Results 81 to 90 of about 701,007 (399)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

, 2020
Stem-cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human pluripotent stem cells (hPSCs) differentiate into pancreatic islets in vitro by profiling DNA ...
Alvarez-Dominguez, J., Charlton, J., Donaghey, J., Helman, A., Kenty, J., Meissner, A., Melton, D., Rasouli, N., Straubhaar, J.   +8 more
core   +1 more source

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R., Hutter, J., Krombach, F., Moosmann, S., Moser, C.   +4 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Human oocyte capacitation culture: Essential step toward hormone‐free assisted reproductive technology

Reproductive Medicine and Biology
Background In vitro oocyte maturation (IVM) is not a novel concept; however, its wide‐scale practice has been limited because of the lower clinical outcomes compared to conventional assisted reproductive technologies.
Johan Smitz, Flor Sánchez, Sergio Romero, Heidi Van Ranst, Ellen Anckaert, Robert B. Gilchrist, Tuong M. Ho, Lan N. Vuong, Yoshiharu Morimoto   +8 more
doaj   +1 more source

Quercetin Efficacy on in vitro Maturation of Porcine Oocytes

Scientific Papers Animal Science and Biotechnologies, 2023
The present study proposed to examine the effects of a polyphenol (quercetin) on in vitro maturated parameters. Quercetin it has been extensively studied by researchers on animals over the 35 years.
Delia Orlovschi, Ileana Miclea, Marius Zahan, Vasile Miclea, Anamaria Pernes   +4 more
doaj  

Human in vitro models for understanding mechanisms of autism spectrum disorder. [PDF]

, 2020
Early brain development is a critical epoch for the development of autism spectrum disorder (ASD). In vivo animal models have, until recently, been the principal tool used to study early brain development and the changes occurring in neurodevelopmental ...
Geschwind, Daniel H, Gordon, Aaron
core  

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

In vitro blastocyst development of post-thaw vitrified bovine oocytes [PDF]

Veterinary World, 2013
Aim: To evaluate the developmental competence of post-thaw vitrified bovine cumulus-oocyte complexes (COCs) in vitro.Materials and Methods: A total of 129 COCs were cryopreserved using vitrification solution comprising of 15% ethylene glycol (EG) + 15 ...
D. J. Dutta,, Hiramoni Dev, Himangshu Raj   +2 more
doaj   +1 more source

Modulation of the effectiveness of 17-alpha-hydroxy-20-beta-dihydroprogesterone or of a gonadotrophic extract on the in vitro intrafollicular maturation of oocytes of the rainbow trout Salmo gairdnerii by various non-maturing steroids [Translation from: Compte Rendu Hebdomadaire des Seances de l'Academie des Sciences, Paris, Series D 281, 811-814, 1975] [PDF]

, 1980
The effectiveness of 17 α-hydroxy-20 β-dihydroprogesterone (17 α-20 β Pg) or of a trout hypophyseal gonadotrophic extract on the in vitro intrafollicular maturation of trout oocytes can be modulated by steroids which do not have a direct maturing effect;
Jalabert, B.
core