Results 241 to 250 of about 117,900,808 (282)
Some of the next articles are maybe not open access.
Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver
Archives of Toxicology, 2013The combined effects of various carcinogens found in food products are a concern for human health. In the present study, the effects of flumequine (FL) on the in vivo mutagenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the liver were investigated. Additionally, we attempted to clarify the underlying mechanisms through comprehensive
Takashi Umemura
exaly +3 more sources
Toxicology and Applied Pharmacology, 1980
The possibility that chemicals which are mutagenic in in vitro assays pose a “hidden” threat to humans as mutagens has been suggested. Yet, such in vitro studies do not reflect whole animal defense mechanisms against mutation. Therefore, the effects of dose and route of administration upon in vivo sperm alkylation by chemicals shown to be mutagenic in ...
W T, Stott, P G, Watanabe
openaire +2 more sources
The possibility that chemicals which are mutagenic in in vitro assays pose a “hidden” threat to humans as mutagens has been suggested. Yet, such in vitro studies do not reflect whole animal defense mechanisms against mutation. Therefore, the effects of dose and route of administration upon in vivo sperm alkylation by chemicals shown to be mutagenic in ...
W T, Stott, P G, Watanabe
openaire +2 more sources
Archives of Toxicology, 2018
1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver tumors when administered in the drinking water to rats and mice. However, the mode of action (MOA) of the hepatocarcinogenicity of 1,4-dioxane remains unclear.
Min Gi +9 more
openaire +2 more sources
1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver tumors when administered in the drinking water to rats and mice. However, the mode of action (MOA) of the hepatocarcinogenicity of 1,4-dioxane remains unclear.
Min Gi +9 more
openaire +2 more sources
Possibilities of routine in vivo mutagenicity testing in mammals
Archiv f�r Toxikologie, 1971In general, mutations have a negative effect on man. Considering the great number of substances inducing mutagenic effects in microorganisms and in cell cultures, the question arises whether these substances are a genetic risk for man, too. Final statements concerning this matter should be based on in vivo investigations which fully take into account ...
openaire +2 more sources
The effect of caffeine in the in vivo SCE and micronucleus mutagenicity tests
Mutation Research Letters, 1986Caffeine which was administered per os to outbred mice either twice, 30 and 6 h before sacrifice or once, 30 h before sacrifice, at dose levels of 50, 75 or 100 mg/kg body weight only caused a weak induction of micronuclei at the highest dose. Again a level of 100 mg caffeine per kg body weight was required before a weak but not significant effect ...
H U, Aeschbacher, H, Meier, E, Jaccaud
openaire +2 more sources
Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014Hydroquinone (HQ) is used in skin bleaching agents, hair dyes, and finger nail treatments. Many skin-lightening cosmetics that contain HQ are currently marketed in Japan. Concerns have been expressed regarding health risks to the general population because the carcinogenicity of HQ was previously suggested in animal studies.
Mariko, Matsumoto +6 more
openaire +2 more sources
In vitro and in vivo mutagenicity studies with airborne particulate extracts
Mutation Research/Genetic Toxicology, 1988The contribution of nitro compounds to airborne particulate mutagenicity was studied with Salmonella typhimurium strains TA98, TA98NR, TA98/1,8DNP6. The results obtained indicate that nitropyrenes play a minor role in air particulate mutagenicity. Seasonal variations indicate a relatively greater contribution of nitro compounds to the mutagenicity of ...
R, Crebelli +8 more
openaire +2 more sources
Studies on the mutagenic activity of ascorbic acid in vitro and in vivo
Mutation Research/Genetic Toxicology, 1983In vitro data are presented to show that ascorbic acid does not have intrinsic mutagenicity towards strain TA100 of S. typhimurium if deionized water is used to prepare the incubation medium. The addition of Cu2+ ions to the bacterial medium that contains ascorbic acid, or the use of tap water and ascorbic acid alone, causes a mutagenic and cytotoxic ...
E P, Norkus, W, Kuenzig, A H, Conney
openaire +2 more sources
In Vivo Mutagenicity Testing of Arylboronic Acids and Esters
Environmental and Molecular Mutagenesis, 2019Arylboronic acids and esters (referred to collectively as arylboronic compounds) are commonly used intermediates in the synthesis of pharmaceuticals but pose a challenge for chemical syntheses because they are often positive for bacterial mutagenicity in vitro.
Melisa J, Masuda-Herrera +16 more
openaire +2 more sources
Mutagenicity of dimethylsulfoxide (DMSO): In vivo cytogenetics study in the rat
Teratogenesis, Carcinogenesis, and Mutagenesis, 1981AbstractVarious concentrations (1%, 10%, 50%, and 100%) of laboratory grade dimethylsulfoxide (DMSO) were administered by intraperitoneal injection to male Sprague‐Dawley rats for five consecutive days. Femoral bone marrow cells were harvested 24 hours after the last injection and were analyzed for cytogenetic aberration frequencies including ...
R W, Kapp, B E, Eventoff
openaire +2 more sources