Results 81 to 90 of about 1,092 (147)

Biopharmaceutical Classification System in In-vitro/In-vivo Correlation: Concept and Development Strategies in Drug Delivery

, 2012
Drug development is a very laborious and expensive process. One of the major reasons for failure during the clinical phases of drug development is inadequate pharmacokinetic data on the drug candidate.
Rajiah, Kingston, Nainar, Sundaramoorthi, Angamuthu, Santhosam, Kasibhatta, Ravisekhar, Prabakara, Dn   +4 more
core   +3 more sources

Preparation and In Vitro/In Vivo Evaluation of Microparticle Formulations Containing Meloxicam

, 2011
In this study, we have formulated chitosan-coated sodium alginate microparticles containing meloxicam (MLX) and aimed to investigate the correlation between in vitro release and in vivo absorbed percentages of meloxicam.
Eroglu, Hakan, Burul-Bozkurt, Nihan, Oner, Levent, Uma, Serdar, Nihan Burul-Bozkurt, Levent Oner, Serdar Uma, Hakan Eroglu   +7 more
core   +1 more source

In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine

, 2015
This work illustrates the use of Physiologically-Based Toxicokinetic (PBTK) modelling in in vitro-to-in vivo correlation (IVIVC) of kinetic measures of caffeine skin penetration and liver metabolism, as well as dose metrics of caffeine-induced HepaRG ...
SALA BENITO Jose', PAINI Alicia, BURTON Julien, URANI Chiara, GAJEWSKA Monika, BRIESEN Heiko, WORTH Andrew, SCHRAMM Karl-Werner   +7 more
core   +1 more source

Relationship between Pb relative bioavailability and bioaccessibility in phosphate amended soil: Uncertainty associated with predicting Pb immobilization efficacy using in vitro assays

Environment International, 2019
In this study, an in vitro in vivo correlation (IVIVC) between Pb in vitro bioaccessibility (IVBA) and relative bioavailability (RBA) was explored to determine whether the efficacy of Pb immobilization in phosphate amended soils could be predicted using ...
Farzana Kastury, Silvia Placitu, John Boland, Ranju R. Karna, Kirk G. Scheckel, Euan Smith, Albert L. Juhasz   +6 more
doaj   +1 more source

STUDY ON IN VIVO RELEASE AND IN VIVO ABSORPTION OF CAMPTOTHECIN-LOADED POLYMERIC NANOPARTICLES: LEVEL A IN VITRO - IN VIVO CORRELATION

, 2016
Objectives: The aim of this study was to develop an in vitro - in vivo correlation (IVIVC) for the prepared Camptothecin (CPT)-loaded polymericnanoformulation.Methods: In this study, CPT-loaded polymeric nanoformulation was prepared by nanoprecipitation ...
MANIKANDAN, MAHALINGAM, KANNAN, KRISHNAMOORTHY   +1 more
core  

Development & validation of level A: In-vitro and in-vivo correlation for ofloxacin using a systematic approach

241-245The key objective of the current research is to establish an IVIVC (in vitro and in vivo correlation) model for ofloxacin tablet formulations.
Padwal, Neha, Makadiya, Nidhi, Swami, Arti   +2 more
core   +1 more source

Development of a Physiologically Relevant Population Pharmacokinetic in Vitro–in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation

, 2016
Establishing a level A in vitro–in vivo correlation (IVIVC) for a drug with complex absorption kinetics is challenging. The objective of the present study was to develop an IVIVC approach based on population pharmacokinetic (POP-PK) modeling that ...
Soyoung Shin (669783), Sun Dong Yoo (3393701), Jürgen B. Bulitta (1647445), Yu Seok Youn (1701235), Tae Hwan Kim (303689), Beom Soo Shin (3393704)   +5 more
core   +1 more source

Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of Ambroxol

Journal of Excipients and Food Chemicals, 2016
An oral controlled release (CR) matrix system of Ambroxol hydrochloride was developed using a binary hydrophilic polymer mixture of chitosan (CH) and xanthan gum (XG) (1:1 w/w ratio).
Mayyas Al Remawi, Faisal Al-Akayleh, Mutaz S. Salem, Munther Al Shami, Adnan Badwan   +4 more
doaj  

Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers

, 2004
The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based on Carbopol 971P and Carbopol 71G was investigated.
Parojčić, Jelena, Jovanović, D, Durić, J, Jovanović, M, Ibrić, Svetlana   +4 more
core   +1 more source

Validation of in vivo-in vitro correlation for modified release tablet containing sodium diclofenac

, 2012
A dissolução de fármacos administrados por via oral é pré-requisito para sua absorção e eficácia clínica. Esta constatação fornece a base para as tentativas de estabelecer correlações entre a dissolução in vitro e a biodisponibilidade in vivo de ...
Rafael da Silva Melo, Melo, Rafael da Silva   +1 more
core   +1 more source