Results 51 to 60 of about 1,092 (147)

Toward Integrative Predictive Toxicology: Advanced Methods for Drug Toxicity and Safety Prediction

WIREs Computational Molecular Science, Volume 16, Issue 1, January/February 2026.
This figure summarizes the different methods in integrative predictive toxicology reviewed in this work, ranging from exploration of molecular mechanisms to in silico pharmacokinetic modeling and construction of adverse outcome pathway (AOP) networks based on key events (KEs) and key event relationships (KERs). Further integration with multi‐omics data
Eleonora Gianquinto, Matteo Bersani, Lucrezia Armando, Lara Davani, Clara Cena, Angela De Simone, Francesca Spyrakis   +6 more
wiley   +1 more source

Time scaling for in vitro-in vivo correlation: the inverse release function (IRF) approach

, 2018
International audienceIn vitro-in vivo correlations (IVIVC) are methods used to create a link between biopharmaceutical properties such as dissolution and physiological response such as plasma concentration. Level A IVIVC defines 1:1 relationship between
Cardot, Jean-Michel, Muniz, Paula, Lukas, John C   +2 more
core   +1 more source

Green‐Synthesized Titanium Dioxide Nanoparticles: Current Status, Technological Advances, and Sustainable Applications

Journal of Nanotechnology, Volume 2026, Issue 1, 2026.
Rapid industrialization and urbanization have intensified environmental pollution, including persistent organic contaminants and toxic metals that threaten ecosystems and human health. Green‐synthesized titanium dioxide (TiO2) nanoparticles (NPs) are gaining attention for their lower‐hazard reagents, reduced energy inputs, and competitive performance ...
Tusha Yadav, Prabhjot Singh Jassal, Mahek Saini, Sudhakar Kancharla, Prachetha Kolli, Gowtham Mandadapu, Manoj Kumar Jena, Rajaram Rajamohan   +7 more
wiley   +1 more source

Hepatic intracellular free drug concentration and unbound partition coefficient: development and validation of an in vitro methodology to predict in vivo liver drug exposure

, 2023
reservedThe Free drug hypothesis states that only the unbound drug molecules are able, in the site of action, to interact with the target and exert the pharmacodynamic effect.
FONTANA, NICCOLÒ
core  

Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations

Applied Sciences, 2020
The increasing emergence of drug-resistant tuberculosis requires new effective and safe drug regimens. However, drug discovery and development are challenging, lengthy and costly.
Rob C. van Wijk, Rami Ayoun Alsoud, Hans Lennernäs, Ulrika S. H. Simonsson   +3 more
doaj   +1 more source

10122 Development of an In Vitro in Vivo Correlation of Itraconazole Spray-Dried Dispersion Tablets

Journal of Clinical and Translational Science, 2021
IMPACT: As the number of poorly water-soluble drugs in development increases, our research will expand on the science behind improving drug solubility and absorption and ensuring that promising poorly-water solubility drugs do not fail drug development ...
Ana Luisa Coutinho, Asmita Adhikari, James Polli   +2 more
doaj   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1329-1339, December 2025.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

In vitro–in vivo correlation from lactide-co-glycolide polymeric dosage forms

, 2014
The objective of this study was to compare the in vitro behavior of four long-acting subcutaneous ris- peridone formulations with in vivo performance, with the intent of establishing an IVIVC. Two copolymers of PLGA (50:50 and 75:25) were used to prepare
Patrick P. DeLuca, Jabar Faraj, Susan D'Souza, Susan D’Souza, Jabar A. Faraj, Stefano Giovagnoli, GIOVAGNOLI, Stefano   +6 more
core   +1 more source

Development of a New Type of Prolonged Release Hydrocodone Formulation Based on Egalet® ADPREM Technology Using In Vivo–In Vitro Correlation

Pharmaceutics, 2011
A novel abuse deterrent, prolonged release tablet formulation of Hydrocodone for once-daily dosing has been developed, based on the novel proprietary Egalet® ADPREM technology.
Jean-Michel Cardot, Christine Gunnergaard, Pernille H. Hemmingsen, Anne-Mette Haahr   +3 more
doaj   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1499-1511, December 2025.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source