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Immunosuppressive Therapy in Myocarditis
Circulation Journal, 2014 Although there is general agreement on the favorable effect of immunosuppression in eosinophilic, granulomatous, giant-cell myocarditis and in lymphocytic myocarditis associated with connective tissue disorders and with rejection of a transplanted heart, its therapeutic role in lymphocytic inflammatory cardiomyopathy (ICM) is still debated.
FRUSTACI, ANDREA, CHIMENTI, CRISTINA
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Mathematical model for delayed responses in immune checkpoint blockades [PDF]
Bulletin of Mathematical Biology, 83: 106 (2021), 2021 We introduce a set of ordinary differential equations (ODE) that qualitatively reproduces delayed responses observed in immune checkpoint blockade therapy (e.g. anti-CTLA-4 Ipilimumab). This type of immunotherapy has been at the forefront of novel and promising cancer treatments over the past decade and was recognised by the 2018 Nobel Prize in ...
arxiv +1 more source
Immunosuppressive Drug Therapy [PDF]
Cold Spring Harbor Perspectives in Medicine, 2013 The first successful kidney transplantation between monozygotic identical twins did not require any immunosuppressive drugs. Clinical application of azathioprine and glucocorticosteroids allowed the transfer of organs between genetically disparate donors and recipients.
Manikkam Suthanthiran +2 more
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Cellular Therapies for Immunosuppression [PDF]
, 2012 Almost all current therapeutic approaches to inhibit destructive immune responses in autoimmunity are based on antigen non-specific agents, such as cyclosporine A, which systemically suppress the function of virtually all immune effector cells.
Cools, Nathalie +2 more
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Immunosuppressive therapy in polymyositis [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1971 Immunosuppressive drugs were given to seven patients with polymyositis. The in-vitro activity of peripheral blood lymphocytes had previously been studied in five of these patients with findings suggestive of disturbed immunological processes. Some improvement occurred in five cases, but only in two was the improvement marked and sustained.
S. Currie, J. N. Walton
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Quantitative Methods for Optimizing Patient Outcomes in Liver Transplantation [PDF]
arXiv, 2023 Liver transplantation continues to be the gold standard for treating patients with end-stage liver diseases. However, despite the huge success of liver transplantation in improving patient outcomes, long term graft survival continues to be a major problem.
arxiv
Immunosuppressive therapy in dermatology and PML [PDF]
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2008 Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating disease of the central nervous system that usually leads to death or severe disability. Affected patients present with signs and symptoms including impaired cognition, visual disturbances, hemiparesis, altered mental state and behavioural changes.
Sterry, Wolfram +5 more
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Repurposing immunosuppressants for antileukemia therapy
EMBO Molecular Medicine, 2022 Drug repurposing, the strategy to identify new therapeutic use for clinically approved drugs has attracted much attention in recent years. This strategy offers various advantages over traditional approaches to develop new drugs, including shorter development timelines, low cost, and reduced risk of failure. In this issue of EMBO Molecular Medicine, Liu
Maiko Sezaki, Gang Huang
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Addressing current challenges in cancer immunotherapy with mathematical and computational modeling [PDF]
Journal of the Royal Society Interface, 14 (131): 20170150 (2017), 2017 The goal of cancer immunotherapy is to boost a patient's immune response to a tumor. Yet, the design of an effective immunotherapy is complicated by various factors, including a potentially immunosuppressive tumor microenvironment, immune-modulating effects of conventional treatments, and therapy-related toxicities.
arxiv +1 more source
Deep learning approach to describe and classify fungi microscopic images [PDF]
, 2020 Preliminary diagnosis of fungal infections can rely on microscopic examination. However, in many cases, it does not allow unambiguous identification of the species by microbiologist due to their visual similarity. Therefore, it is usually necessary to use additional biochemical tests.
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