Incretin-Related Pathology and Serum Exosome Detection in Experimental Alcohol-Related Brain Damage [PDF]
BiomoleculesAlcohol’s chronic neurotoxic and degenerative effects mediate alcohol-related brain damage (ARBD), which is marked by neurobehavioral, cognitive, and motor deficits.
Suzanne M. de la Monte +2 more
doaj +2 more sources
Comparative effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors and human glucagon-like peptide-1 (GLP-1) analogue as add-on therapies to sulphonylurea among diabetes patients in the Asia-Pacific region: a systematic review [PDF]
, 2014 The prevalence of diabetes mellitus is rising globally, and it induces a substantial public health burden to the healthcare systems. Its optimal control is one of the most significant challenges faced by physicians and policy-makers.
A Juutilainen +58 more
core +14 more sources
Models for Incretin Research: From the Intestine to the Whole Body [PDF]
Endocrinology and Metabolism, 2016 Incretin hormones are produced by enteroendocrine cells (EECs) in the intestine in response to ingested nutrient stimuli. The incretin effect is defined as the difference in the insulin secretory response between the oral glucose tolerance test and an ...
Tae Jung Oh
doaj +1 more source
Mechanisms of the incretin effect in subjects with normal glucose tolerance and patients with type 2 diabetes. [PDF]
PLoS ONE, 2013 The incretin effect on insulin secretion was investigated in 8 subjects with type 2 diabetes (T2D) and 8 with normal glucose tolerance (NGT), using 25, 75, and 125 g oral glucose tolerance tests (OGTT) and isoglycemic intravenous glucose infusions (IIGI).
Andrea Mari +5 more
doaj +1 more source
Incretin‐based therapies [PDF]
Journal of Diabetes, 2012 AbstractIncretin‐based therapies have established a foothold in the diabetes armamentarium through the introduction of oral dipeptidyl peptidase‐4 inhibitors and the injectable class, the glucagon‐like peptide‐1 receptor agonists. In 2009, the American Diabetes Association and European Association for the Study of Diabetes authored a revised consensus ...
Stonehouse, Anthony H +2 more
openaire +2 more sources
AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration. [PDF]
PLoS ONE, 2013 The precise role of AMP-activated protein kinase (AMPK), a target of metformin, in pancreatic β cells remains controversial, even though metformin was recently shown to enhance the expression of incretin receptors (GLP-1 and GIP receptors) in pancreatic ...
Kazuki Tajima +13 more
doaj +1 more source
Applied Phycology, 2021 In traditional medicine marine extracts are extensively used as therapies for diabetes. With the increasing rate of incidence of type 2 diabetes mellitus and rising cost of treatments, we investigated the anti-diabetic properties of extracts of common ...
Danielle Calderwood +9 more
doaj +1 more source
Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches
Biology, 2020 Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from the gut upon nutrient stimulation and regulate postprandial metabolism.
Geke Aline Boer, Jens Juul Holst
doaj +1 more source
The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism
Frontiers in Endocrinology, 2022 Incretin hormones play an important role in the regulation of glucose homeostasis through their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main incretins
Melinda Danowitz +2 more
doaj +1 more source
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
JCI Insight, 2023 In youths with obesity, the gut hormone potentiation of insulin secretion — the incretin effect — is blunted. We explored the longitudinal impact of the incretin effect during pubertal transition on β cell function and insulin sensitivity.
Alfonso Galderisi +8 more
doaj +1 more source