Results 221 to 230 of about 27,781 (266)

In vivo mutagenic interaction of nitrite and ethylenethiourea

Experientia, 1975
N-Nitroso-Athylenthioharnstoff induziert Mutationen inSalmonella typhimurium. Diese Verbindung wird im Magen von Mausen aus Natriumnitrit und Athylenthioharnstoff gebildet; ihre Mutagenitat wird mit Hilfe des Mikrokerntests gezeigt.
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Mutagenic potential of temozolomide in bone marrow cells in vivo

Blood, 2006
Therapy-related myeloid leukemias (t-MLs) occur in as many as 5% to 10% of patients who are otherwise cured of a primary neoplasm with aggressive multimodal regimens. Many patients with t-MLs or therapy-related myelodysplastic syndrome (t-MDS) have previously received chemotherapeutic agents ...
Hartmut, Geiger, David, Schleimer, Kalpana J, Nattamai, Stefanie R, Dannenmann, Stella M, Davies, Brian D, Weiss   +5 more
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Possibilities of routine in vivo mutagenicity testing in mammals

Archiv f�r Toxikologie, 1971
In general, mutations have a negative effect on man. Considering the great number of substances inducing mutagenic effects in microorganisms and in cell cultures, the question arises whether these substances are a genetic risk for man, too. Final statements concerning this matter should be based on in vivo investigations which fully take into account ...
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Lack of Mutagenic Effects of Halothane in Mammals In Vivo

Anesthesiology, 1981
Rodents were exposed in vivo to various clinical doses of halothane to observe structural chromosome aberrations, micronuclei, sister chromatid exchanges (SCEs), dominant lethal mutations, and interferences with phases of the cell cycle. The frequency of chromosome aberrations in bone marrow cells was not increased after exposing Chinese hamsters to 1 ...
A, Basler, G, Röhrborn
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Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014
Hydroquinone (HQ) is used in skin bleaching agents, hair dyes, and finger nail treatments. Many skin-lightening cosmetics that contain HQ are currently marketed in Japan. Concerns have been expressed regarding health risks to the general population because the carcinogenicity of HQ was previously suggested in animal studies.
Mariko, Matsumoto, Shoji, Masumori, Mutsuko, Hirata-Koizumi, Atsushi, Ono, Masamitsu, Honma, Kazuhito, Yokoyama, Akihiko, Hirose   +6 more
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In vitro and in vivo assays of isopropanol for mutagenicity

Environmental and Molecular Mutagenesis, 1993
AbstractTo assess the mutagenic potential of isopropanol, an in vitro Chinese hamster ovary (CHO) cell/HGPRT gene mutation assay and a bone marrow micronucleus study in mice were conducted. In the CHO/HGPRT assay, concentration levels ranged from 0.5 to 5.0 mg/ml.
R W, Kapp, D J, Marino, T H, Gardiner, L W, Masten, R H, McKee, T R, Tyler, J L, Ivett, R R, Young   +7 more
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EPA use of in vivo germ cell mutagenicity data

Environmental and Molecular Mutagenesis, 1991
AbstractThe Toxic Substances Control Act (TSCA) provides the U.S. Environmental Protection Agency, Office of Toxic Substances (EPA, OTS) with the authority to regulate chemical use by requiring testing and use restrictions as appropriate to protect human health.
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Chemical mutagen testing on in vivo somatic mammalian cells

Agents and Actions, 1973
Possibilities and limitations in the use of in vivo cytogenetic tests on somatic cells are discussed. Special attention is focused on the problems raised by the relative insensivity of the available procedures. It is emphasized that in planning screening tests the accumulated experience from studies with known chromosome breaking chemicals must be ...
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A mutagenic in vivo metabolite of sodium azide

Mutation Research/Environmental Mutagenesis and Related Subjects, 1978
Experimental evidence is presented for the presence of a mutagenic metabolite formed in vivo in barley embryos exposed to sodium azide. The mutagenic substance found in extracts after removal of free azide by acidification was partially purified by liquid column chromatography and eluted.
W.M. Owais, M.A. Zarowitz, R.A. Gunovich, A.L. Hodgdon, A. Kleinhofs, R.A. Nilan   +5 more
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In Vivo Mutagenicity Testing of Arylboronic Acids and Esters

Environmental and Molecular Mutagenesis, 2019
Arylboronic acids and esters (referred to collectively as arylboronic compounds) are commonly used intermediates in the synthesis of pharmaceuticals but pose a challenge for chemical syntheses because they are often positive for bacterial mutagenicity in vitro.
Melisa J, Masuda-Herrera, Krista L, Dobo, Michelle O, Kenyon, Julia D, Kenny, Sheila M, Galloway, Patricia A, Escobar, M Vijayaraj, Reddy, Robert A, Jolly, Alejandra, Trejo-Martin, Caren, Brown, Marie, Mckeon, Megan, Young, Shannon, Bruce, Kamala, Pant, Aparajita, Dutta, Rohan, Kulkarni, Joel P, Bercu   +16 more
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