Results 41 to 50 of about 4,619,877 (335)

Immunosuppressive therapy in dermatology and PML [PDF]

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2008
Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating disease of the central nervous system that usually leads to death or severe disability. Affected patients present with signs and symptoms including impaired cognition, visual disturbances, hemiparesis, altered mental state and behavioural changes.
Sterry, Wolfram, Bagot, Martine, Ferrandiz, Carlos, Kragballe, Knud, Papp, Kim, Stingl, Georg   +5 more
openaire   +4 more sources

Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Nature Cancer, 2022
Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that favors cancer progression, therapy resistance and immune evasion.
Federica Cappellesso, Marie-Pauline Orban, Niranjan Shirgaonkar, E. Berardi, J. Serneels, Marie-Aline C. Neveu, Daria Di Molfetta, Francesca Piccapane, R. Caroppo, L. Debellis, Tessa Ostyn, N. Joudiou, Lionel Mignion, Elena Richiardone, B. Jordan, B. Gallez, C. Corbet, T. Roskams, R. Dasgupta, S. Tejpar, Mario Di Matteo, D. Taverna, S. Reshkin, B. Topal, Federico Virga, M. Mazzone   +25 more
semanticscholar   +1 more source

Repurposing immunosuppressants for antileukemia therapy

EMBO Molecular Medicine, 2022
Drug repurposing, the strategy to identify new therapeutic use for clinically approved drugs has attracted much attention in recent years. This strategy offers various advantages over traditional approaches to develop new drugs, including shorter development timelines, low cost, and reduced risk of failure. In this issue of EMBO Molecular Medicine, Liu
Maiko Sezaki, Gang Huang
openaire   +3 more sources

A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy

International Journal of Cancer, 2018
YAP1 is one of the most important effectors of the Hippo pathway and has crosstalk with other cancer promoting pathways. YAP1 contributes to cancer development in various ways that include promoting malignant phenotypes, expansion of cancer stem cells ...
M. Shibata, Kendall Ham, M. Hoque
semanticscholar   +1 more source

Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression

Annals of the Rheumatic Diseases, 2021
Objective There is an urgent need to assess the impact of immunosuppressive therapies on the immunogenicity and efficacy of SARS-CoV-2 vaccination. Methods Serological and T-cell ELISpot assays were used to assess the response to first-dose and second ...
M. Prendecki, C. Clarke, Helena Edwards, Stacey McIntyre, P. Mortimer, S. Gleeson, P. Martin, T. Thomson, P. Randell, Anand Shah, A. Singanayagam, L. Lightstone, A. Cox, P. Kelleher, M. Willicombe, S. McAdoo   +15 more
semanticscholar   +1 more source

Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression

Science Translational Medicine, 2019
Immune checkpoints can be targeted using exogenous reagents or via genetic modification to enhance the efficacy of adoptive T cell therapy. The development of new cancer immunotherapies including checkpoint blockade and chimeric antigen receptor (CAR) T ...
Sherly Mardiana, B. Solomon, P. Darcy, P. Beavis   +3 more
semanticscholar   +1 more source

Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series

BMC Infectious Diseases, 2019
BackgroundThe sepsis-induced immunodepression contributes to impaired clinical outcomes of various stress conditions. This syndrome is well documented and characterized by attenuated function of innate and adaptive immune cells.
D. Payen, V. Faivre, J. Miatello, J. Leentjens, C. Brumpt, P. Tissières, C. Dupuis, P. Pickkers, A. Lukaszewicz   +8 more
semanticscholar   +1 more source

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

Frontiers in Immunology, 2018
Clinical and technological advances promoting early hemorrhage control and physiologic resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly decreased in-hospital mortality for many critically ill patient populations.
Hiroyuki Horiguchi, T. Loftus, Russell B. Hawkins, Steven L. Raymond, Julie A. Stortz, Mckenzie Hollen, Brett Weiss, Elizabeth S. Miller, A. Bihorac, S. Larson, A. Mohr, S. Brakenridge, H. Tsujimoto, H. Ueno, F. Moore, L. Moldawer, P. Efron   +16 more
semanticscholar   +1 more source

Immunogenicity and toxicity of AAV gene therapy

Frontiers in Immunology, 2022
Gene transfer using adeno-associated viral (AAV) vectors has made tremendous progress in the last decade and has achieved cures of debilitating diseases such as hemophilia A and B.
H. Ertl
semanticscholar   +1 more source

Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy

Nature Communications, 2022
Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in hepatocellular carcinoma (HCC) and other cancers, mediated in part by the immunosuppressive tumor microenvironment (TME).
Yuling Xiao, Jiang Chen, Hui Zhou, Xiaodong Zeng, Z. Ruan, Zhangya Pu, Xingya Jiang, A. Matsui, Lingling Zhu, Zohreh Amoozgar, Dean Shuailin Chen, Xiangfei Han, D. Duda, Jinjun Shi   +13 more
semanticscholar   +1 more source