Results 71 to 80 of about 1,092 (147)

Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines

Nano TransMed
Nanotechnology enables the achievement of the desired outcomes of nano-formulations, and the mode of drug delivery from the nanoparticles can significantly impact the efficacy of the embedded drug. This article reviews the various types of nanoparticles,
Ugochi E. Ewii, Anthony A. Attama, Emmanuel O. Olorunsola, Adaeze Linda Onugwu, Fortune Uchechukwu Nwakpa, Chioma Anyiam, Chinonye Chijioke, Toochukwu Ogbulie   +7 more
doaj   +1 more source

Development of in vitro-in vivo correlation for nimesulide loaded ethylcellulose microparticles [PDF]

, 2010
A predictive in vitro-invivo correlation (IVIVC) can empower in vitro dissolution as a surrogate for in vivo bioavailability / bioequivalence. IVIVCs can decrease regulatory burden by decreasing the number of biostudies required in support of a drug ...
Khan, Shujaat A., Madni, Asadullah, Shoaib, Harris M., Aamir, Muhammad N., Kousar, Rozina, Rasool, Fatima, Murtaza, Ghulam, Ahmad, Mahmood   +7 more
core  

A New Rapidly Absorbed Paracetamol Tablet Containing Sodium Bicarbonate. II. Dissolution Studies and In Vitro/In Vivo Correlation

, 2002
The objective of this study was to compare the in vitro dissolution profile of a new rapidly absorbed paracetamol tablet containing sodium bicarbonate (PS) with that of a conventional paracetamol tablet (P), and to relate these by deconvolution and ...
Conway, Barbara R, Grattan, Tim J., Shiran, M.R., Rostami-Hodjegan, A., Irwin, William J., Shaw, Lance R., Tucker, G.T.   +6 more
core   +1 more source

IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening

Pharmaceutics, 2019
Since most preclinical drug permeability assays across the blood-brain barrier (BBB) are still evaluated in rodents, we compared an in vitro mouse primary endothelial cell model to the mouse b.End3 and the acellular parallel artificial membrane ...
Ina Puscas, Florian Bernard-Patrzynski, Martin Jutras, Marc-André Lécuyer, Lyne Bourbonnière, Alexandre Prat, Grégoire Leclair, V. Gaëlle Roullin   +7 more
doaj   +1 more source

In vitro–in vivo and pharmacokinetic evaluation of solid lipid nanoparticles of furosemide using Gastroplus™

, 2017
In this work, we conducted pharmacokinetic studies and established the in vitro and in vivo correlation (IVIVC) of furosemide (FRS) loaded solid lipid nanoparticles (FSLN).
Jayachandran Venkatesan, Hasan Ali, Se-Kwon Kim, Sandeep Kumar Singh, Priya Ranjan Prasad Verma, Sunil Kumar Dubey, Youngwan Seo   +6 more
core   +1 more source

Establishment of In Vitro Dissolution Based on Similarity with In Vivo Dissolution: A Case Study on Aripiprazole

, 2023
In vitro dissolution that predicts the in vivo performance of solid preparations is extremely important in formulation optimization. Fraction absorbed (Fa) has been used to screen in vitro dissolution protocols based on the idea of in vitro–in vivo ...
Yinqian Yang, Jianping Qi, Fulong Man (14079540), Wei Wu, Wei Wu (27708), Haisheng He, Jianping Qi (3242970), Yinqian Yang (15215146), Fulong Man, Haisheng He (3242973), Yi Lu (6211), Yi Lu   +11 more
core   +1 more source

Can semipermeable membranes coating materials influence in vivo performance for paliperidone tri-layer ascending release osmotic pump tablet: In vitro evaluation and in vivo pharmacokinetics study

Asian Journal of Pharmaceutical Sciences, 2015
One purpose of this study was to develop a paliperidone (PAL) tri-layer ascending release push–pull osmotic pump (TA-PPOP) tablet which could meet the needs of clinical applications.
Guangjing Li, Yongjun Wang, Hongming Chen, Donglei Leng, Panqin Ma, Yanjie Dong, Lifang Gao, Zhonggui He   +7 more
doaj   +1 more source

An overview of the alarming impediments encountered while establishing an apposite IVIVC of nanomedicines necessitated its regulatory approval

OpenNano
For the past three decades, the principle of nanotechnology has been widely employed to develop pharmaceuticals and bio-pharmaceuticals that are successful for many disease therapies.
Nandakumar Selvasudha, Joseph Pushpa Sweety, Gover Antoniraj M, Kandasamy Ruckmani   +3 more
doaj   +1 more source

Estudio de la correlación in vitro – in vivo de la liberación de 6-metilcumarina a partir de un sistema micropartículado [PDF]

, 2016
La correlación in vitro – in vivo, es el establecimiento de un modelo matemático predictivo que describe la relación entre una característica del perfil de liberación in vitro y una respuesta in vivo, generalmente en términos del comportamiento ...
Cárdenas Cuadros, Paola Andrea
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Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process

, 2016
The attention and interest in establishing in vivo/in vitro correlations (IVIVCs) is grounded in its tremendous utility as a prognostic tool. It can be used to support formulation optimization, predict in vivo drug exposure across a potential patient ...
Mistry, B, Martinez, NM, Jamei, M, Patel, N, Rostami-Hochaghan, Amin   +4 more
core   +1 more source