The ChIP-seq-defined networks of Bcl-3 gene binding support its required role in skeletal muscle atrophy [PDF]
, 2012 NF-kappaB transcriptional activation is required for skeletal muscle disuse atrophy. We are continuing to study how the activation of NF-kB regulates the genes that encode the protein products that cause atrophy. Using ChIP-sequencing we found that Bcl-3,
Jackman, Robert W. +2 more
core +14 more sources
Computer aided drug design in the development of proteolysis targeting chimeras
Computational and Structural Biotechnology Journal, 2023 Proteolysis targeting chimeras represent a class of drug molecules with a number of attractive properties, most notably a potential to work for targets that, so far, have been in-accessible for conventional small molecule inhibitors.
Tin M. Tunjic +2 more
doaj +1 more source
Food Hydrocolloids for Health, 2023 The protein hydrolysate that contains bioactive peptides of yellowfin tuna (Thunnus albacares) skin collagen with antioxidant activity has been successfully studied by using in silico and in vitro assays. We found that using the in silico assessment, the
Dian Wahyu Wardani +6 more
doaj +1 more source
Characteristics of Potential Protein Nutraceuticals of Plant Origin with Antioxidant Activity
Molecules, 2020 This study used selected plant proteins and the tools available in the BIOPEP-UWM database to profile proteins and release antioxidant nutraceuticals from their primary structures. The frequency of the occurrence of fragments with antioxidant activity in
Iwona Szerszunowicz, Jan Kłobukowski
doaj +1 more source
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII. [PDF]
PLoS ONE, 2017 Coagulation Factor VIII is activated by an ordered limited thrombin proteolysis with different catalytic efficiency at three P1 Arginine residues: Arg759> Arg1708>Arg391, indicating the flanking residues of the latter to be less optimal. This study aimed
Behnaz Pezeshkpoor +7 more
doaj +1 more source
Marine Drugs, 2022 Bioinformatic tools are widely used in predicting potent bioactive peptides from food derived materials. This study was focused on utilizing sea cucumber processing by-products for generating antioxidant and ACE inhibitory peptides by application of a ...
Tharindu R. L. Senadheera +3 more
doaj +1 more source
A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing [PDF]
, 2010 Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the ...
Aaron R. Jex +95 more
core +6 more sources
Characteristics of Biopeptides Released In Silico from Collagens Using Quantitative Parameters
Foods, 2020 The potential of collagens to release biopeptides was evaluated using the BIOPEP-UWM-implemented quantitative criteria including the frequency of the release of fragments with a given activity by selected enzyme(s) (AE), relative frequency of release of ...
Anna Iwaniak +4 more
doaj +1 more source
Green seaweed Ulva lactuca, a potential source of bioactive peptides revealed by in silico analysis
Informatics in Medicine Unlocked, 2022 The green seaweed Ulva lactuca is found in coastal areas. Potential bioactive peptides have a wide range of uses, including antibacterial, antifungal, antiviral, alpha-amylase inhibitory, antiamnestic, ACE inhibitory, immunomodulatory, anticancer ...
Md.Ariful Amin +3 more
doaj +1 more source
In-silico structural and functional characterization of a V. cholerae O395 hypothetical protein containing a PDZ1 and an uncommon protease domain. [PDF]
PLoS ONE, 2013 Vibrio cholerae, the causative agent of epidemic cholera, has been a constant source of concern for decades. It has constantly evolved itself in order to survive the changing environment.
Avirup Dutta +2 more
doaj +1 more source