Results 211 to 220 of about 521,863 (391)

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

open access: yesAdvanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma   +9 more
wiley   +1 more source

Discovery to Engineering of Mycotoxin Deoxynivalenol Degrading Enzymes Based on the Specialized Glyoxalase I

open access: yesAdvanced Science, EarlyView.
Deoxynivalenol (DON), a prevalent food mycotoxin, is an important risk factor in global food safety. A molecular phylogeny‐guided engineering approach is devised to repurpose specialized glyoxalase I (SPG) as a DON deactivator. Engineered SPG variants demonstrate superior stability and are highly capable of converting DON into less toxic products ...
Seung Hee Lee   +12 more
wiley   +1 more source

IMMUNOSUPPRESSION WITH AZATHIOPRINE, PREDNISONE, AND CYCLOPHOSPHAMIDE1

open access: bronze, 1979
John Jeffery   +3 more
openalex   +1 more source

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