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In Vitro Models of Cutaneous Inflammation
2017The skin plays an essential role in the transmission of Lyme borreliosis since it is the first interface between the Ixodes tick and the host during the inoculation of Borrelia burgdorferi sensu lato. A better understanding of the inflammatory reaction at this location is key to develop better strategies (e.g., vaccine and diagnosis) to fight this ...
Bernard, Quentin +2 more
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An in vitro model of myocardial infarction
Nature Biomedical Engineering, 2020Structural and functional changes following infarction in a human heart can be modelled with human cardiac organoids set in a hypoxic gradient and stimulated with the neurotransmitter noradrenaline.
Mills, Richard, Hudson, James
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1981
Adenocarcinoma of the prostate is the third leading cause of death in the adult human male cancer patient, after cancers of the lung and colon/rectum. The incidence of prostatic cancer has increased by more than 25% in the last 25 years. The number of deaths from prostatic carcinoma in the U.S.A.
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Adenocarcinoma of the prostate is the third leading cause of death in the adult human male cancer patient, after cancers of the lung and colon/rectum. The incidence of prostatic cancer has increased by more than 25% in the last 25 years. The number of deaths from prostatic carcinoma in the U.S.A.
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In vitro models for human neuroglia
Neuroglia are a heterogenous population of cells in the nervous system. In the central nervous system, this group is classified into astrocytes, oligodendrocytes, and microglia. Neuroglia in the peripheral nervous system are divided into Schwann cells and enteric glia. These groups of cells display considerable differences in their developmental origin,Bas, Lendemeijer, Femke M S, de Vrij
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An in vitro model of caloric restriction
Experimental Gerontology, 2003The mechanisms underlying the ability of caloric restriction (CR) to extend life span and enhance stress responsiveness remain elusive. Progress in this area has been slow due to the complexities of using animals for CR studies and assessing life span as the measure of CR effectiveness. It is therefore of great interest to develop in vitro models of CR.
Rafael, de Cabo +5 more
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Development of an in vitro bladder model
Nursing Standard, 1992The first of the three articles in this series (1) expounded the case for a broader approach to research design in nursing. In particular, the experimental approach and the use of laboratory studies were highlighted as areas that nurses have tended to neglect.
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British Journal of Neurosurgery, 2008
Traumatic brain injury (TBI) continues to be an important cause of mortality and morbidity, but its pathophysiology is no longer considered an instantaneous irreversible event occurring at the time of injury. Therein, neuroprotection is the attempt to salvage sublethally injured neurons which subsequently die in post-primary sequelae.
A, Kumaria, C M, Tolias
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Traumatic brain injury (TBI) continues to be an important cause of mortality and morbidity, but its pathophysiology is no longer considered an instantaneous irreversible event occurring at the time of injury. Therein, neuroprotection is the attempt to salvage sublethally injured neurons which subsequently die in post-primary sequelae.
A, Kumaria, C M, Tolias
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An In Vitro Model of Ischemic Stroke
2011Brain stroke is a devastating cerebrovascular disease and ranks as the third most common cause of death and disability in the US. Altered blood-brain barrier (BBB) signaling and permeability characteristics during stroke can increase the risk for life-threatening hemorrhagic transformation or damaging brain edema.
Li, Yang +2 more
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In Vitro Model of Cartilage Degradation
2010This 14-day model of cartilage breakdown involves stimulation of bovine nasal cartilage with a combination of interleukin-1 and oncostatin M. Media is harvested on days 7 and 14 and the conditioned media and remaining cartilage at day 14 assayed for the levels of proteoglycan and collagen fragments using biochemical assays.
Wang, Hui, Tim E, Cawston
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