Results 91 to 100 of about 21,748 (299)

The incretin concept today [PDF]

Diabetologia, 1979
1. The insulinogenic factor of the gastrointestinal mucosa named "incretin" is only one part of the complex enteroinsular axis. --2. Of the chemically defined gastrointestinal hormones GIP is the strongest incretin candidate. --3. Because of the dual function of GIP as gastrone and insulinotropic substance several safeguards against GIP-mediated ...
openaire   +2 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Type 2 diabetes mellitus: time to change the concept

Сахарный диабет, 2013
Diabetes mellitus is a heterogeneous group of diseases that, although unified by a number of characteristics, require a differential thera- peutic approach.
Shmuel Levit, Yury Ivanovich Filippov, A S Gorelyshev   +2 more
doaj   +1 more source

Obesity without diabetes: the role of hormonal regulation

Терапевтический архив, 2020
Aim.Obese patients without diabetes present an interesting phenotype to explore protective mechanisms against type 2 diabetes (T2D) development. In our study we looked for specific hormonal features of obese patients without T2D. Materials and methods.
E. A. Shestakova, I. A. Sklyanik, A. S. Panevina, L. V. Nikankina, M. V. Shestakova, I. I. Dedov   +5 more
doaj   +1 more source

Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. [PDF]

, 2013
Controversy exists regarding the potential regenerative influences of incretin therapy on pancreatic β-cells versus possible adverse pancreatic proliferative effects.
Atkinson, Mark, Butler, Alexandra E, Butler, Peter C, Campbell-Thompson, Martha, Dawson, David W, Gurlo, Tatyana   +5 more
core   +2 more sources

Glucagon‐like peptide‐1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions

British Journal of Pharmacology, EarlyView.
Abstract Gastric inhibitory polypeptide (GIP)/Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are increasingly prescribed for the management of obesity and type 2 diabetes, yet research pertinent to their effects on muscle health is limited. Considering the central role of muscle strength as a sarcopenia component, this article summarizes emerging ...
Konstantinos Prokopidis
wiley   +1 more source

The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury

Pharmaceuticals
Traumatic brain injury (TBI), which is a global public health concern, can take various forms, from mild concussions to blast injuries, and each damage type has a particular mechanism of progression.
Anja Harej Hrkać, Kristina Pilipović, Andrej Belančić, Lea Juretić, Dinko Vitezić, Jasenka Mršić-Pelčić   +5 more
doaj   +1 more source

Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus

Сахарный диабет, 2013
For the past several years, a number of studies addressed glucagon and its role in glycemic homeostasis and the development of diabetes mellitus. Current review discusses basic developmental stages of pancreatic islets with special regard for the ...
Nina Alexandrovna Petunina, Lyubov' Valentinovna Trukhina, Elena Igorevna Sinicyna, Marina Vladimirovna Shestakova   +3 more
doaj   +1 more source

Organoprotective effects of glucagon-like peptide-1 receptor agonists with regard to findings of evidencebased cardiovascular safety studies

Медицинский совет, 2020
The article discusses the potential opportunities for impact of antidiabetic drugs from the group of glucagon-like peptide-1 (GLP- 1) receptor agonists on the risks of development and progression of cardiovascular complications in patients with type 2 ...
Yu. Sh. Khalimov, V. G. Kuzmich
doaj   +1 more source

From narratives to numbers and back: Assessing the psychosocial aspects of diabetes in the era of high technology with emerging qualitative and quantitative methodologies

Diabetic Medicine, EarlyView.
Abstract Aims Rapid changes in diabetes therapy combined with limitations of traditional methodological approaches challenge the field of psychosocial research to adequately capture the experiences of people with diabetes. This narrative review provides an overview of emerging qualitative and quantitative approaches that can advance the study of ...
Dominic Ehrmann, Eloise Litterbach, Sonya Deschenes, Rita Forde, Norbert Hermanns, Maaike Horsselenberg, Mandy Jansen, Amy McInerney, Eimear Morrissey, Andreas Schmitt, Uffe Søholm, Giesje Nefs   +11 more
wiley   +1 more source