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Cancer Reports, Volume 8, Issue 10, October 2025.ABSTRACT Background Hairy cell leukemia (HCL) is a rare disorder characterized by splenomegaly, pancytopenia, and proliferation with “hairy” lymphocytes. Treatment is based on purine analogs and anti‐CD20 antibodies, often resulting in significant adverse effects.
M. Garcia Fasanella +4 more
wiley +1 more source
Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells [PDF]
, 2016 Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human
Binz, T. +3 more
core +1 more source
Countering immunotoxin immunogenicity [PDF]
British Journal of Cancer, 2016 The entry of antibody-based drugs into mainstream medicine has provided the oncologist with new therapeutic tools that have begun to transform the treatment of cancer (Scott et al, 2012; Lee et al, 2013). Toxicity profiles and cell killing mechanism(s) exhibited by antibody and small-molecule cytotoxic therapies are largely non-overlapping, thus ...
openaire +2 more sources
Macrophage-Targeted Therapy: CD64-Based Immunotoxins for Treatment of Chronic Inflammatory Diseases
Toxins, 2012 Diseases caused by chronic inflammation (e.g., arthritis, multiple sclerosis and diabetic ulcers) are multicausal, thus making treatment difficult and inefficient. Due to the age-associated nature of most of these disorders and the demographic transition
Theo Thepen +4 more
doaj +1 more source
Mycoflora and Aflatoxin Contamination of Some Foodstuffs [PDF]
, 2013 Analysis was made of the mycoflora and aflatoxin contamination of Rice (Oryza sativa), Beans (Phaseolus vulgaris), Corn (Zea mays), and Groundnut (Arachis hypogaea) sold in four different markets in Sango-Ota, Ogun state, Nigeria.
Olarewaju, S.A., Oranusi, S. U.
core
Immuno-targeting the multifunctional CD38 using nanobody [PDF]
, 2016 published_or_final_versio
Deng, QW +14 more
core +1 more source
Toxins, 2018 SS1P is an anti-mesothelin immunotoxin composed of a targeting antibody fragment genetically fused to a truncated fragment of Pseudomonas exotoxin A. Delayed responses reported in mesothelioma patients receiving SS1P suggest that anti-tumor immunity is ...
Yasmin Leshem +4 more
doaj +1 more source
A case of accidental Ricin poisoning [PDF]
, 2004 A case report of accidental, mild ricin poisoning by ingestion of ten Castor beans by a 70 year old man. The clinical presentation is followed by a discussion about the toxicity of ricin, its use and misuse and the contrast between the toxicity of pure ...
Cachia, Mario J., Despott, Edward
core
VaccinesEffective cancer therapies must address the tumor microenvironment (TME), a complex network of tumor cells and stromal components, including endothelial, immune, and mesenchymal cells. Durable outcomes require targeting both tumor cells and the TME while
Sahar Balkhi +5 more
doaj +1 more source
Antibodies, 2013 Major histocompatibility complex (MHC) class I molecules are key in the immune response against malignant cells by shaping the T-cell repertoire and presenting peptides from endogenous antigens to CD8+ cytotoxic T cells.
Maya Cohen, Yoram Reiter
doaj +1 more source