Results 221 to 230 of about 119,597,839 (255)

In silico design of novel precision vaccine targeting sclerostin epitopes for osteoporosis prevention and treatment. [PDF]

Front Immunol
Luo J, Wu T, Guan B, Li L, Yang Z, Tao H.   +5 more
europepmc   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

In Silico Design, Synthesis, and Antibacterial Evaluation of Allyl Esters of Salicylic and Acetylsalicylic Acid and Their Copolymers. [PDF]

Molecules
Garaev E, Rasulov N, Aliyeva S, Yusifova J.   +3 more
europepmc   +1 more source

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source

In silico design and assessment of a multiepitope and multiantigen potential vaccine candidate against <i>Leishmania donovani</i>. [PDF]

In Silico Pharmacol
Saha S, Laskar S, Gunalan S, Kothandan G, Kumar D.   +4 more
europepmc   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

In Silico Design of gRNA for CRISPR System for Detection of Multidrug Resistant Tuberculosis Using Indian Mycobacterium tuberculosis Genomes: A Computational Study. [PDF]

Cureus
Mittal A, Manna S, Nelson V, Ladha N.
europepmc   +1 more source

Nickel‐Free Perovskite Solar Cells Enabled by Self‐Assembled Monolayers: A Pathway to Efficient and Recyclable Devices

Advanced Energy Materials, EarlyView.
Replacing toxic NiOx with phenyl‐substituted phosphonic‐acid carbazole monolayers (Ph‐5PACz) yields inverted perovskite solar cells that are efficient and recyclable. The nickel‐free interface reaches 25.3% efficiency and enables closed‐loop ITO recovery with near‐98% performance retention, while life‐cycle and techno‐economic analyses confirm lower ...
Yanxue Wang, Roman Kučera, Sinuhé Perea‐Puente, Mykhailo Sytnyk, Andrew Hainer, Zijian Peng, Savannah Bennett, Juan S. Rocha‐Ortiz, Albert These, Hakan U Dag, Qi Fan, Anastasia Barabash, Zhenni Wu, Chaohui Li, Jens Hauch, Olga Kasian, Christoph J. Brabec, Ian Marius Peters   +17 more
wiley   +1 more source

A novel multi-epitope mRNA vaccine against colorectal cancer: in silico design and immune efficacy profiling. [PDF]

Front Immunol
Wang L, Zhou X, Wei Y, Lin J.
europepmc   +1 more source

Integrated in-silico design and in vivo validation of multi-epitope vaccines for norovirus. [PDF]

Virol J
Qiu J, Wei Y, Shu J, Zheng W, Zhang Y, Xie J, Zhang D, Luo X, Sun X, Wang X, Wang S, Wang X, Qiu T.   +12 more
europepmc   +1 more source