An evaluation of the fixed concentration procedure for assessment of acute inhalation toxicity [PDF]
, 2018 Acute inhalation studies are conducted in animals as part of chemical hazard identification and for classification and labelling. Current methods employ death as an endpoint (OECD TG403 and TG436) while the recently approved fixed concentration procedure
Griffiths, David +8 more
core +2 more sources
An efficient approach to homochiral indane nucleosides
Tetrahedron: Asymmetry, 2009 A series of new chiral 6-substituted purinyl and 8-aza-purinyl carbonucleosides based on indanol were synthesized from the commercially available (1R,2S)-1-amino-2-indanol and (1S,2R)-1-amino-2-indanol based on a well-known methodology.
Ugliarolo, Esteban Ariel +3 more
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Computer Aided Aroma Design. II. Quantitative structure-odour relationship [PDF]
, 2008 Computer Aided Aroma Design (CAAD) is likely to become a hot issue as the REACH EC document targets many aroma compounds to require substitution. The two crucial steps in CAMD are the generation of candidate molecules and the estimation of properties ...
Floquet, Pascal +5 more
core +2 more sources
Quantitative and Stereoisomeric Determination of Light Biomarkers in Crude Oil and Coal Samples [PDF]
, 1998 Indans and tetralins are considered biological markers (biomarkers). These C9-C11 hydrocarbons are present in small amounts in organic geological samples. Methyl substituted indans or tetralins may possess a stereogenic center (carbon).
Armstrong, Daniel W. +3 more
core +2 more sources
THE MEANING OF RELATIONSHIP QUALITY BY THE BUSINESS LEADERS: RESULTS OF A QUALITATIVE STUDY [PDF]
, 2021 The aim of this research is to investigate the perception of the importance of relationship quality between the organisational leaders and their subordinates.
Jacquemod, Juija
core +3 more sources
EURL ECVAM strategy to replace, reduce and refine the use of animals in the assessment of acute mammalian systemic toxicity [PDF]
, 2014 Information on acute systemic toxicity represents a standard requirement within several pieces of chemicals legislation in the EU. One of the main drivers of conducting the test is classification and labelling.
BURTON JULIEN +5 more
core +1 more source
Thermal and catalytic pyrolysis of a real mixture of post-consumer plastic waste: An analysis of the gasoline-range product [PDF]
, 2022 In this work, the thermal and catalytic pyrolysis of different types of plastic waste and a real mixture were investigated in a fixed-bed reactor over different catalysts (CaO, MgO, HY, HZSM-5). Important differences in gas, liquid, and solid yields were
Blázquez, Gabriel +5 more
core +1 more source
Nouveaux corps odorants dans le domaine des muscs polycycliques [PDF]
, 1992 Polyalkyl-tetralins and -indans are well known as starting materials for polycyclic musks obtained by Friedel-Crafts acylation. If, instead, such hydrocarbons are subjected to benzylic (electrochemical) oxidation, new musks are obtained.
Baudin, Josiane +2 more
core +2 more sources
Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti-inflammatory molecule PH46A [PDF]
Journal of Pharmacy and Pharmacology, 2020 Abstract Objectives PH46A (1) demonstrates significant anti-inflammatory activity in phenotypic models but its mechanism and site of action have been elusive. Current study focused on the bioactivity of PH46 (2) and related novel indane dimers (6-10) to investigate the impact of changes in ...
Kit Chan +6 more
openaire +6 more sources
Bioorganic ChemistryThe indane scaffold, prevalent in bioactive natural products, underpins numerous therapeutics. Our group developed a series of 1,2-indane dimers, including PH46A (9), for inflammatory and autoimmune diseases. This study details the design, synthesis and characterisation of 21 compounds, including 2,2-disubstituted indanones (16a-16h), indanols (17a-17h)
Tao, Zhang +9 more
openaire +2 more sources