Results 51 to 60 of about 4,676,099 (307)

Tacrolimus rescue therapy for renal allograft rejection - Five-year experience [PDF]

, 1997
Over the 5 year period from 7/14/1989 until 5/24/1994, we have attempted graft salvage with tacrolimus conversion in a total of 169 patients (median age 33 years, range 2-75 years) with ongoing rejection on baseline CsA immunosuppression after failure of
Demetris, AJ, Fung, JJ, Gritsch, HA, Jordan, ML, McCauley, J, McMichael, J, Naraghi, R, Randhawa, P, Scantlebury, VP, Shapiro, R, Smith, D, Starzl, TE, Vivas, CA   +12 more
core   +1 more source

A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy

International Journal of Cancer, 2018
YAP1 is one of the most important effectors of the Hippo pathway and has crosstalk with other cancer promoting pathways. YAP1 contributes to cancer development in various ways that include promoting malignant phenotypes, expansion of cancer stem cells ...
M. Shibata, Kendall Ham, M. Hoque
semanticscholar   +1 more source

Weaning of immunosuppression in liver transplant recipients [PDF]

, 1997
Immunosuppression has been sporadically discontinued by noncompliant liver allograft recipients for whom an additional 4 1/2 years of follow-up is provided.
Anand, Anthony J. Demetris, Bridget Flynn, Demetris, Demetris, Fung, George V. Mazariegos, Ignazio R. Marino, John J. Fung, John McMichael, Jorge Reyes, Mazariegos, Molleston, Murase, Pappo, Qian, Ramos, Sanborn, Schlitt, Starzl, Starzl, Starzl, Starzl, Starzl, Thomas E. Starzl, van Hoek, William Irish   +26 more
core   +1 more source

Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression

Science Translational Medicine, 2019
Immune checkpoints can be targeted using exogenous reagents or via genetic modification to enhance the efficacy of adoptive T cell therapy. The development of new cancer immunotherapies including checkpoint blockade and chimeric antigen receptor (CAR) T ...
Sherly Mardiana, B. Solomon, P. Darcy, P. Beavis   +3 more
semanticscholar   +1 more source

Immunogenicity and toxicity of AAV gene therapy

Frontiers in Immunology, 2022
Gene transfer using adeno-associated viral (AAV) vectors has made tremendous progress in the last decade and has achieved cures of debilitating diseases such as hemophilia A and B.
H. Ertl
semanticscholar   +1 more source

Left hand extensor tenosynovitis due to Histoplasma capsulatum complicated by immune reconstitution inflammatory syndrome [PDF]

Journal of Bone and Joint Infection, 2021
We describe a case of left hand extensor tenosynovitis due to histoplasmosis in a patient with dermatomyositis on chronic immunosuppression. Treatment involved surgical debridement and antifungal therapy.
T. Riaz, T. Riaz, M. Collins, M. Enzler, M. Rizzo, A. N. Schuetz, J. S. Lehman, J. S. Lehman, D. Osmon, I. G. Sia   +9 more
doaj   +1 more source

Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series

BMC Infectious Diseases, 2019
BackgroundThe sepsis-induced immunodepression contributes to impaired clinical outcomes of various stress conditions. This syndrome is well documented and characterized by attenuated function of innate and adaptive immune cells.
D. Payen, V. Faivre, J. Miatello, J. Leentjens, C. Brumpt, P. Tissières, C. Dupuis, P. Pickkers, A. Lukaszewicz   +8 more
semanticscholar   +1 more source

Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy

Nature Communications, 2022
Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in hepatocellular carcinoma (HCC) and other cancers, mediated in part by the immunosuppressive tumor microenvironment (TME).
Yuling Xiao, Jiang Chen, Hui Zhou, Xiaodong Zeng, Z. Ruan, Zhangya Pu, Xingya Jiang, A. Matsui, Lingling Zhu, Zohreh Amoozgar, Dean Shuailin Chen, Xiangfei Han, D. Duda, Jinjun Shi   +13 more
semanticscholar   +1 more source

The choice of immunosuppressive therapy depending on the level of anti-HLA antibodies in kidney transplantation

Трансплантология (Москва), 2018
Seeking to develop immunosuppression regimens that would take into account the patient's level of sensitization to the antigens of the main histocompatibility complex, we studied 123 patients after kidney transplantation.
N. V. Borovkova, A. V. Pinchuk, N. V. Shmarina, N. V. Doronina, R. V. Storozhev   +4 more
doaj   +1 more source

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

Frontiers in Immunology, 2018
Clinical and technological advances promoting early hemorrhage control and physiologic resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly decreased in-hospital mortality for many critically ill patient populations.
Hiroyuki Horiguchi, T. Loftus, Russell B. Hawkins, Steven L. Raymond, Julie A. Stortz, Mckenzie Hollen, Brett Weiss, Elizabeth S. Miller, A. Bihorac, S. Larson, A. Mohr, S. Brakenridge, H. Tsujimoto, H. Ueno, F. Moore, L. Moldawer, P. Efron   +16 more
semanticscholar   +1 more source