Results 21 to 30 of about 10,572 (203)
Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein [PDF]
, 2018 In this report, we present a new benzoxazole derivative endowed with inhibitory activity against the HIV-1 nucleocapsid protein (NC). NC is a 55-residue basic protein with nucleic acid chaperone properties, which has emerged as a novel and potential ...
Botta, Maurizio +9 more
core +3 more sources
Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles [PDF]
Molecules, 2016 A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography.
Mei-Huey Lin +7 more
openaire +3 more sources
Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds [PDF]
, 2018 Oxidative stress may be the major cause of induction of Shiga toxin-converting (Stx) prophages from chromosomes of Shiga toxin-producing Escherichia coli (STEC) in human intestine.
Bloch, Sylwia +11 more
core +1 more source
Angewandte Chemie, EarlyView.We present a new class of electronically and sterically hindered N‐heterocyclic carbenes, referred to as bridged cyclic (amino)ylide carbene (bCAYC), where 9H‐pyrrolo[1,2‐a]indole acted as carbene core and diaryl sulfonium as ylide partner. Corresponding bCAYC‐Au(I) exhibits a weak secondary intramolecular Au···H−C(sp3) interaction as a secondary ...
Sourav Sekhar Bera +6 more
wiley +2 more sources
Molecules, 2017 Indazole is considered a very important scaffold in medicinal chemistry. It is commonly found in compounds with diverse biological activities, e.g., antimicrobial and anti-inflammatory agents.
Jaime Pérez-Villanueva +11 more
doaj +1 more source
In vivo and In vitro Anti-Inflammatory Activity of Indazole and Its Derivatives [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: The inflammatory response is closely intertwined with the process of repair. However in some diseases the inflammatory response may be exaggerated and sustained without apparent benefit and even with severe adverse complications.
Chakrapani Cheekavolu, M. Muniappan
doaj +1 more source
7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures [PDF]
, 1995 7-Nitro indazole (25–100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system
Dzoljic, E. (Eleonora) +2 more
core +1 more source
IUCrData, 2018 In the title compound, C14H11N3O2, the indazole portion is planar to within 0.022 (2) Å and subtends a dihedral angle of 65.87 (7)° with the pendant benzene ring.
Mohamed Mokhtar Mohamed Abdelahi +4 more
doaj +1 more source
2-(4-Methylphenyl)-2H-indazole [PDF]
Acta Crystallographica Section E Structure Reports Online, 2010 The title compound, C(14)H(12)N(2), was synthesized by the reaction of 4-methyl-N-(2-nitro-benz-yl)aniline with tin(II) chloride dihydrate in ethanol at 313 K. The indazole ring system is almost planar with a dihedral angle of 1.58 (10)° between the rings, whereas the plane of the attached p-tolyl substituent shows a dihedral angle of 46.26 (5)° with ...
Xingqin Zhou +2 more
openaire +3 more sources
One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade
Angewandte Chemie, EarlyView.A sustainable electrochemical cascade enables the one‐pot synthesis of regioselectively halogenated N‐aryl amides from readily available amines and acyl halides under mild conditions. The method merges amidation and C─H halogenation in a single operational step, delivering broad substrate scope, high selectivity, and scalability, and provides an ...
Sudipta Ponra +8 more
wiley +2 more sources