Results 81 to 90 of about 74,947 (311)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Prediction of apparent total tract digestion of crude protein in adult dogs

Journal of Animal Science and Technology
To predict the apparent total tract digestibility (ATTD) of crude protein (CP) in dogs we developed an in vitro system using an in vitro digestion method and a statistical analysis.
Kangmin Seo, Hyun-Woo Cho, Min Young Lee, Chan Ho Kim, Ki Hyun Kim, Ju Lan Chun   +5 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Feeding value of different plant functional types of oak mediterranean ecosystems [PDF]

, 2018
N/
Castro, M.
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

FACTORS AFFECTING THE FIRST STAGE DIGESTION OF FORAGES USING FAECAL LIQUOR

Pakistan Veterinary Journal, 2003
An experiment was carried out to study the effect of duration of incubation on the digestibility with the aim to reduce the time of incubation of the first stage digestion.
A.A. Solangi
doaj  

In-vitro screening of Kalahari browse species for rumen methane mitigation

Scientia Agricola, 2015
The nutritional value of browse foliage from the Thorny Kalahari Dune Bush veld of South Africa is not characterized. Most of this browse species is rich in tannin, but still palatable, and is consumed by ruminants during the dry season, as well as ...
Jacobus Johannes Francois Theart, Abubeker Hassen, Willem Adriaan van Niekerk, Belete Shenkute Gemeda   +3 more
doaj   +1 more source

Beef production from feedstuffs conserved using new technologies to reduce negative environmental impacts [PDF]

, 2007
End of project reportMost (ca. 86%) Irish farms make some silage. Besides directly providing feed for livestock, the provision of grass silage within integrated grassland systems makes an important positive contribution to effective grazing management ...
Black, Alistair D, Boland, T. M., Buttimer, Anne, Crosson, Paul, Crowley, James C., Drennan, Michael J, Forristal, Dermot, Hackett, Richard, Hamilton, William J., Keane, George P., Little, Enda, McGee, Mark, Moloney, Aidan P, Nolan, William, O'Brien, Martin, O'Kiely, Padraig, O'Mara, Frank P., O'Riordan, Edward G., Rice, B., Rotz, C. Alan, Schulte, Rogier P., Stacey, Pamela, Wallace, Michael, Walsh, Karl   +23 more
core  

Different carbohydrate sources affect swine performance and post-prandial glycaemic response [PDF]

, 2020
The type of starch and fibre in the diet affects several parameters, including glycaemic and insulin response, that are involved in pig growth performance.
Calabro S., Cutrignelli M. I., Infascelli F., Lombardi P., Mastellone V., Musco N., Tudisco R., Vastolo A.   +7 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source