In vitro–in vivo correlation ivivc

Results 11 to 20 of about 1,092 (147)

Candesartan Cilexetil In Vitro–In Vivo Correlation: Predictive Dissolution as a Development Tool [PDF]

Pharmaceutics, 2020
The main objective of this investigation was to develop an in vitro–in vivo correlation (IVIVC) for immediate release candesartan cilexetil formulations by designing an in vitro dissolution test to be used as development tool.
Andrés Figueroa-Campos +7 more
doaj +3 more sources

Development of Level A In Vitro–Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation

Pharmaceutics, 2020
This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro−in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution.
Dong-Seok Lee +4 more
doaj +2 more sources

In Vitro – In Vivo Correlation of Pentoxifylline: A Comprehensive Kinetic Analysis

Studia Universitatis Babes-Bolyai Chemia
This study presents an analysis of In Vitro-In Vivo Correlation (IVIVC) for pentoxifylline modified-release tablets, with a focus on deriving robust predictive models.
Maria CODREANU +5 more
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In Vitro–In Vivo Correlations Based on In Vitro Dissolution of Parent Drug Diltiazem and Pharmacokinetics of Its Metabolite

Pharmaceutics, 2019
In this study a novel type of in vitro−in vivo correlation (IVIVC) is proposed: The correlation of the in vitro parent drug dissolution data with the in vivo pharmacokinetic data of drug’s metabolite after the oral administration of the ...
Constantin Mircioiu +4 more
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Evaluating the bioequivalence of two pitavastatin calcium formulations based on IVIVC modeling and clinical study

Clinical and Translational Science, 2023
In vitro‐in vivo correlation (IVIVC) allows prediction of the in vivo performance of a pharmaceutical product based on its in vitro drug release profiles and can be used to reduce the number of bioequivalence (BE) studies during product development, and ...
Jiaying Wang +7 more
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Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks [PDF]

Drug Design, Development and Therapy, 2013
Aleksander Mendyk,1 Pawel Tuszynski,1 Sebastian Polak,2 Renata Jachowicz1 1Department of Pharmaceutical Technology and Biopharmaceutics, 2Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland ...
Mendyk A, Tuszyński PK, Polak S, Jachowicz R +3 more
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A convolution‐based in vitro‐in vivo correlation model for methylphenidate hydrochloride delayed‐release and extended‐release capsule

CPT: Pharmacometrics & Systems Pharmacology
Delayed‐release and extended‐release methylphenidate hydrochloride (JORNAY PM®) is a novel capsule formulation of methylphenidate hydrochloride, used to treat attention deficit hyperactivity disorder in patients 6 years and older.
Pawan Kumar Gupta +3 more
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Pharmacokinetic aspects and in vitro–in vivo correlation potential for lipid-based formulations

Acta Pharmaceutica Sinica B, 2014
Lipid-based formulations have been an attractive choice among novel drug delivery systems for enhancing the solubility and bioavailability of poorly soluble drugs due to their ability to keep the drug in solubilized state in the gastrointestinal tract ...
Sivacharan Kollipara, Rajesh Kumar Gandhi +1 more
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In Vitro–In Vivo Correlation of Tianeptine Sodium Sustained-Release Dual-Layer Tablets

Molecules, 2022
Tianeptine tablets are currently marketed to be designed for immediate-release tablets. The tianeptine has a short half-life, making it difficult to design for sustained-release tablets and achieve bioequivalence with the tianeptine immediate-release ...
Ye-Ji Lee, Joo-Eun Kim
doaj +2 more sources

Development of novel risperidone implants using blends of polycaprolactones and in vitro in vivo correlation studies

Journal of Advanced Pharmaceutical Technology & Research, 2014
The objective of this study was to develop a novel implant containing risperidone intended for long-term treatment in Schizophrenia utilizing in vitro in vivo correlation (IVIVC) studies.
Aerrolla Navitha +3 more
doaj +2 more sources

ivivc
in vitro–in vivo correlation
pharmacokinetics

bioequivalence
dissolution
sustained release

pharmacology
therapeutics
in vitro dissolution