Results 91 to 100 of about 1,092 (147)

Biowaiver Based on the Biopharmaceutical Classification System: Regulatory Basis and Limits of Scientific Interpretation (Review)

Регуляторные исследования и экспертиза лекарственных средств
INRODUCTION. Biowaiver procedure based on the biopharmaceutics classification system (BCS) is widely used in regulatory practice when assessing the bioequivalence of generic medicinal products (GMPs).
N. J. Dahma, E. T. Zhilyakova, D. A. Fadeeva, M. J. Dahma, R. Alrouhayyah, K. A. Nikitin   +5 more
doaj   +1 more source

IN VITRO IN VIVO CORRELATION OF DEXTROMETHORPHAN HYDROBROMIDE MODIFIED RELEASE TABLETS: AN INTERNAL VALIDATION EVALUATION

, 2015
Objectives: The purpose of this study was to develop and validate in vitro and in vivo correlation (IVIVC) for newly developed dextromethorphanhydrobromide sustained-release (SR).Methods: During the development of a once-daily SR tablet of ...
N, Ramesh, Nainar Meyyanathan, Subramania, Rajan, Sekar, Colaco, Socorrina, Shabaraya, Ramakrishna   +4 more
core  

Predicting Arsenic Relative Bioavailability Using Multiple in Vitro Assays: Validation of in Vivo–in Vitro Correlations

, 2015
In this study, previously established arsenic (As) in vivo–in vitro correlations (IVIVC) were assessed for their validity using an independent data set comprising As relative bioavailability (RBA) and bioaccessibility values for 13 herbicide- and mine ...
Paul Herde (1531822), Euan Smith (1482202), Albert L. Juhasz (1482214), Carina Herde (1531819), John Boland (1531825)   +4 more
core   +1 more source

Combined Models for Data from In Vitro-In Vivo Correlation Experiments

, 2008
A method is presented to describe the in vitro-in vivo correlation (IVIVC) of an extended release drug formulation. This extended release drug product is overencapsulated with immediate release material. The heterogeneity of the capsule is modelled using
Dunne, Adrian, STRAETEMANS, Roel, JACOBS, Tom, BIJNENS, Luc, Rossenu, Stefaan, MOLENBERGHS, Geert   +5 more
core   +1 more source

Product Evaluation of Carbamazepine 200mg Controlled Release Tablets using an in vitro-in vivo Correlation Simulation Model

, 2020
Evaluation of the dissolution characteristics of drugs and their bioavailability can be conducted using an in vitro-in vivo correlation model. This can help in assessing the products available in the market for quality.
Ndwigah, Stanley N., Kiuri, Julius N., Maru, Shital M.   +2 more
core  

Comparisons of in vitro Fick’s first law, lipolysis, and in vivo rat models for oral absorption on BCS II drugs in SNEDDS

International Journal of Nanomedicine, 2019
Jingyi Ye,1,* Huiyi Wu,1,* Chuanli Huang,1 Wanting Lin,2 Caifeng Zhang,1 Bei Huang,2 Banyi Lu,2 Hongyu Xu,2 Xiaoling Li,3 Xiaoying Long1,41Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People&
Ye J, Wu H, Huang C, Lin W, Zhang C, Huang B, Lu B, Xu H, Li X, Long X   +9 more
doaj  

Sublingual drug delivery: In vitro-in vivo correlation

, 2013
Administration of drugs sublingually allows direct absorption into the systemic circulation which results in quick onset of action and a higher bioavailability as a consequence of by-passing first pass metabolism.
Kaur, Navdeep
core  

In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase

, 2020
The metabolism of the 5-lipoxygenase (5-LOX) inhibitor, CJ-13,610, was investigated in liver microsomes from human and pre-clinical species, in effort to compare metabolite profiles, and evaluate the in vitro-in vivo correlation (IVIVC) for metabolic ...
J Matthew Hutzler, Collette D Linder, J S D, J Scott Daniels, Roger J Melton, St Laboratories, John Vincent, Dr J Matthew Hutzler, C D L, St Louis Development, R J M, Missouri Louis, J M H   +12 more
core  

Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM). [PDF]

Eur J Pharm Sci, 2012
Patel AR, Spencer SD, Chougule MB, Safe S, Singh M.   +4 more
europepmc   +1 more source

Microstructural Characterization and In Vitro-In Vivo Evaluation of Drug Release and Permeation in Goupi Plaster. [PDF]

Pharmaceutics
Liu J, Guan T, Zhang A, Liu Y, Yang Z, Guan F, Li W, Wang Y.   +7 more
europepmc   +1 more source