Results 71 to 80 of about 95,000 (312)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Immunomodulation Properties of Solid-State Fermented Laetiporussulphureus Ethanol Extracts in Chicken Peripheral Blood Monocytes In Vitro [PDF]

Brazilian Journal of Poultry Science, 2019
Laetiporus sp. is recognized as a fungal species traditionally used for medicinal purposes. This study investigated the in-vitro effects of solid-state fermented Laetiporussulphureus ethanol extracts (LSE) for their immunomodulatory potential.
WC Lin, MT Lee, LJ Lin, SC Chang, TT Lee
doaj   +2 more sources

Bioactivity of tempe by inhibiting adhesion of ETEC to intestinal cells, as influenced by fermentation substrates and starter pure cultures [PDF]

, 2010
Soya bean tempe is known for its bioactivity in reducing the severity of diarrhoea in piglets. This bioactivity is caused by an inhibition of the adhesion of enterotoxigenic Escherichia coli (ETEC) to intestinal cells.
Nout, M.J.R., Roubos-van den Hil, P.J., Meulen, J., van der, Gruppen, H.   +3 more
core   +1 more source

In Vitro Fermentation and Degradation Characteristics of Rosemary Extract in Total Mixed Ration of Lactating Dairy Cows [PDF]

, 2022
Rosemary extract (RE) is characterized as an antioxidant, and it has the potential to reduce methane emission and change microbial fermentation. Hence, to the extent of the evaluation of RE in ruminant nutrition, the in vitro fermentation technique was ...
Yajing Wang, Shengli Li, Fanlin Kong, Zhijun Cao, Wei Wang, Shuo Wang   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Potential of eucalyptus (Eucalyptus camaldulensis) essential oil to modify in vitro rumen fermentation in sheep

Journal of Applied Animal Research, 2018
This study aimed to evaluate the effects of increasing doses (0, 10, 20, 40, 80 and 120 µl/50 ml) of essential oil of Eucalyptus (Eucalyptus camaldulensis) on in vitro rumen fermentation.
Rana Chouchen, Khaoula Attia, Cyrine Darej, Nizar Moujahed   +3 more
doaj   +1 more source

Screening the Carbon Source Type in Solid-State Fermentation with Phanerochaete chrysosporium to Improve the Forage Value of Corn Straw and Rice Straw

Animals, 2023
Poor quality straw can be made more digestible and palatable through delignification using white rot fungi as a biological treatment in SSF. The decomposition of organic matter by white rot fungi is improved when a carbon source is added.
Ying Wang, Jia Yu, Qiang Li, Junfang Zhang, Sajida Naseem, Bin Sun, Lin Tang, Seongho Choi, Xiangzi Li   +8 more
doaj   +1 more source

Fermentability coefficient of tropical forages and fermentative profile and in vitro degradability of silages

Scientific Reports
Our objective was to determine the fermentability coefficient (FC) of different tropical forages and the fermentative profile, chemical composition, and in vitro degradability of their silages. A randomised block design was used, with five treatments and four repetitions.
Alves, Wagner Sousa, de Lima Cruz, Gabriel Ferreira, de Freitas, Rafael Lelis, da Silveira, Tamara Chagas, Coutinho, Danielle Nascimento, Roseira, João Paulo Santos, Teixeira, Thiago Neves, Rigueira, João Paulo Sampaio, Pereira, Odilon Gomes, Ribeiro, Karina Guimarães   +9 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Probiotic fermentation improves the bioactivities and bioaccessibility of polyphenols in Dendrobium officinale under in vitro simulated gastrointestinal digestion and fecal fermentation

Frontiers in Nutrition, 2022
The objective of the research was to investigate and compare the bioactivities and bioaccessibility of the polyphenols (PPs) from Dendrobium officinale (DO) and probiotic fermented Dendrobium officinale (FDO), by using in vitro simulated digestion model ...
Rurui Li, Rurui Li, Zhenxing Wang, Zhenxing Wang, Kin Weng Kong, Ping Xiang, Xiahong He, Xiahong He, Xuechun Zhang, Xuechun Zhang   +9 more
doaj   +1 more source