Results 231 to 240 of about 117,900,808 (282)
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Mutagenic effects of ribavirin in vivo
Journal of Hepatology, 2005Almost 200 million people worldwide are infected with hepatitis C virus (HCV). For these people treatment options are relatively limited, and they have recently evolved from IFN-a monotherapy to IFN-a/ribavirin to the present standard of PEG-IFN-a/ribavirin combination therapy.
Alan S. Perelson, Ruy M. Ribeiro
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Activation of the mutagens of beef extract in vitro and in vivo
Mutation Research/Genetic Toxicology, 1980The activation in vitro of the mutagens isolated from beef extract, when tested with Salmonella typhimurium strain TA1538, requires the presence of S9 fractions from livers of PCB- or 3-methylcholanthrene-induced rats. S9 fractions from uninduced rats were unable to activate the mutagens, but no induction was necessary with Swiss albino mice. CD-1 mice
Dolara P +3 more
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Cycasin: Detection of Associated Mutagenic Activity in vivo
Science, 1969Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the host-mediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the ...
M G, Gabridge, A, Denunzio, M S, Legator
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Lack of Mutagenic Effects of Halothane in Mammals In Vivo
Anesthesiology, 1981Rodents were exposed in vivo to various clinical doses of halothane to observe structural chromosome aberrations, micronuclei, sister chromatid exchanges (SCEs), dominant lethal mutations, and interferences with phases of the cell cycle. The frequency of chromosome aberrations in bone marrow cells was not increased after exposing Chinese hamsters to 1 ...
A, Basler, G, Röhrborn
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In vivo cytogenetic effects of cooked food mutagens
Mutation Research/Genetic Toxicology, 1989Using a variety of in vivo cytogenetic endpoints, we have investigated the effects of several compounds formed during the cooking of meat. C57Bl/6 mice were used to test for an increase in the frequency of sister-chromatid exchanges (SCEs), chromosomal aberrations, and micronucleated erythrocytes by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
J D, Tucker +6 more
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In vivo mutagenic interaction of nitrite and ethylenethiourea
Experientia, 1975N-Nitroso-Athylenthioharnstoff induziert Mutationen inSalmonella typhimurium. Diese Verbindung wird im Magen von Mausen aus Natriumnitrit und Athylenthioharnstoff gebildet; ihre Mutagenitat wird mit Hilfe des Mikrokerntests gezeigt.
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In vivo mutagenicity studies with iodinated glycerol azeo
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1997Previous studies have shown that iodinated glycerol azeo is positive in a number of in vitro mutagenicity assays including the Ames assay (TA100; TA1535), mouse lymphoma assay, Chinese hamster ovary (cytogenetic) assay and in one in vivo study, the sex-linked-recessive-lethal assay in Drosophila.
J H, McGee +2 more
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The contribution of exogenous and endogenous mutagens to in vivo mutations
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999There is abundant evidence of the potential for exogenous agents to cause cancer but the proportion of human cancers attributable to defined external agents is uncertain. With rare exceptions it is difficult to demonstrate a role for exogenous agents in increasing mutation above background rates.
A A, Morley, D R, Turner
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A mutagenicity methodology for assessing the formation on N-dimethylnitrosamine in vivo
Mutation Research/Environmental Mutagenesis and Related Subjects, 1981The mutagenicity test methodology in vitro has been extensively used during recent years in the identification of potential carcinogenic agents. Mutagenic analyses have been applied to the study of chemical reaction products for the demonstration of the formation of mutagenic agents.
BARALE, ROBERTO, Zucconi D, Loprieno N.
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A mutagenic in vivo metabolite of sodium azide
Mutation Research/Environmental Mutagenesis and Related Subjects, 1978Experimental evidence is presented for the presence of a mutagenic metabolite formed in vivo in barley embryos exposed to sodium azide. The mutagenic substance found in extracts after removal of free azide by acidification was partially purified by liquid column chromatography and eluted.
W.M. Owais +5 more
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