Insights into the biopharmaceutical behavior of oral lipid-based formulations using advanced analytical techniques and mathematical modeling [PDF]
Lipid-based formulations (LBFs) are effective means for the oral delivery of poorly water-soluble compounds. The drug is already solubilized in the formulation and, thus, the critical dissolution step is circumvented. However, the oral bioavailability is
Stillhart, Cordula Edith
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The effect of replacing a synthetic antioxidant with a natural extract of yerba mate (Ilex paraguariensis) in frozen burgers stored for 60 days was evaluated. FTIR and GC/MS analyses confirmed the presence of phenolic compounds in the extract.
Andresa Carla Feihrmann +9 more
doaj +1 more source
The effect of enzyme treatment on the in vitro fermentation of Lucerne incubated with equine faecal inocula [PDF]
A series of experiments was conducted to determine the effects of a fibrolytic enzyme preparation (enzyme 1; E1) on the in vitro fermentation of lucerne incubated with equine faecal inocula.
Moore-Colyer, Meriel J. S. +10 more
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Preparation of Curcumin Nanoemulsion and Its in Vitro Simulated Digestion Characteristics
In this study, a stable curcumin nanoemulsion delivery system was constructed using selectively hydrolyzed soy protein as the emulsifier to enhance the aqueous solubility and bioavailability of curcumin.
Xin WAN +4 more
doaj +1 more source
Heavy metal bioavailability and bioaccessibility in soil [PDF]
This chapter considers the use of a variety of approaches to assess either the bioavailability or the bioaccessibility of metals in soil. The bioavailability of metals from soils is considered with respect to a series of single-extraction methods ...
Dean, John, John Richard Dean
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Assessment of errors in cetacean diet analysis: in vitro digestion of otoliths [PDF]
Research into the feeding habits of cetaceans has traditionally relied on examining samples taken from the digestive tracts of commercially caught or stranded and by-caught animals. This depends on the identification and measurement of hard parts such as
Santos, M. B. +2 more
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Preparation and in Vitro Digestibility of Pumpkin Peel Polysaccharide Chromium (III) Complex
In the study, pumpkin peel polysaccharide was extracted by hot water extraction, and a novel pumpkin peel polysaccharide chromium (III) [PPP-Cr(III)] complex was synthesized combined with trivalent chromium ions.
Wen ZHANG +5 more
doaj +1 more source
Adding neutral or anionic hydrocolloids to dairy proteins underin vitro gastric digestion conditions [PDF]
The effect of adding uncharged polysaccharides such as konjac glucomannan (KGM) or negatively charged polysaccharides such as alginate to dairy protein ingredients - milk, whey proteins and calcium caseinate - was investigated through simulated in vitro ...
Larrea Santos, Virginia +3 more
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Susceptibility of lysozyme to in-vitro digestion and immunoreactivity of its digests [PDF]
This paper examines lysozyme (LYS) behaviour upon in-vitro digestion, mimicking different conditions in the stomach and intestine, and assessing the effect of natural surfactants, such as phosphatidylcholine (PC) or bile salts (BS), on hydrolysis and residual immunogenicity of the digests.
Jiménez Saiz, Rodrigo +4 more
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In vitro lipid digestion models
The models are evaluated in terms of their suitability to assess lipid based drug delivery systems, and their ability to produce In vitro - in vivo correlations (IVIVCs). While the pH-stat lipolysis model is by far the most commonly utilized In vitro digestion model in relation to characterizing Lipid based drug delivery Presently, no single In vitro ...
Kethavath Bhagya, M. Sunitha Reddy
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