Results 31 to 40 of about 32,158 (205)

Antioxidant Properties and Prediction of Bioactive Peptides Produced from Flixweed (sophia, Descurainis sophia L.) and Camelina (Camelina sativa (L.) Crantz) Seed Meal: Integrated In Vitro and In Silico Studies

Plants, 2023
Flixweed (sophia) seed meal and camelina, both by-products of oil processing, were employed to generate protein hydrolysates by applying Flavourzyme and Alcalase. This study aimed to integrate in vitro and in silico methods to analyze sophia and camelina
Na Thi Ty Ngo, Tharindu R. L. Senadheera, Fereidoon Shahidi   +2 more
doaj   +1 more source

Antigen processing and presentation in cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy.
Maxwell Y Lee, Cem Sievers, Clint T Allen, Jun W Jeon   +3 more
doaj   +1 more source

Specific inhibitors of urokinase plasminogen activator for treatment of cancers; In silico approach

Translation, 2020
Invasion, metastasis and angiogenesis are fundamental processes in the development of solid cancers. All these depend on the proteolysis where plasminogen activation system (PAS) is the prominent component.
Benjamin Talbot, Jerzy Jankun
doaj   +1 more source

Identification of Antibacterial Peptide Candidates Encrypted in Stress-Related and Metabolic Saccharomyces cerevisiae Proteins

Pharmaceuticals, 2022
The protein-rich nature of Saccharomyces cerevisiae has led this yeast to the spotlight concerning the search for antimicrobial peptides. Herein, a
Maria Fernanda da Silva Santos, Cyntia Silva Freitas, Giovani Carlo Verissimo da Costa, Patricia Ribeiro Pereira, Vania Margaret Flosi Paschoalin   +4 more
doaj   +1 more source

19F NMR spectroscopy monitors ligand binding to recombinantly fluorine-labelled b'x from human protein disulphide isomerase (hPDI) [PDF]

, 2014
We report a protein-observe (19)F NMR-based ligand titration binding study of human PDI b'x with ?-somatostatin that also emphasises the need to optimise recombinant protein fluorination when using 5- or 6-fluoroindole.
Byrne, Crowley, Darby, Denisa Doko, Denisov, Fielding, Freedman, Hatahet, Hatahet, Kirsty L. Richards, Klappa, Koivunen, Mark J. Howard, Michelle L. Rowe, Nakasako, Nguyen, Pirneskoski, Richard A. Williamson, Rose Curtis-Marof, Serve, Tian, Wallis, Wang, Wang, Williamson   +24 more
core   +1 more source

Identification and In Silico Simulation on Inhibitory Platelet-Activating Factor Acetyl Hydrolase Peptides from Dry-Cured Pork Coppa

Foods, 2023
The unique processing technology of dry-cured meat products leads to strong proteolysis, which produces numerous peptides. The purpose of this investigation was the systematic isolation, purification, and identification of potentially cardioprotective ...
Mingming Li, Xin Zhang, Jiapeng Li, Linggao Liu, Qiujin Zhu, Chao Qu, Yunhan Zhang, Shouwei Wang   +7 more
doaj   +1 more source

New compounds from heterocyclic amines scaffold with multitarget inhibitory activity on Aβ aggregation, AChE, and BACE1 in the Alzheimer disease

PLoS ONE, 2022
The preset neurodegenerations in Alzheimer disease (AD) are due to several mechanisms such as amyloidogenic proteolysis, neuroinflammation, mitochondrial dysfunction, neurofibrillary tangles, cholinergic dysfunction, among others.
Iohanan Daniel García Marín, Raúl Horacio Camarillo López, Oscar Aurelio Martínez, Itzia Irene Padilla-Martínez, José Correa-Basurto, Martha Cecilia Rosales-Hernández   +5 more
doaj   +2 more sources

Pyoverdine and proteases affect the response of pseudomonas aeruginosa to gallium in human serum [PDF]

, 2015
Gallium is an iron mimetic which has recently been repurposed as an antibacterial agent due to its capability to disrupt bacterial iron metabolism. In this study, the antibacterial activity of gallium nitrate [Ga(NO3)3] was investigated in complement ...
Bonchi, Carlo, Frangipani, Emanuela, Imperi, Francesco, Visca, Paolo   +3 more
core   +1 more source

CD4+ Th immunogenicity of the Ascaris spp. secreted products [PDF]

, 2020
Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines.
Bertazzon, Miriam, Ebner, Friederike, Freund, Christian, Hartmann, Susanne, Midha, Ankur, Morrison, Eliot, Álvaro-Benito, Miguel   +6 more
core   +1 more source

A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. [PDF]

, 2012
BackgroundEukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex ...
DaSilva, Lance F, Duncker, Bernard P, Gidvani, Rohan D, Ingalls, Brian P, Li, Grace, McConkey, Brendan J, Sudmant, Peter   +6 more
core   +3 more sources