Results 21 to 30 of about 332,871 (312)
Fabrication of 3D Controlled in vitro Microenvironments
MethodsX, 2014 Microfluidics-based lab-on-a-chips have many advantages, one of which is to provide physiologically relevant settings for cell biology experiments. Thus there is an ever increasing interest in their fabrication. Our goal is to construct three dimensional (3D) Controlled in vitro Microenvironments (CivMs) that mimic the in vivo microenvironments.
Berrin Ozdil +3 more
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Recent Progress in Microfluidic Models of the Blood-Brain Barrier
Micromachines, 2019 The blood-brain barrier (BBB) is a critical physical and chemical barrier that maintains brain homeostasis. Researchers in academia and industry are highly motivated to develop experimental models that can accurately mimic the physiological ...
Lili Jiang +4 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Hematopoietic stem cells (HSCs) provide a life-long supply of haemopoietic cells and are indispensable for clinical transplantation in the treatment of malignant hematological diseases.
Xiaochan Huang +7 more
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3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
Disease Models & Mechanisms, 2017 Even with many advances in treatment over the past decades, cancer still remains a leading cause of death worldwide. Despite the recognized relationship between metastasis and increased mortality rate, surprisingly little is known about the exact ...
Jacob L. Albritton, Jordan S. Miller
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Breast Cancer Research, 2023 Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity contributes to breast cancer remains unclear.
Rhianna Rachael Romany Blyth +2 more
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In Vitro Modeling of the Tumor Microenvironment in Tumor Organoids
Tissue Engineering and Regenerative Medicine, 2020 The tumor microenvironment (TME) represents the many components occupying the space within and surrounding a tumor, including cells, signaling factors, extracellular matrix, and vasculature. Each component has the potential to assume many forms and functions which in turn contribute to the overall state of the TME, and further contribute to the ...
Mahesh, Devarasetty +3 more
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Biomimetic Strategies for the Glioblastoma Microenvironment
Frontiers in Materials, 2017 Glioblastoma multiforme (GBM) is a devastating type of tumor with high mortality, caused by extensive infiltration into adjacent tissue and rapid recurrence.
Junghwa Cha, Pilnam Kim
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Progress in mimicking brain microenvironments to understand and treat neurological disorders
APL Bioengineering, 2021 Neurological disorders including traumatic brain injury, stroke, primary and metastatic brain tumors, and neurodegenerative diseases affect millions of people worldwide. Disease progression is accompanied by changes in the brain microenvironment, but how
Mai T. Ngo, Brendan A. C. Harley
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In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead?
CellsHaematological malignancies comprise a diverse group of life-threatening systemic diseases, including leukaemia, lymphoma, and multiple myeloma. Currently available therapies, including chemotherapy, immunotherapy, and CAR-T cells, are often associated ...
Carlotta Mattioda +3 more
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In vitro microglia models: the era of engineered cell microenvironments
Neural Regeneration Research, 2022 Micro and Nano ...
Sharaf, A.M.S.E. (author) +3 more
openaire +4 more sources