Results 221 to 230 of about 117,900,808 (282)

Molecular dynamics and predictive toxicity insights into theaflavin as a potential inhibitor of MMP-2 and MMP-9 in breast cancer. [PDF]

open access: yesToxicol Rep
Purwowidodo IB   +7 more
europepmc   +1 more source

Mutagenicity of ipriflavone in vivo and in vitro

Food and Chemical Toxicology, 2012
Ipriflavone (7-isopropoxy-isoflavone) is a semisynthetic isoflavone derivative from daidzein and prescribed to prevent and treat osteoporosis in postmenopausal women. In the present study, ipriflavone was investigated with regard to their cytotoxic and mutagenic effects using the micronucleus assay (MN) in vivo on cells of bone marrow and peripheral ...
Luciano, Belcavello   +4 more
openaire   +2 more sources

Mutagenic Effects of Hydroxylamine in vivo

Science, 1965
Hydroxylamine can induce any one of the four types of transition mutations in bacteriophage S13 if the mutagen is added directly to agar plates seeded with phage and bacterial indicators. The phage can also be mutated by treating the host cell with hydroxylamine before infecting it with phage.
I, TESSMAN, H, ISHIWA, S, KUMAR
openaire   +2 more sources

Mutagenicity detection of in vivo nitrosation of dimethylamine by nitrite

Environmental Mutagenesis, 1979
AbstractIn vivo nitrosation of dimethylamine by nitrite was measured with an intrahepatic host‐mediated mutagenicity assay using Salmonella typhimurium as the detecting organism. It was possible to detect the product, N‐nitrosodimethylamine, at much lower doses with this system than with previously reported in vivo systems.
Wen-Zong Whong
exaly   +3 more sources

Mutagenicity tests with astemizole in vitro and in vivo

Archives of Toxicology, 1982
Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice.
P, Vanparys   +3 more
openaire   +2 more sources

Mutagenicity tests with domperidone in vitro and in vivo

Toxicology Letters, 1982
Abstract Possible induction of chromosomal aberrations by domperidone was studied in vivo by a micronucleus test on mice and a dominant lethal test on both male and female mice. In vitro chromosomal damage was assessed on short-term cultures of human lymphocytes.
P, Vanparys   +3 more
openaire   +2 more sources

Nitrogen-substitution effect on in vivo mutagenicity of chrysene

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2005
We have previously reported the in vivo mutagenicity of aza-polycyclic aromatic hydrocarbons (azaPAHs), such as quinoline, benzo[f]quinoline, benzo[h]quinoline, 1,7-phenanthroline and 10-azabenzo[a]pyrene. The 1,10-diazachrysene (1,10-DAC) and 4,10-DAC, nitrogen-substituted analogs of chrysene, were shown to exhibit mutagenicity in Salmonella ...
Takayoshi Suzuki   +2 more
exaly   +3 more sources

In vitro and in vivo assays of isopropanol for mutagenicity

Environmental and Molecular Mutagenesis, 1993
AbstractTo assess the mutagenic potential of isopropanol, an in vitro Chinese hamster ovary (CHO) cell/HGPRT gene mutation assay and a bone marrow micronucleus study in mice were conducted. In the CHO/HGPRT assay, concentration levels ranged from 0.5 to 5.0 mg/ml.
R W, Kapp   +7 more
openaire   +2 more sources

Metabolism and mutagenicity of acrylonitrile: An in vivo study

Environmental Mutagenesis, 1985
AbstractThe mutagenic activity present in urine of animals treated with acrylonitrile (ACN) is tentatively related to the excretion of three urinary metabolites: thiocyanate (SCN−), hydroxyethylmercapturic acid (OH‐MA), and cyanoethylmercapturic acid (CN‐MA).
M, Lambotte-Vandepaer   +2 more
openaire   +2 more sources

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