Results 31 to 40 of about 2,554,686 (233)

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

Pharmaceutics, 2022
The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the pKa and the pH-solubility profile were
Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Alex Avdeef, Miguel-Ángel Cabrera-Pérez   +7 more
doaj   +1 more source

Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies

Pharmaceutics, 2022
The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in this study.
Marlies Braeckmans, Patrick Augustijns, Raf Mols, Cécile Servais, Joachim Brouwers   +4 more
doaj   +1 more source

Synthesis and Evaluation of PEG-PR for Water Flux Correction in an In Situ Rat Perfusion Model

Molecules, 2020
Phenol red (PR) is a widely used marker for water flux correction in studies of in situ perfusion, in which intestinal absorption usually leads to the underestimation of results. In this paper, we propose a novel marker polyethylene glycol (PEG)-PR (i.e.,
Guo Chen, Xingqi Min, Qunqun Zhang, Zhiqiang Zhang, Meiqiang Wen, Jun Yang, Meijuan Zou, Wei Sun, Gang Cheng   +8 more
doaj   +1 more source

Etretinate absorption in the in situ perfused intestinal lumen: Preliminary studies in the rat [PDF]

Biopharmaceutics & Drug Disposition, 1991
AbstractThe absorption characteristics of etretinate were examined in the Sprague‐Dawley rat with the use of the in situ intestinal lumen perfusion model. Intestinal segments of 15–50cm were cannulated and perfused with etretinate solutions of 178–1405 μgml−1 in a single‐pass manner at flow rates of 0·15–0·96 ml min−1.
Cheryl L. Zimmerman, Kenneth E. Johnson
openaire   +3 more sources

Bioavailability and biotransformation of benzo(a)pyrene in an isolated perfused In situ catfish intestinal preparation. [PDF]

Environmental Health Perspectives, 1998
In the aquatic environment, diet is an important route of exposure for the common contaminant and procarcinogen benzo(a)pyrene (BaP). Dietary organisms vary in their BaP content and in contaminated areas often contain other xenobiotics including cytochrome P4501A inducers.
Margaret O. James, Changaram S. Venugopalan, Zeen Tong, Kevin M. Kleinow   +3 more
openaire   +3 more sources

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William, Dufès, Christine, Gaillard, Afsaneh, Gaillard, Frédéric, Muller, Jean-Marc, Olivier, Jean-Christophe   +5 more
core   +1 more source

Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat

Molecules, 2014
Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the
Yan Huo, Yuxing Huang, Xiangmei Hou, Lifeng Han, Lei Wang, Erwei Liu, Xiumei Gao   +6 more
doaj   +1 more source

Effect of ischemia on the canine large bowel: A comparison with the small intestine [PDF]

, 1996
Mucosal injury caused by ischemia and reperfusion has been well documented with the small intestine, but little is known about the colon. In the present study, the effect of warm and cold ischemia on the canine colon was studied and compared to that on ...
Ikoma, A, Nakamura, K, Starzl, TE, Takeyoshi, I, Todo, S, Zhang, S, Zhu, Y   +6 more
core   +1 more source

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken [PDF]

, 2018
Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear ...
A Pedretti, AM Haritova, C Issa, CH Nightingale, D Carvalho, D Osguthorpe, D Sadowski, E Abu-Basha, E Chieli, H Elsheikh, J Dupuy, J Formica, J Sugatani, J Yang, JS Choi, JS Choi, K Lohner, K Yamaoka, KJ Livak, L Gibellini, L Li, LR Fortunato, M Goliomytis, M Guo, M Guo, M Nair, MD Hanwell, MM Pulido, MP Nair, MR Durk, O Trott, P Zakeri-Milani, P Zakeri-Milani, PV Balimane, R Walker, S Borska, S Kim, S Wang, SL Hsiu, T Guo, T Guo, TT Cushnie, V Madgula, W Li, X Liu, Y Hee Choi, YJ Chae, YQ Shan, Z Chen   +48 more
core   +2 more sources

FROG INTESTINAL PERFUSION TO EVALUATE DRUG PERMEABILITY: APPLICATION TO P-gp AND CYP3A4 SUBSTRATES

Frontiers in Pharmacology, 2015
To evaluate the reliability of using in situ frog intestinal perfusion technique for permeability assessment of carrier transported drugs which are also substrates for CYP enzymes.
Neelima eYerasi, krishna edevarakonda, Himabindu evurimindi   +2 more
doaj   +1 more source