Results 51 to 60 of about 10,572 (203)

Ethyl 3-[6-(4-methoxybenzenesulfonamido)-2H-indazol-2-yl]propanoate monohydrate

Acta Crystallographica Section E, 2013
In the title compound, C19H21N3O5S·H2O, the central indazole system is essentially planar (r.m.s. deviation = 0.012 Å), while both the benzene ring and the mean plane defined by the non-H atoms of the ethyl propionic ester unit (r.m.s ...
Najat Abbassi, El Mostapha Rakib, Abdellah Hannioui, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Regioselective alkylation of a versatile indazole: Electrophile scope and mechanistic insights from density functional theory calculations

Beilstein Journal of Organic Chemistry
Herein, we report a pair of regioselective N1- and N2-alkylations of a versatile indazole, methyl 5-bromo-1H-indazole-3-carboxylate (6) and the use of density functional theory (DFT) to evaluate their mechanisms. Over thirty N1- and N2-alkylated products
Pengcheng Lu, Luis Juarez, Paul A. Wiget, Weihe Zhang, Krishnan Raman, Pravin L. Kotian   +5 more
doaj   +1 more source

New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. [PDF]

, 2019
Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the endocannabinoid system and as novel pharmacotherapies, but are now highly abused.
Diao, Xingxing, Huestis, Marilyn A.
core   +2 more sources

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors [PDF]

, 2016
There is an urgent and unmet medical need for new antibacterial drugs that tackle infections caused by multidrug-resistant (MDR) pathogens. During the course of our wider efforts to discover and exploit novel mechanism of action antibacterials, we have ...
Best, Stuart, Cao, Sha, Charrier, Cédric, Cheung, Jonathan, Cooper, Ian R., Craighead, Mark, Forward, Henry, Gault, Zoe, Hughes, Diarmaid, Kirkham, James, Maclean, John, McCarroll, Andrew J., McGarry, David, Metzger, Richard, Moyo, Emmanuel, Nelson, Gary, Pichowicz, Mark, Ratcliffe, Andrew J., Salisbury, Anne-Marie, Savage, Victoria J., Stokes, Neil R., Walker, Rolf, Warrilow, Catherine   +22 more
core   +1 more source

Ethyl 2-(6-nitro-1H-indazol-1-yl)acetate

IUCrData, 2017
The asymmetric unit of the title compound, C11H11N3O4, comprises two independent molecules, both of which display positional disorder of their ethyl chains in 0.868 (4):0.132 (4) and 0.839 (4):0.161 (4) ratios. The packing is directed by a combination of
Mohamed Mokhtar Mohamed Abdelahi, Youness El Bakri, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Regiospecific synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles via photochemically generated nitrile imine intermediates [PDF]

, 2014
The synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles was achieved under photochemical conditions. This simple and mild one-step reaction provides regiospecific access to 2,4,5-substituted 1,2,3-triazoles via a nitrile imine ...
Harris, Robert, Jamieson, Craig, Stewart, Sam   +2 more
core   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, EarlyView.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Harnessing polarisation transfer to indazole and imidazole through signal amplification by reversible exchange to improve their NMR detectability [PDF]

, 2017
The signal amplification by reversible exchange (SABRE) approach has been used to hyperpolarise the substrates indazole and imidazole in the presence of the co-ligand acetonitrile through the action of the precataysts [IrCl(COD)(IMes)] and [IrCl(COD ...
Adams, Adams, Atkinson, Barskiy, Barskiy, Braun, Burns, Clavier, Cowley, Crozier, Duckett, Dücker, Eisenschmid, Eshuis, Eshuis, Eshuis, Fekete, Fekete, Fernandez Diaz-Rullo, Gaikwad, Green, Grimmett, Ivanov, Jiang, Knecht, Korchak, Lloyd, Lloyd, Mewis, Mewis, Moreno, Morrison, Noggle, Olaru, Pravdivtsev, Pravdivtsev, Rayner, Shchepin, Thangadurai, Tolman, Vold, Vold, Walker, Weerdenburg, Zeng, Zhang   +45 more
core   +2 more sources

Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways

European Journal of Organic Chemistry, EarlyView.
Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian, Andrea Serafino, Luc Neuville, Géraldine Masson   +3 more
wiley   +1 more source

Activity-based detection of consumption of synthetic cannabinoids in authentic urine samples using a stable cannabinoid reporter system [PDF]

, 2017
Synthetic cannabinoids (SCs) continue to be the largest group of new psychoactive substances (NPS) monitored by the European Monitoring Center of Drugs and Drugs of Abuse (EMCDDA).
Auwärter, Volker, Cannaert, Annelies, Franz, Florian, Stove, Christophe   +3 more
core   +2 more sources