Results 21 to 30 of about 1,092 (147)

In Vitro Evaluation of Poly(D,L-lactide-co-glycolide) In Situ Gels and Pharmacokinetics Following Subcutaneous Injection in Rats for Model Drugs [PDF]

Pharmaceutics
Background/Objectives. This research supports the development of long-acting injectables (LAIs) via in situ gel (ISG) technology by illustrating the influence of drug properties and formulation variables on in vitro drug release (Part 1), and providing ...
Sandy Van Hemelryck, Charlotte Vercammen, Eline Seldeslachts, Koen Wuyts, Ils Pijpers, René Holm, Erik Mannaert, Peter Langguth   +7 more
doaj   +2 more sources

In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability

Journal of Pharmaceutical Analysis, 2015
Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk.
Baishakhi Dey, Prakash Katakam, Fathi H. Assaleh, Babu Rao Chandu, Shanta Kumari Adiki, Analava Mitra   +5 more
doaj   +2 more sources

Establishment of Dissolution Test Method for Multi-Components in Traditional Chinese Medicine Preparations Based on In Vitro–In Vivo Correlation [PDF]

Pharmaceuticals
In this study, a multi-component integrated dissolution evaluation system of Yuanhu Zhitong tablets (YZTs) was established based on in vitro and in vivo correlation (IVIVC).
Pengcheng Guo, Qizheng Wang, Xiaoqiang Xiang, Yufeng Zhang, Yue Pan, Zhong Zuo, Jianxin Wang   +6 more
doaj   +2 more sources

Physiologically-Based Pharmacokinetic Modeling and In Vitro–In Vivo Correlation of TV-46000 (Risperidone LAI): Prediction from Dog to Human [PDF]

Pharmaceutics
The interest in the development and therapeutic application of long-acting injectable products for chronic or long-term treatments has experienced exponential growth in recent decades.
David Bibi, Raphael Bilgraer, Lilach Steiner, Hussein Hallak   +3 more
doaj   +2 more sources

In vitro-in vivo correlation (IVIVC) development for long-acting injectable drug products based on poly(lactide-co-glycolide). [PDF]

J Control Release
Wang Y, Otte A, Park H, Park K.
europepmc   +2 more sources

Surfactants Significantly Improved the Oral Bioavailability of Curcumin Amorphous Solid Dispersions and Its Underlying Mechanism [PDF]

Pharmaceutics
Background/Objectives: Surfactants are commonly used in amorphous solid dispersions (ASDs) to improve drug dissolution. A mechanistic understanding of their impact on in vitro dissolution and in vivo pharmacokinetics is essential for rational ASD design ...
Jinhua Yuan, Siyi Mao, Xiuzhen Ma, Xiaoling Liu, Yuejie Chen   +4 more
doaj   +2 more sources

Development of a Predictive Flow Through Cell Dissolution Method for Carbamazepine Modified-Release Tablets. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Predictive in vitro dissolution methods are crucial for anticipating in vivo drug performance, particularly for poorly soluble drugs like carbamazepine. In vitro‐in vivo correlations (IVIVC) link dissolution characteristics to pharmacokinetics, facilitating bioequivalence studies and reducing reliance on clinical trials.
Carvajal Barbosa L, Echeverry SM, Aragón DM.   +2 more
europepmc   +2 more sources

In vitro-in vivo correlation (IVIVC) of different parameters of dosage form

Journal of Contemporary Pharmacy, 2021
Researchers can achieve rapid drug production by discovering a mathematical link between bioavailability and dissolution testing that leads to the principle of in vitro - in vivo correlation (IVIVC). IVIVC is a mathematical model which from its in vitro
Shazia Ashraf, Azka Ali, Uzma Noreen, Iqra Abdullah Jan   +3 more
doaj   +1 more source

Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution

Pharmaceutics, 2023
Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness.
Magdalena Markowicz-Piasecka, Marcin Kubisiak, Katarzyna Asendrych-Wicik, Michał Kołodziejczyk, Joanna Grzelińska, Małgorzata Fabijańska, Tomasz Pietrzak   +6 more
doaj   +1 more source

In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging

Acta Pharmaceutica Sinica B, 2021
In vitro‒in vivo correlation (IVIVC) of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients. Nevertheless, in vivo dissolution profiles have never been accurately portrayed. The
Yinqian Yang, Yongjiu Lv, Chengying Shen, Tingting Shi, Haisheng He, Jianping Qi, Xiaochun Dong, Weili Zhao, Yi Lu, Wei Wu   +9 more
doaj   +1 more source