Results 11 to 20 of about 332,871 (312)
Tumor heterogeneity: preclinical models, emerging technologies, and future applications
Frontiers in Oncology, 2023 Heterogeneity describes the differences among cancer cells within and between tumors. It refers to cancer cells describing variations in morphology, transcriptional profiles, metabolism, and metastatic potential. More recently, the field has included the
Marco Proietto +14 more
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Improving Bioprinted Volumetric Tumor Microenvironments In Vitro
Trends in Cancer, 2020 Despite the great breakthroughs in the past few decades in illuminating the pathological mechanisms of cancer and in developing new anticancer drugs, it remains extremely challenging to cure most cancers. Therefore, it is imperative to develop more sophisticated and more biomimetic preclinical cancer models.
Jun Li +3 more
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Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration
Stem Cells International, 2021 The microenvironment, or niche, regulates stem cell fate and improves differentiation efficiency. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are ideal cell source for bone tissue engineering.
Lingling E +11 more
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In Vitro 3D Cultures to Model the Tumor Microenvironment
Cancers, 2021 It is now well established that the tumor microenvironment plays a key role in determining cancer growth, metastasis and drug resistance. Thus, it is fundamental to understand how cancer cells interact and communicate with their stroma and how this crosstalk regulates disease initiation and progression.
Fontana F. +4 more
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Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine
Micromachines, 2021 The complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in
Jisoo Kim, Jinah Jang, Dong-Woo Cho
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Transplantation of mouse iPSCs into testis of azoospermic mouse model: in vivo and in vitro study
Artificial Cells, Nanomedicine, and Biotechnology, 2019 This study aimed to induce spermatogenesis in azoospermic testis through induced pluripotent stem cells (iPSCs) derived spermatogonial stem cell-like cells (SSCLCs) after iPSCs in vivo and in vitro transplantation and three-dimensional organ culture. DiI-
Forouzan Rahmani +3 more
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Application of microfluidic chips in the simulation of the urinary system microenvironment
Materials Today Bio, 2023 The urinary system, comprising the kidneys, ureters, bladder, and urethra, has a unique mechanical and fluid microenvironment, which is essential to the urinary system growth and development.
Changhao Hou +9 more
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Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To establish an in vitro culture model mimicking tumor microenvironment using hydrogel microspheres and fresh primary pancreatic cancer cells.Methods·The morphological distribution of the hydrogel microspheres was recorded, observed and ...
MA Fangfang +6 more
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Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models
Journal of Experimental & Clinical Cancer Research, 2020 The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which modulate several intrinsic TME elements to ...
Somshuvra Bhattacharya +2 more
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Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells. [PDF]
PLoS ONE, 2014 In vitro and in vivo models are widely used in cancer research. Characterizing the similarities and differences between a patient's tumor and corresponding in vitro and in vivo models is important for understanding the potential clinical relevance of ...
Mehmet Baysan +13 more
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