Results 131 to 140 of about 3,568,234 (327)

Comparison of conventional immunosuppressive drugs versus anti-TNF-α agents in non-infectious non-anterior uveitis

, 2020
Mathilde Leclercq, Vincent Langlois, N. Girszyn, M. Le Besnerais, Y. Benhamou, H. Lévesque, M. Muraine, J. Gueudry   +7 more
openalex   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Impact of immunosuppressive agents on the expression of indoleamine 2,3-dioxygenase, heme oxygenase-1 and interleukin-7 in mesangial cells

, 2015
Guobiao Liang, Guangheng Luo, Dingsu Bao, Anjian Chen, Yongxiang Zhuang, Yanan Guo, Xin Wang, Yuanliang Wang, Zongping Chen, Yiping Lu, YOU-PING LI   +10 more
openalex   +2 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Phase I study of emactuzumab single agent or in combination with paclitaxel in patients with advanced/metastatic solid tumors reveals depletion of immunosuppressive M2-like macrophages [PDF]

, 2019
C. Gomez-Roca, Antoîne Italiano, Christophe Le Tourneau, Philippe A. Cassier, Maud Toulmonde, Sandra P. D’Angelo, Mario Campone, Kristy Weber, Delphine Loirat, Michael A. Cannarile, Anna Maria Jegg, Carola H. Ries, R D Christen, Georgina Meneses‐Lorente, Wolfgang Jacob, Irina Klaman, Chia-Huey Ooi, Carl Watson, Kathrin Wonde, Bernhard Reis, Francesca Michielin, Dominik Rüttinger, Jean‐Pierre Delord, Jean‐Yves Blay   +23 more
openalex   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Immunosuppressive Agents In Uveitis – My Experience

Delhi Journal of Ophthalmology, 2018
Prof. Jyotirmay Biswas
doaj   +1 more source

Validation of Tissue Microarrays for the Study of Immunosuppressive Agent-induced Nephrotoxicity

, 2013
Beom Jin Lim, Ji Hong Kim, Hyeon Joo Jeong   +2 more
openalex   +2 more sources

825. Immunosuppressive Agent Use in Patients with Comorbid HIV and Inflammatory Bowel Disease

, 2021
Travis J Hunt, Patricia Kozuch, Lisa A. Spacek   +2 more
openalex   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source