Results 31 to 40 of about 26,404 (336)

FROG INTESTINAL PERFUSION TO EVALUATE DRUG PERMEABILITY: APPLICATION TO P-gp AND CYP3A4 SUBSTRATES

Frontiers in Pharmacology, 2015
To evaluate the reliability of using in situ frog intestinal perfusion technique for permeability assessment of carrier transported drugs which are also substrates for CYP enzymes.
Neelima eYerasi, krishna edevarakonda, Himabindu evurimindi   +2 more
doaj   +1 more source

Preparation of Puerarin Chitosan Oral Nanoparticles by Ionic Gelation Method and Its Related Kinetics

Pharmaceutics, 2020
In this paper, as an active ingredient, puerarin chitosan nanoparticles (Pur-CS/TPP-NPs) are prepared by an ionic gelation method. The chitosan (CS) concentration, pH of the CS solution, sodium tripolyphosphate (TPP) concentration, stirring speed ...
Jie Yan, Zhi-Yu Guan, Wei-Feng Zhu, Ling-Yun Zhong, Zhuo-Qi Qiu, Peng-Fei Yue, Wen-Ting Wu, Jing Liu, Xiao Huang   +8 more
doaj   +1 more source

Reduction in jejunal fluid absorption in vivo through distension and cholinergic stimulation not attributable to enterocyte secretion [PDF]

, 2018
Jejunal fluid absorption in vivo was reduced by distension and by hydrostatic pressure and further declined on adding E. coli STa enterotoxin but no net fluid secretion was detected.
Graham, V., Kenward, H., Lucas, M., McColl, S., McNaughton, E., Sabir, S., Tainsh, P., Turkington, C., Watson, P.   +8 more
core   +1 more source

Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption

Frontiers in Pharmacology, 2021
Background: Sorafenib (SOR) is an oral, potent, selective, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used as the first-line therapy for advanced hepatocellular carcinoma (HCC).
Jingyao Wei, Jingyao Wei, Ruijuan Liu, Ruijuan Liu, Jiali Zhang, Jiali Zhang, Shuaibing Liu, Shuaibing Liu, Dan Yan, Dan Yan, Xueqian Wen, Xueqian Wen, Xin Tian, Xin Tian   +13 more
doaj   +1 more source

Intestinal absorption of the wheat allergen gliadin in rats

Allergology International, 2019
Background: Aspirin enhances food allergy symptoms by increasing absorption of ingested allergens. The objective of this study is to elucidate the role of aspirin in facilitating intestinal absorption of the wheat allergen, gliadin, in rats.
Tomoharu Yokooji, Takahiro Fukushima, Koh Hamura, Naoki Ninomiya, Ryo Ohashi, Takanori Taogoshi, Hiroaki Matsuo   +6 more
doaj   +1 more source

Modeling of breath methane concentration profiles during exercise on an ergometer [PDF]

, 2016
We develop a simple three compartment model based on mass balance equations which quantitatively describes the dynamics of breath methane concentration profiles during exercise on an ergometer.
Jandacka, Martin, King, Julian, Mochalski, Pawel, Mohacsi, Arpad, Ruzsanyi, Vera, Szabo, Anna, Szabo, Gabor, Teschl, Gerald, Teschl, Susanne, Unterkofler, Karl   +9 more
core   +2 more sources

The Effects of Cetirizine on P-glycoprotein Expression and Function In vitro and In situ [PDF]

Advanced Pharmaceutical Bulletin, 2016
Purpose: P-glycoprotein (P-gp) plays a major role in oral absorption of drugs. Induction or inhibition of P-gp by drugs contributes to variability of its transport activity and often results in clinically relevant drug-drug interactions.
Mehran Mesgari Abbasi, Hadi Valizadeh, Hamed Hamishekar, Leila Mohammadnejad, Parvin Zakeri-Milani   +4 more
doaj   +1 more source

An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat [PDF]

, 2015
In the absence of an ability to absorb fluid by cellular uptake mechanisms, fluid movement in vivo from the perfused rat intestine is absorptive when the diastolic blood pressure is normal or very low but is secretory when blood pressure falls below ...
Lucas, Michael, Morrison, James
core   +1 more source

Synthetic Vasopressin and Oxytocin Analogs and Their Potential Use in Hemorrhagic, Traumatic and Septic Shock: A Personal Perspective [PDF]

, 2017
As one of us has stated many years ago, “shock is a significant and sustained loss of effective circulating blood volume. It will eventuate in hypoperfusion of critical peripheral tissues, thus leading to a deficit in transcapillary exchange function in ...
Altura BM, Carella A, Gebrewold A, Altura BT   +3 more
core   +1 more source

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken [PDF]

, 2018
Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear ...
A Pedretti, AM Haritova, C Issa, CH Nightingale, D Carvalho, D Osguthorpe, D Sadowski, E Abu-Basha, E Chieli, H Elsheikh, J Dupuy, J Formica, J Sugatani, J Yang, JS Choi, JS Choi, K Lohner, K Yamaoka, KJ Livak, L Gibellini, L Li, LR Fortunato, M Goliomytis, M Guo, M Guo, M Nair, MD Hanwell, MM Pulido, MP Nair, MR Durk, O Trott, P Zakeri-Milani, P Zakeri-Milani, PV Balimane, R Walker, S Borska, S Kim, S Wang, SL Hsiu, T Guo, T Guo, TT Cushnie, V Madgula, W Li, X Liu, Y Hee Choi, YJ Chae, YQ Shan, Z Chen   +48 more
core   +3 more sources