Metformin treatment for diabetes mellitus correlates with progression and survival in colorectal carcinoma [PDF]
, 2020 BACKGROUND: Diabetes mellitus is unfavorably associated with cancer risk. The purpose of this multi-disciplinary project was to evaluate a possible association of diabetes mellitus and other comorbidities and their treatment with progression of ...
Brown, Robert E. +10 more
core +1 more source
The incretin concept today [PDF]
Diabetologia, 1979 1. The insulinogenic factor of the gastrointestinal mucosa named "incretin" is only one part of the complex enteroinsular axis. --2. Of the chemically defined gastrointestinal hormones GIP is the strongest incretin candidate. --3. Because of the dual function of GIP as gastrone and insulinotropic substance several safeguards against GIP-mediated ...
openaire +2 more sources
Incretins in patients with rheumatoid arthritis
Arthritis Research & Therapy, 2017 BackgroundThe precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. In the present study, we determined whether the incretin-insulin axis and incretin effect are disrupted in patients ...
B. Tejera-Segura +9 more
semanticscholar +1 more source
Recent advances and future perspective in microbiota and probiotics [PDF]
, 2015 Recent studies have highlighted the critical 1 role of intestinal microbes on health. This special issue covers a range of diverse topics related to microbiota and probiotic in gut health and disease, thus highlighting the potential beneficial role ...
Alvarez, Gladis Susana +5 more
core +2 more sources
The role for saxagliptin within the management of type 2 diabetes mellitus: an update from the 2010 European Association for the Study of Diabetes (EASD) 46th annual meeting and the American Diabetes Association (ADA) 70th scientific session [PDF]
, 2010 Saxagliptin is a potent, selective DPP4 inhibitor. Highlights from abstracts presented at the 2010 meetings of the European Association for the Study of Diabetes and the American Diabetes Association include studies and analyses that shed light on the ...
Pablo J Aschner
core +1 more source
Understanding the Incretin Effect [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2011 It is well known that the incretin effect contributes as much as half of the insulin secretory response to oral glucose load and that this effect is reduced along with worsening glucose tolerance in those with type 2 diabetes. Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the two primary incretin hormones secreted from ...
openaire +2 more sources
Potential Effect of DPP-4 Inhibitors Towards Hepatic Diseases and Associated Glucose Intolerance
Diabetes, Metabolic Syndrome and Obesity, 2022 Ashwani Sharma,1 Tarun Virmani,1 Anjali Sharma,2 Vaishnavi Chhabra,1 Girish Kumar,1 Kamla Pathak,3 Abdulsalam Alhalmi4 1School of Pharmaceutical Sciences, MVN University, Palwal, Haryana, 121105, India; 2Freelancer, Pharmacovigilance Expert, Uttar ...
Sharma A +6 more
doaj
Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice [PDF]
, 2015 10.1038/srep08731Scientific ...
Amoyo, Arlaine Anne +11 more
core +1 more source
Role of incretin based therapies in the treatment of diabetic kidney disease
Сахарный диабет, 2018 Diabetic kidney disease (DKD), a serious microvascular complication of diabetes mellitus is a leading cause of end-stage renal disease and is associated with an increased risk of cardiovascular morbidity and mortality.
Paola Fioretto, Andrea Frascati
doaj +1 more source
Lipotoxicity impairs incretin signalling [PDF]
Diabetologia, 2012 The incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic peptide are secreted by enteroendocrine cells and augment glucose-induced insulin secretion in response to food ingestion in a glucose-dependent manner. This mechanism forms the basis for incretin-based therapies in type 2 diabetes.
openaire +2 more sources