Results 211 to 220 of about 27,781 (266)
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Mutagenicity of ipriflavone in vivo and in vitro
Food and Chemical Toxicology, 2012Ipriflavone (7-isopropoxy-isoflavone) is a semisynthetic isoflavone derivative from daidzein and prescribed to prevent and treat osteoporosis in postmenopausal women. In the present study, ipriflavone was investigated with regard to their cytotoxic and mutagenic effects using the micronucleus assay (MN) in vivo on cells of bone marrow and peripheral ...
Luciano, Belcavello +4 more
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Mutagenic effects of ribavirin in vivo
Journal of Hepatology, 2005Almost 200 million people worldwide are infected with hepatitis C virus (HCV). For these people treatment options are relatively limited, and they have recently evolved from IFN-a monotherapy to IFN-a/ribavirin to the present standard of PEG-IFN-a/ribavirin combination therapy.
Alan S. Perelson, Ruy M. Ribeiro
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In vivo mutagenicity studies with iodinated glycerol azeo
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1997Previous studies have shown that iodinated glycerol azeo is positive in a number of in vitro mutagenicity assays including the Ames assay (TA100; TA1535), mouse lymphoma assay, Chinese hamster ovary (cytogenetic) assay and in one in vivo study, the sex-linked-recessive-lethal assay in Drosophila.
J H, McGee +2 more
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In vivo cytogenetic effects of cooked food mutagens
Mutation Research/Genetic Toxicology, 1989Using a variety of in vivo cytogenetic endpoints, we have investigated the effects of several compounds formed during the cooking of meat. C57Bl/6 mice were used to test for an increase in the frequency of sister-chromatid exchanges (SCEs), chromosomal aberrations, and micronucleated erythrocytes by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
J D, Tucker +6 more
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Cycasin: Detection of Associated Mutagenic Activity in vivo
Science, 1969Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the host-mediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the ...
M G, Gabridge, A, Denunzio, M S, Legator
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Mutagenicity tests with astemizole in vitro and in vivo
Archives of Toxicology, 1982Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice.
P, Vanparys +3 more
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Mutagenicity tests with domperidone in vitro and in vivo
Toxicology Letters, 1982Abstract Possible induction of chromosomal aberrations by domperidone was studied in vivo by a micronucleus test on mice and a dominant lethal test on both male and female mice. In vitro chromosomal damage was assessed on short-term cultures of human lymphocytes.
P, Vanparys +3 more
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Metabolism and mutagenicity of acrylonitrile: An in vivo study
Environmental Mutagenesis, 1985AbstractThe mutagenic activity present in urine of animals treated with acrylonitrile (ACN) is tentatively related to the excretion of three urinary metabolites: thiocyanate (SCN−), hydroxyethylmercapturic acid (OH‐MA), and cyanoethylmercapturic acid (CN‐MA).
M, Lambotte-Vandepaer +2 more
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Cyclohexylamine mutagenicity: An in vivo evaluation utilizing fetal lambs
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1974Summary The in vivo effects of cyclohexylamine (CHA) upon the segregation apparatus and chromosome morphology of mitogenically capable lymphocytes obtained from the peripheral circulating blood tissue of living fetal lambs in utero were evaluated. CHA proved to be a clastogen in vivo .
J H, Turner, D L, Hutchinson
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Nitrogen-substitution effect on in vivo mutagenicity of chrysene
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2005We have previously reported the in vivo mutagenicity of aza-polycyclic aromatic hydrocarbons (azaPAHs), such as quinoline, benzo[f]quinoline, benzo[h]quinoline, 1,7-phenanthroline and 10-azabenzo[a]pyrene. The 1,10-diazachrysene (1,10-DAC) and 4,10-DAC, nitrogen-substituted analogs of chrysene, were shown to exhibit mutagenicity in Salmonella ...
Katsuya, Yamada +6 more
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