Results 31 to 40 of about 1,946 (157)

Fitness Advantage of mcr-1–Bearing IncI2 and IncX4 Plasmids in Vitro

Frontiers in Microbiology, 2018
The objective of this study was to assess the impact of diverse plasmids bearing colistin resistance gene mcr-1 on host fitness. Forty-seven commensal E.
Renjie Wu, Ling-xian Yi, Lin-feng Yu, Jing Wang, Yiyun Liu, Xiaojie Chen, Luchao Lv, Jun Yang, Jian-Hua Liu   +8 more
doaj   +1 more source

Formation, Transmission, and Dynamic Evolution of a Multidrug-Resistant Chromosomally Integrated Plasmid in Salmonella Spp.

Frontiers in Microbiology, 2022
IncHI2 plasmids, possessing high flexibility and genetic plasticity, play a vital role in the acquisition and transmission of resistance determinants. Polymorphic mobile genetic elements (MGEs) generated by a chromosomally integrated IncHI2 plasmid in an
Man-Xia Chang, Man-Xia Chang, Jing Zhang, Jin-Fei Zhang, Xiao-Min Ding, Yang Lu, Jie Zhang, Ruichao Li, Hong-Xia Jiang, Hong-Xia Jiang   +9 more
doaj   +1 more source

Dissemination of carbapenemase‐producing Enterobacteriaceae and associated resistance determinants through global food systems

Comprehensive Reviews in Food Science and Food Safety, Volume 22, Issue 4, Page 2706-2727, July 2023., 2023
Abstract Antimicrobial agents are a critical component of modern healthcare systems, fulfilling a core function in patient care and improving individual patient outcomes and consequently overall public health. However, the efficacy of antimicrobial interventions is being consistently eroded by the emergence and dissemination of various antimicrobial ...
Richard Harding‐Crooks, Darren Smith, Séamus Fanning, Edward M. Fox   +3 more
wiley   +1 more source

Genetic Features of Plasmid- and Chromosome-Mediated mcr-1 in Escherichia coli Isolates From Animal Organs With Lesions

Frontiers in Microbiology, 2021
The genomic context of the mcr-1 gene in Escherichia coli from animal feces has been widely reported. However, less is known about the mcr-1-carrying plasmid characteristics and other functional regions of Escherichia coli isolates from animal organs ...
Zengyuan Liu, Yingqiu Liu, Wei Xi, Shuangshi Liu, Jia Liu, Hailong Mu, Beibei Chen, Hao He, Yunpeng Fan, Wuren Ma, Weimin Zhang, Mingzhe Fu, Juan Wang, Xiaoping Song   +13 more
doaj   +1 more source

Genetic Analysis of mcr-1-Carrying Plasmids From Gram-Negative Bacteria in a Dutch Tertiary Care Hospital: Evidence for Intrapatient and Interspecies Transmission Events

Frontiers in Microbiology, 2021
The role of plasmids in the complex pandemic of antimicrobial resistance is increasingly being recognized. In this respect, multiple mobile colistin resistance (mcr) gene-carrying plasmids have been described.
Nikolaos Strepis, Anne F. Voor in ’t holt, Margreet C. Vos, Willemien H. A. Zandijk, Astrid P. Heikema, John P. Hays, Juliëtte A. Severin, Corné H. W. Klaassen   +7 more
doaj   +1 more source

High Genetic Plasticity in Multidrug-Resistant Sequence Type 3-IncHI2 Plasmids Revealed by Sequence Comparison and Phylogenetic Analysis [PDF]

Antimicrobial Agents and Chemotherapy, 2018
ABSTRACT We report a novel fusion plasmid, pP2-3T, cointegrating sequence type 3 (ST3)-IncHI2 with an IncFII plasmid backbone mediating multidrug resistance (MDR) and virulence. Phylogenetic analysis and comparative genomics revealed that pP2-3T and other MDR ST3-IncHI2 plasmids clustered together, representing a unique IncHI2 ...
Liang-Xing, Fang, Xing-Ping, Li, Guo-Hui, Deng, Shu-Min, Li, Run-Shi, Yang, Zuo-Wei, Wu, Xiao-Ping, Liao, Jian, Sun, Ya-Hong, Liu   +8 more
openaire   +2 more sources

Whole Genome Sequencing and Characteristics of mcr-1–Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B

Frontiers in Microbiology, 2020
Porcine Escherichia coli ST131 isolates are scarcely documented. Here, whole genome sequencing and core genome (CG) and plasmidome analysis of seven isolates collected from diarrheic piglets and four from pork meat were performed.
Saskia-Camille Flament-Simon, Saskia-Camille Flament-Simon, María de Toro, Azucena Mora, Azucena Mora, Vanesa García, Vanesa García, Isidro García-Meniño, Isidro García-Meniño, Dafne Díaz-Jiménez, Dafne Díaz-Jiménez, Alexandra Herrera, Jorge Blanco, Jorge Blanco   +13 more
doaj   +1 more source

Molecular antibiotic resistance mechanisms and co-transmission of the mcr-9 and metallo-β-lactamase genes in carbapenem-resistant Enterobacter cloacae complex

Frontiers in Microbiology, 2022
Carbapenem-resistant Enterobacter cloacae complex (CRECC) has increasingly emerged as a major cause of healthcare-associated infections, with colistin being one of the last-resort antibiotics of treatment.
Shan Jiang, Shan Jiang, Xiaoyu Wang, Xiaoyu Wang, Haidong Yu, Jisheng Zhang, Jianmin Wang, Jie Li, Xinhui Li, Kewang Hu, Kewang Hu, Xue Gong, Xuemei Gou, Yang Yang, Chunjiang Li, Xiaoli Zhang   +15 more
doaj   +1 more source

Genome Sequence of the Thermotolerant Foodborne Pathogen Salmonella enterica Serovar Senftenberg ATCC 43845 and Phylogenetic Analysis of Loci Encoding Increased Protein Quality Control Mechanisms

mSystems, 2017
Salmonella enterica subsp. enterica bacteria are important foodborne pathogens with major economic impact. Some isolates exhibit increased heat tolerance, a concern for food safety.
Scott V. Nguyen, Gregory P. Harhay, James L. Bono, Timothy P. L. Smith, Dayna M. Harhay   +4 more
doaj   +1 more source

A Trade-Off for Maintenance of Multidrug-Resistant IncHI2 Plasmids in Salmonella enterica Serovar Typhimurium through Adaptive Evolution

mSystems, 2022
The current idea that compensatory evolution processes can account for the “plasmid paradox” phenomenon associated with the maintenance of large costly plasmids in host bacteria has attracted much attention. Although many compensatory mutations have been discovered through various plasmid-host bacterial evolution experiments, the basis of the ...
Jin-Fei Zhang, Liang-Xing Fang, Man-Xia Chang, Ming Cheng, Hui Zhang, Teng-Fei Long, Qian Li, Xin-lei Lian, Jian Sun, Xiao-Ping Liao, Ya-Hong Liu   +10 more
openaire   +3 more sources