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Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Lymphangiogenesis is a stage of new lymphatic vessel formation in development and pathology, such as inflammation and tumor metastasis. Physiologically relevant models of lymphatic vessels have been in demand because studies on lymphatic vessels are ...
Youngkyu Cho +9 more
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Unlocking the Potential of Stem Cell Microenvironments In Vitro [PDF]
BioengineeringThe field of regenerative medicine has recently witnessed groundbreaking advancements that hold immense promise for treating a wide range of diseases and injuries. At the forefront of this revolutionary progress are stem cells. Stem cells typically reside in specialized environments in vivo, known as microenvironments or niches, which play critical ...
Chiara Scodellaro +4 more
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Hydrogels to model 3D in vitro microenvironment of tumor vascularization. [PDF]
Adv Drug Deliv Rev, 2014 A growing number of failing clinical trials for cancer therapy are substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is
Song HH, Park KM, Gerecht S.
europepmc +4 more sources
Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment. [PDF]
PLoS ONE, 2018 Vasculature is an interface between the circulation and the hematopoietic tissue providing the means for hundreds of billions of blood cells to enter the circulation every day in a regulated fashion.
Surya Kotha +10 more
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Effect of Mechanical Microenvironment on Collagen Self-Assembly In Vitro
Journal of Functional Biomaterials, 2023 Collagen, as a structural protein, is widely distributed in the human body. Many factors influence collagen self-assembly in vitro, including physical-chemical conditions and mechanical microenvironment, and play a key role in driving the structure and ...
Leihan Han +5 more
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The Biofabrication of Diseased Artery In Vitro Models
Micromachines, 2022 As the leading causes of global death, cardiovascular diseases are generally initiated by artery-related disorders such as atherosclerosis, thrombosis, and aneurysm.
Chen Pan +4 more
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Modeling Tumor Microenvironments In Vitro [PDF]
Journal of Biomechanical Engineering, 2014 Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix, stromal cells, immune cells, progenitor cells, and blood and lymphatic vessels.
Mingming Wu, Melody A. Swartz
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Behaviors of Glioblastoma Cells in in Vitro Microenvironments [PDF]
Scientific Reports, 2019 AbstractGlioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus ...
Wenwen Diao +11 more
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Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models
Cells, 2021 Hypoxia is the most common microenvironment feature of lung cancer tumors, which affects cancer progression, metastasis and metabolism. Oxygen induces both proteomic and genomic changes within tumor cells, which cause many alternations in the tumor ...
Iwona Ziółkowska-Suchanek
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Hydrogels to engineer tumor microenvironmentsin vitro
Biomaterials Science, 2021 Illustration of engineered hydrogel to recapitulate aspects of the tumor microenvironment.
Kanishka Fernando +3 more
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