Results 111 to 120 of about 213,546 (300)

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Modern immunosuppression

, 2017
\ua9 2017. Organ transplantation provides both life-saving and life-enhancing function for patients suffering from end-stage organ failure. Transplantation has only been possible due to the advances in immunosuppression.
Wilson C, Figueiredo RS
core  

Photodynamic Therapy–Induced Immunosuppression in Humans Is Prevented by Reducing the Rate of Light Delivery

, 2011
Photodynamic therapy (PDT) of non-melanoma skin cancers currently carries failure rates of 10–40%. The optimal irradiation protocol is as yet unclear.
Georgia A. Frost, Halliday, Gary M., Gary M. Halliday, Damian, Diona L., Diona L. Damian, Frost, Georgia A.   +5 more
core   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Cancer outcomes in patients requiring immunosuppression in addition to corticosteroids for immune‐related adverse events after immune checkpoint inhibitor therapy

, 2020
AIM:To examine the cancer-specific outcomes for patients who experience immune-related adverse events requiring immunosuppression beyond corticosteroids.
Burdett, N., Hsu, K., Brown, M.P., Kerri Beckmann, Xiong, L., Beckmann, K., Libo Xiong, Tapia-Rico, G., Michael P. Brown, Karapetis, C., Nikki Burdett, Gonzalo Tapia‐Rico, Kristin Hsu, Christos Karapetis   +13 more
core   +1 more source

Therapy-related acute myeloid leukaemia following immunosuppression with azathioprine for polymyositis [PDF]

, 1994
A 52-year-old man developed therapy-related acute myeloid leukemia (AML) following prolonged immunosuppression with azathioprine for polymyositis. Karyotypic analysis showed deletions of the short arm of chromosome 7 and the long arm of chromosome 5. The
Krishnan, Koyamangalath, Dabich, Lyubica, Adams, Paul, Sheldon, Susan, Silveira, Scott   +4 more
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice

, 2009
Background: Adeno-associated virus serotype 2 (AAV2) vectors show considerable promise for ocular gene transfer. However, one potential barrier to efficacious long-term therapy is the development of immune responses against the vector or transgene ...
Ali, R.R., Buch, P, Barker, S.E., Robbie, S.J., Natkunarajah, M, Maclaren, Robert, Broderick, CA, Smith, A.J., Natkunarajah, M., Duran, Y, Buch, P., Ali, RR, Maclaren, RE, Balaggan, K.S., Duran, Y., MacLaren, R.E., Bainbridge, J.W. B., Bainbridge, JW, Barker, SE, Broderick, C.A., Robbie, SJ, Balaggan, KS, Smith, AJ   +22 more
core   +1 more source

Autoimmune Inner Ear Disease from a Rheumatologic Perspective

Diagnostics
Background/Objectives: Autoimmune inner ear disease (AIED) causes sensorineural hearing loss that classically presents as fluctuating, asymmetric loss of hearing. Associated vestibular and other ear symptoms can be present in many patients.
Maximiliano Diaz-Menindez, Ana-Maria Chindris, Carolyn Mead-Harvey, Yan Li, Ronald R. Butendieck, Razvan M. Chirila, Katherine L. Britt, Florentina Berianu   +7 more
doaj   +1 more source

CD4 counts and the risk of systemic non-Hodgkin’s lymphoma in individuals with HIV in the UK

Haematologica, 2009
Since the introduction of highly active antiretroviral therapy, there has been a decline in the incidence of non-Hodgkin’s lymphoma among HIV-infected individuals.
Mark Bower, Martin Fisher, Teresa Hill, Iain Reeves, John Walsh, Chloe Orkin, Andrew N. Phillips, Loveleen Bansi, Richard Gilson, Philippa Easterbrook, Margaret Johnson, Brian Gazzard, Clifford Leen, Deenan Pillay, Achim Schwenk, Jane Anderson, Kholoud Porter, Mark Gompels, Caroline A. Sabin, for the UK CHIC Steering Committee   +19 more
doaj   +1 more source