Results 141 to 150 of about 120,404,711 (181)

The Preparation of Garcinia Glycosides Solid Dispersion and Intestinal Absorption by Rat in Situ Single Pass Intestinal Perfusion

Journal of Pharmaceutical and Biopharmaceutical Research, 2019
Garcinia Glycosides is a candidate drug obtained by structural modification of Gambogic Acid (GA), which was acquired through High Throughput Screening(HTS). As Garcinia Glycosides is an effective but insoluble anti-tumor drug, the aim of this study was to obtain a solid dispersion form Garcinia Glycosides by using solvent-melt method so that improve ...
Hong-Sheng Liu, Yinghui Chen
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

The assessment of absorption of periplocin in situ via intestinal perfusion of rats by HPLC

Biomedical Chromatography, 2007
AbstractPeriplocin is an important compound of Cortex Periplocae, which shows poor absorption when administered orally. The effective intestinal permeability of periplocin was investigated using single‐pass intestinal perfusion technique in male Wistar rats. SPIP was performed in rat jejunum.
Yue-Sheng, Xie, Xiao-Liang, Ren, Gui-Xiang, Pan, Xiu-Mei, Gao, Chang-Xiao, Liu   +4 more
openaire   +2 more sources

Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation.

Drug Metabolism and Disposition, 1986
The in situ perfused rat small intestine preparation was used to examine the extents of segmental absorption and metabolism of acetaminophen (A). Additionally, the preparation was employed to investigate any intestinal excretion of A and its conjugates from the circulation to the intestinal lumen.
K S, Pang, V, Yuen, S, Fayz, J M, te Koppele, G J, Mulder   +4 more
openaire   +2 more sources

Disposition of (-)carbovir in the in situ perfused rat liver and intestinal vasculature preparations.

Drug Metabolism and Disposition, 1993
Carbovir (CBV), a carbocyclic nucleoside analog, is a potent and selective inhibitor of human immunodeficiency virus in human T-cells at noncytotoxic concentrations. Previous pharmacokinetic studies of (-)CBV in the rat showed nonlinearity in both the renal and nonrenal clearances and an oral bioavailability of 20%.
I, Soria, C L, Zimmerman
openaire   +2 more sources

In Situ Intestinal Perfusion in Rodents: Future Perspectives for Application on Absorption Studies and Classification of Drugs

Mini-Reviews in Medicinal Chemistry, 2017
In 1995, the Biopharmaceutics Classification System (BCS) was proposed by Amidon and colleagues as a tool that considers two important parameters regarding drugs: solubility and permeability. Since then, several methods for solubility and permeability studies have been developed for drug delivery and absorption prediction. In recent years, permeability
Thaisa Marinho, Dezani, Andre Bersani, Dezani, Monica Maria Coquemala, de Silva, Cristina Helena, Dos Reis Serra   +3 more
openaire   +2 more sources

[Intestinal absorption of daphnetin by rats single pass perfusion in situ].

Yao xue xue bao = Acta pharmaceutica Sinica, 2012
This study investigated the effects of concentration, intestinal section, pH and P-gp on the absorption of daphnetin. The absorptions of three concentrations (10, 20, 40 microg x mL(-1)) of daphnetin in different intestinal segments were studied with phenol red as the marker by in situ rats single pass perfusion model. The results showed that daphnetin
Qiu, Du, Liu-Qing, Di, Jin-Jun, Shan, Tao-Shi, Liu, Xin-Zhuang, Zhang   +4 more
openaire   +1 more source

[Intestinal absorption of berberine alone and in combinations by rats single pass intestinal perfusion in situ].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
The aim of the study is to investigate the effects of concentration, intestinal segments, pH, inhibitors of proteins (P-gp), Na(+)-dependent glucose transporter (SGLT1) on the intestinal absorption of berberine, and to compare intestinal absorption of berberine in combinations. With phenol red as the indicator, in situ single pass intestinal perfusion (
Yan, Zhang, Hua-Xu, Zhu, Li-Wei, Guo
openaire   +1 more source

A Short Time Rat Model of Mucosal Inflammation by in Situ Perfusion of an Intestinal Segment

Gastroenterology, 2011
Background: The extent to which numerous strains of genetically engineered mice, including mice lacking toll-like receptor 5 (T5KO), display colitis that is environment-dependent with the gut microbiota underlying much of the variance in phenotype.
Anne Breitrueck, Gisela Sparmann, Joerg Emmrich   +2 more
openaire   +1 more source

The Intestinal Absorption of a Prodrug of the mGlu2/3 Receptor Agonist LY354740 is Mediated by PEPT1: In Situ Rat Intestinal Perfusion Studies

Journal of Pharmaceutical Sciences, 2010
LY354740 is a potent mGlu2/3 agonist with a limited oral bioavailability. Its alanyl prodrug, LY544344, showed high affinity to the intestinal peptide transporter PEPT1, and improved the oral bioavailability of LY354740 in various animal models. The aim of the present study was to investigate the mechanism of in vivo absorption of the dipeptidic ...
André H, Eriksson, Manthena V S, Varma, Everett J, Perkins, Cheryl L, Zimmerman   +3 more
openaire   +2 more sources

Intestinal Absorption of γ-Tocotrienol Is Mediated by Niemann-Pick C1-Like 1: In Situ Rat Intestinal Perfusion Studies

Drug Metabolism and Disposition, 2010
gamma-Tocotrienol (gamma-T3) is a member of the vitamin E family that displays potent anticancer activity and other therapeutic benefits. The objective of this study was to evaluate gamma-T3 intestinal uptake and metabolism using the in situ rat intestinal perfusion model. Isolated segments of rat jejunum and ileum were perfused with gamma-T3 solution,
Bilal, Abuasal, Paul W, Sylvester, Amal, Kaddoumi   +2 more
openaire   +2 more sources