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Comparisons Between Frontline Therapy and a Combination of Eltrombopag Plus Immunosuppression Therapy and Human Leukocyte Antigen-Haploidentical Hematopoietic Stem Cell Transplantation in Patients With Severe Aplastic Anemia: A Systematic Review [PDF]

Frontiers in Oncology, 2021
Background and Aims: This study aimed at comparing the efficacy and safety of eltrombopag (EPAG) plus immunosuppressive therapies (ISTs) and haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in the frontline treatment for severe ...
Yuan Yang, Jiang Ji, Zengwei Tang, Bing Han   +3 more
doaj   +4 more sources

BK polyomavirus-associated nephropathy [PDF]

Childhood Kidney Diseases, 2022
BK polyomavirus (BKPyV) is a ubiquitous virus residing in the kidney tubules and is clinically significant only in immunocompromised patients. In clinical practice, BKPyV is a causative pathogen of BKPyV-associated nephropathy (BKVAN) in kidney allograft
Yo Han Ahn, Hee Gyung Kang
doaj   +1 more source

Dialysis Dependency at Discharge in De Novo ANCA Associated Renal Limited Vasculitis: Should We Avoid Further Immunosuppression?

Revista Portuguesa de Nefrologia e Hipertensão, 2022
Introduction: ANCA associated vasculitis commonly affects the kidneys. The intense inflammatory damage disrupts the glomerular architecture. Induction immunosuppressive therapy is responsible for a large part of the morbidity and mortality of these ...
Rui Filipe Nogueira, Nuno Afonso Oliveira, Margarida Gaudêncio, Ana Belmira, Rui Alves   +4 more
doaj   +1 more source

Monoclonal antibody‐mediated immunosuppression enables long‐term survival of transplanted human neural stem cells in mouse brain

Clinical and Translational Medicine, 2022
Background As the field of stem cell therapy advances, it is important to develop reliable methods to overcome host immune responses in animal models. This ensures survival of transplanted human stem cell grafts and enables predictive efficacy testing ...
Lisa M. McGinley, Kevin S. Chen, Shayna N. Mason, Diana M. Rigan, Jacquelin F. Kwentus, John M. Hayes, Emily D. Glass, Evan L. Reynolds, Geoffrey G. Murphy, Eva L. Feldman   +9 more
doaj   +1 more source

COVID-19 as Another Trigger for HBV Reactivation: Clinical Case and Review of Literature

Pathogens, 2022
Universal hepatitis B virus (HBV) vaccination has been applied for years in most countries, but HBV infection remains an unresolved public health problem worldwide, with over one-third of the world’s population infected during their lifetime and ...
Caterina Sagnelli, Laura Montella, Pierantonio Grimaldi, Mariantonietta Pisaturo, Loredana Alessio, Stefania De Pascalis, Evangelista Sagnelli, Nicola Coppola   +7 more
doaj   +1 more source

Orthotopic Liver Transplantation of a SARS-CoV-2 Negative Recipient from a Positive Donor: The Border between Uncertainty and Necessity in a Pandemic Era- Case Report and Overview of the Literature

Medicina, 2023
(1) Introduction: Liver transplantation represents the gold-standard therapy in eligible patients with acute liver failure or end-stage liver disease.
Gabriela Droc, Cristina Martac, Cristina Georgiana Buzatu, Miruna Jipa, Maria Daniela Punga, Sebastian Isac   +5 more
doaj   +1 more source

Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management

Frontiers in Medicine, 2022
In recent years, immunotherapy has become an important pillar of cancer treatment, with high response rates regardless of tumor histology or baseline mutations, sometime in patients without any alternative of treatment.
Virginia Robles-Alonso, Fernando Martínez-Valle, Natalia Borruel, Natalia Borruel   +3 more
doaj   +1 more source

Case Report: A Case Series of Immunobiological Therapy (Anti-TNF-α) for Patients With Erythema Nodosum Leprosum

Frontiers in Medicine, 2022
Patients with leprosy may experience a chronic and severe type II leprosy reaction (ENL) erythema nodosum leprosum that may not respond to thalidomide and systemic immunosuppressants or may even cause serious adverse events. We here present four patients
Ana Flávia Moura Mendes, Ciro Martins Gomes, Patrícia Shu Kurizky, Mayra Ianhez, Mayra Ianhez   +4 more
doaj   +1 more source

Pediatric Liver Transplantation: Then and Now [PDF]

, 2020
This paper reviews the past 50 years of liver transplantation in children from the perspective of patient demographics, perioperative patient management, surgical techniques, immunosuppression and patient ...
Banh, DPT, Carullo, PC, Davis, PJ, Tran, LT, Vitu, C   +4 more
core   +1 more source

Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum [PDF]

Clinical and Experimental Pediatrics, 2020
Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder.
Joo Hee Seo, Yun-Jin Lee, Ki Hyeong Lee, Elakkat Gireesh, Holly Skinner, Michael Westerveld   +5 more
doaj   +1 more source