Results 31 to 40 of about 332,871 (312)

Modeling of brain tumors using in vitro, in vivo, and microfluidic models: A review of the current developments

Heliyon
Brain cancers are some of the most complex diseases to treat, despite the numerous advances science has made in cancer chemotherapy and research. One of the key obstacles to identifying potential cures for this disease is the difficulty in emulating the ...
Richu Raju R, Nour M. AlSawaftah, Ghaleb A. Husseini   +2 more
doaj   +1 more source

A computational diffusion model to study antibody transport within reconstructed tumor microenvironments

BMC Bioinformatics, 2020
Background Antibodies revolutionized cancer treatment over the past decades. Despite their successfully application, there are still challenges to overcome to improve efficacy, such as the heterogeneous distribution of antibodies within tumors.
Ana Luísa Cartaxo, Jaime Almeida, Emilio J. Gualda, Maria Marsal, Pablo Loza-Alvarez, Catarina Brito, Inês A. Isidro   +6 more
doaj   +1 more source

Intestine‐on‐a‐chip for intestinal disease study and pharmacological research

View, 2023
Intestinal diseases seriously affect the quality of life. The assays for intestinal disease study based on two‐dimensional in vitro cell culture and animal models fail to model human physiology and pathophysiology accurately. As a bridge between in vitro
Dongxue Zhang, Liang Qiao
doaj   +1 more source

Advances on the roles of tumor microenvironment in bone cancer pain [PDF]

Jichu yixue yu linchuang, 2021
Tumor microenvironment (TME) is the in vitro microenvironment in which tumors live. Cancer-induced bone pain(CIBP) is one of the most common symptoms of tumor bone metastasis.
ZHOU Jia-hong, LI Min
doaj  

Defined Microenvironments Trigger In Vitro Gastrulation in Human Pluripotent Stem Cells

Advanced Science, 2022
Abstract Gastrulation is a stage in embryo development where three germ layers arise to dictate the human body plan. In vitro models of gastrulation have been demonstrated by treating pluripotent stem cells with soluble morphogens to trigger differentiation.
Pallavi Srivastava, Sara Romanazzo, Chantal Kopecky, Stephanie Nemec, Jake Ireland, Thomas G. Molley, Kang Lin, Pavithra B. Jayathilaka, Elvis Pandzic, Avani Yeola, Vashe Chandrakanthan, John Pimanda, Kristopher Kilian   +12 more
openaire   +3 more sources

Acidic Microenvironment Regulates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating the Generation and Function of Tregs via the PI3K-mTOR Pathway

Frontiers in Immunology, 2020
Hepatic ischemia/reperfusion injury (HIRI) is a major cause of liver dysfunction and even liver failure after liver transplantation and hepatectomy. One of the critical mechanisms that lead to HIRI is an acidic microenvironment, which develops due to the
Xiaojie Gan, Xiaojie Gan, Xiaojie Gan, Xiaojie Gan, Rongsheng Zhang, Rongsheng Zhang, Rongsheng Zhang, Rongsheng Zhang, Jian Gu, Jian Gu, Jian Gu, Jian Gu, Zheng Ju, Zheng Ju, Zheng Ju, Zheng Ju, Xiao Wu, Xiao Wu, Xiao Wu, Xiao Wu, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Hao Peng, Hao Peng, Hao Peng, Hao Peng, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Jinren Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Feng Cheng, Feng Cheng, Feng Cheng, Feng Cheng, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +43 more
doaj   +1 more source

Tumor Microenvironment – Possibilities of the Research Under In Vitro Conditions [PDF]

Klinicka onkologie, 2014
Tumorigenesis is always accompanied by alterations of the microenvironment in the respective tissue. The tumor microenvironment represents a heterogeneous complex, in which cell proliferation, differentiation, necrosis or apoptosis are regulated by various extracellular stimuli, and it can also lead to development of an aggressive phenotype of tumor ...
P, Chlapek, S, Chovanová, V, Sláviková, R, Veselská   +3 more
openaire   +2 more sources

The tendon microenvironment: Engineered in vitro models to study cellular crosstalk

Advanced Drug Delivery Reviews, 2022
Tendinopathy is a multi-faceted pathology characterized by alterations in tendon microstructure, cellularity and collagen composition. Challenged by the possibility of regenerating pathological or ruptured tendons, the healing mechanisms of this tissue have been widely researched over the past decades.
Gómez-Florit, Manuel, Labrador-Rached, Claudia J., Domingues, Rui Miguel Andrade, Gomes, Manuela E.   +3 more
openaire   +3 more sources

Characterization of 3D heterocellular spheroids of pancreatic ductal adenocarcinoma for the study of cell interactions in the tumor immune microenvironment

Frontiers in Oncology, 2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies nowadays. The available chemo- and immunotherapies are often ineffective in treating PDAC due to its immunosuppressive and highly desmoplastic tumor immune microenvironment ...
Giulio Giustarini, Germaine Teng, Andrea Pavesi, Andrea Pavesi, Giulia Adriani, Giulia Adriani   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source