Results 41 to 50 of about 4,676,099 (307)

Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]

, 2012
The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
Abboudi, H, Macphee, IA
core   +2 more sources

Impact of COVID-19 on patients treated with autologous hematopoietic stem cell transplantation: A retrospective cohort study

Upsala Journal of Medical Sciences, 2022
Objective: To describe how coronavirus disease 2019 (COVID-19) affects patients with hematological malignancies treated with autologous hematopoietic stem cell transplantation (ASCT).
Thomas Silfverberg, Björn Wahlin, Kristina Carlson, Honar Cherif   +3 more
doaj   +1 more source

Impact of B Cell Depletion on COVID-19 in Kidney Transplant Recipients

Viruses, 2023
Kidney transplant recipients are patients at high risk for coronavirus disease 2019 (COVID-19) due to being on immunosuppressive therapy. B cell depletion therapy, including rituximab, is an important strategy for ABO-incompatible transplants.
Naohiro Aida, Taihei Ito, Kei Kurihara, Izumi Hiratsuka, Megumi Shibata, Atsushi Suzuki, Midori Hasegawa, Takashi Kenmochi   +7 more
doaj   +1 more source

Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence. [PDF]

, 2016
Aspergillus spp. are a group of filamentous molds that were first described due to a perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when viewed under a microscope.
Stewart, Ethan R, Thompson, George R
core   +3 more sources

Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression

International Journal of Molecular Sciences, 2022
Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product.
Lihua Chen, Lixiang Huang, Yu Gu, W. Cang, P. Sun, Yang Xiang   +5 more
semanticscholar   +1 more source

Reactivation of Tumor-like Chagas Disease in the Central Nervous System in Cardiac Transplant Patients: A Case Series and Literature Review

Brazilian Neurosurgery, 2023
Introduction Chagas disease is an important public health problem in Latin American countries, affecting ∼ 6 million people within the region.
Antônio Gilson Prates Júnior, Fernando Augusto Medeiros Carrera Macedo, José Augusto Malheiros, Maria Letícia Marques Pinheiro, Lucas Rodrigues de Souza, Ana Luisa Ribeiro Pinto, Bruna Kelren Freitas Pohlmann   +6 more
doaj   +1 more source

Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2

Annals of Internal Medicine, 2021
Evidence suggests that immunogenicity to mRNA-based SARS-CoV-2 vaccination in immunosuppressed patients may be reduced. This study assessed the response to 2 doses of mRNA-based SARS-CoV-2 vaccine among 133 participants with underlying chronic ...
P. Deepak, Wooseob Kim, Michael A. Paley, Monica M. Yang, A. Carvidi, Emanuel Demissie, Alia A. El-Qunni, Alem Haile, Katherine Huang, Baylee Kinnett, Mariel J. Liebeskind, Zhuoming Liu, L. McMorrow, D. Páez, Niti Pawar, D. Perantie, Rebecca E. Schriefer, Shannon E. Sides, Mahima Thapa, M. Gergely, Suha Abushamma, Sewuese Akuse, Michael K Klebert, Lynne M. Mitchell, D. Nix, J. Graf, K. Taylor, S. Chahin, M. Ciorba, P. Katz, M. Matloubian, Jane A. O’Halloran, R. Presti, Gregory F. Wu, S. Whelan, W. Buchser, L. Gensler, Mary C. Nakamura, A. Ellebedy, A. H. Kim   +39 more
semanticscholar   +1 more source

Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression

Annals of the Rheumatic Diseases, 2021
Objective There is an urgent need to assess the impact of immunosuppressive therapies on the immunogenicity and efficacy of SARS-CoV-2 vaccination. Methods Serological and T-cell ELISpot assays were used to assess the response to first-dose and second ...
M. Prendecki, C. Clarke, Helena Edwards, Stacey McIntyre, P. Mortimer, S. Gleeson, P. Martin, T. Thomson, P. Randell, Anand Shah, A. Singanayagam, L. Lightstone, A. Cox, P. Kelleher, M. Willicombe, S. McAdoo   +15 more
semanticscholar   +1 more source

Preventing kidney transplant failure by screening for antibodies against human leucocyte antigens followed by optimised immunosuppression: OuTSMART RCT

Efficacy and Mechanism Evaluation, 2023
Design Investigator-led, prospective, open-labelled marker-based strategy (hybrid) randomised trial. Background Allografts in 3% of kidney transplant patients fail annually.
Stringer Dominic, Gardner Leanne, Shaw Olivia, Clarke Brendan, Briggs David, Worthington Judith, Buckland Matthew, Hilton Rachel, Picton Michael, Thuraisingham Raj, Borrows Richard, Baker Richard, Tinch-Taylor Rose, Horne Robert, McCrone Paul, Kelly Joanna, Murphy Caroline, Peacock Janet, Dorling Anthony   +18 more
doaj   +1 more source

Evaluation of early and late presentation of patients with ocular mucous membrane pemphigoid to two major tertiary referral hospitals in the United Kingdom [PDF]

, 2011
PURPOSE: Ocular mucous membrane pemphigoid (OcMMP) is a sight-threatening autoimmune disease in which referral to specialists units for further management is a common practise.
AH Ross, BA Rice, BJ Mondino, BJ Mondino, C Radford, CS Foster, CS Foster, CS Yee, D Gladman, E Daniel, E Miserocchi, EH Sacks, G P Williams, GP Williams, H John, J K G Dart, J Risser, J Sheppard, J Tauber, J Tauber, J Tauber, JA Taverna, JE Thorne, JE Thorne, LS Chan, LS Chan, M Ahmed, MJ Canizares, MJ Elder, MJ Elder, MJ Elder, MJ Elder, MP Heffernan, P Nightingale, RJ Barry, RS Rogers III, S Rauz, S Rauz, S Segura, SJ Bowman, VP Saw, VP Saw, W Bernauer, W Bernauer, W Bernauer, W Bernauer   +45 more
core   +2 more sources