Results 131 to 140 of about 120,404,711 (181)
Smart materials and additive manufacturing for functional reconstruction in general surgery: responsive hydrogels, bioinks, patient-specific scaffolds, and translational validation. [PDF]
Front Bioeng BiotechnolLou Y, He R, Liu X, Wang H.
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Single bi-functional flexible sensor device for simultaneous pH and oxygen monitoring during pre-transplant normothermic perfusion. [PDF]
Microsyst NanoengSett A +8 more
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Chronobiology International, 2012 The circadian timing system (CTS) governs the 24-h rhythm of the organism and, hence, also main pathways responsible for drug pharmacokinetics. P-glycoprotein (P-gp) is a drug transporter that plays a pivotal role in drug absorption, distribution, and elimination, and temporal changes in its activity may affect input, output, activity, and toxicity ...
Alper Okyar, Abeer Hanafy, Björn Lemmer
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Biopharmaceutics and Drug Disposition, 2010 The present study explored the feasibility of a differential setup for the in situ perfusion technique with mesenteric cannulation in rats to assess drug interactions at the level of intestinal absorption.
Joachim Brouwers +2 more
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In Situ Perfusion in Rodents to Explore Intestinal Drug Absorption: Challenges and Opportunities
International Journal of Pharmaceutics, 2015 The in situ intestinal perfusion technique in rodents is a very important absorption model, not only because of its predictive value, but it is also very suitable to unravel the mechanisms underlying intestinal drug absorption. This literature overview covers a number of specific applications for which the in situ intestinal perfusion set-up can be ...
Joachim Brouwers +2 more
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Intestinal Absorption by Perfusion in Situ
Journal of Applied Physiology, 1957An apparatus and technique for the perfusion of a specific cannulated segment of small intestine of the rat, in situ, have been described. By the removal and analysis of perfusate samples from the system, continuous intestinal absorption curves have been established from a single animal in the steady state.
F A, JACOBS, M, LUPER
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Optimal Perfusion Rate Determined for in Situ Intestinal Absorption Studies in Rats
Journal of Pharmaceutical Sciences, 1981Iopanoic acid was used as a model compound to study the effect of the intestinal perfusion rate on the mean absorption clearance. Absorption of iopanoic acid followed first-order kinetics, with a first-order absorption rate constant (ka) linearly dependent on the dry intestinal weight. An absorption clearance--time plot revealed three phases.
P M, Savina +3 more
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International Journal of Pharmaceutics, 2011 In rats we examined the effects of some common excipients on the intestinal absorption of ganciclovir (GCV), a BCS-III drug and substrate of P-gp, by assessing its in vitro transfer from mucosa to serosa and in situ transepithelial permeation. In vitro,
Luqin Si, Ming Li, Abdullah K Rabba
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Intestinal Permeability of Forskolin byIn SituSingle Pass Perfusion in Rats
Planta Medica, 2012The intestinal permeability of forskolin was investigated using a single pass intestinal perfusion (SPIP) technique in rats. SPIP was performed in different intestinal segments (duodenum, jejunum, ileum, and colon) with three concentrations of forskolin (11.90, 29.75, and 59.90 µg/mL).
Zhen-Jun, Liu +5 more
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