 more
wiley   +1 more source

Exercise Ameliorates Immunosenescence: From Mechanisms to Interventions. [PDF]

Biology (Basel)
Xiao H, Ren J.
europepmc   +1 more source