Results 211 to 220 of about 1,304,931 (266)

3D-printed in vitro models of Stanford type B aortic dissection: A scoping review. [PDF]

J Vasc Surg Cases Innov Tech
Hagedorn MN, Mächerle M, Karl R, Bergt CS, Böckler D, Engelhardt S, Meisenbacher K.   +6 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Nanoparticle Uptake and Crossing by Human In Vitro Models of Intestinal Barriers: A Scoping Review. [PDF]

Nanomaterials (Basel)
Ritarossi C, Prota V, De Battistis F, Battistelli CL, De Angelis I, Andreoli C, Vincentini O.   +6 more
europepmc   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

In vitro models to mimic tumor endothelial cell-mediated immune cell reprogramming in lung adenocarcinoma. [PDF]

J Exp Clin Cancer Res
Krejbich M, Navarro E, Fresquet J, Cotinat M, Isen V, Perdrieau H, Forest V, Doméné A, Delaunay T, Awada H, Dochez V, Roulois D, Boisgerault N, Redon R, Blanquart C, Corre I, Treps L.   +16 more
europepmc   +1 more source

7SK-enriched exosomes suppress the cancer phenotypes in human lung cancer cells: insights from 2D and microfluidic 3D in vitro models. [PDF]

Sci Rep
Aghamiri S, Ajoudanian M, Farhadi S, Sharifi K, Ghanbarian H.   +4 more
europepmc   +1 more source

Immunomodulatory Effects of Juzentaihoto on Fas-Mediated Apoptosis: Insights from Cancer Patients and In Vitro Models. [PDF]

Pharmaceuticals (Basel)
Ngo QT, Espinoza JL, Li H, Inokuchi M, Nakanishi Y, Morishita E, Katagiri T, Kawahara A, Yoshizaki T, Takami A, Ogawa-Ochiai K.   +10 more
europepmc   +1 more source

Bridging the Translational Gap: Rethinking Smooth Muscle Cell Plasticity in Atherosclerosis Through Human-Relevant In Vitro Models. [PDF]

Cells
Som L, Smart N.
europepmc   +1 more source

Imaging-guided platform for real-time intervention in complex in vitro models

Serio A, Joshi S, Moreno-Gonzalez C, Suklai P, Carraro E, Ratcliffe C, Boezio G, Konstantinou G, Cano-Ferrer X, Hagemann C, Kavanagh T, Ameer-beg S, Imbert A, Sahai E, Tedesco F.   +14 more
europepmc   +1 more source