Results 121 to 130 of about 9,369 (148)
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Oral administration of indole-3-lactic acid alleviates activity-based anorexia in female mice
NeuropharmacologyAnorexia nervosa (AN) is a severe psychiatric disorder characterized by extreme dietary restriction, pronounced weight loss, and disturbed energy metabolism. In recent years, increasing attention has been given to the role of the gut microbiota and its tryptophan-derived metabolites in modulating host neural function and feeding behavior via the gut ...
Xinyu Tang +7 more
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The Journal of Dermatology
ABSTRACT Psoriasis is a chronic inflammatory skin disease whose pathogenesis involves dysregulation of the skin microbiota. Multiple studies have revealed alterations in microbial community composition between psoriatic lesions and healthy skin.
Yangang Zhang +9 more
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ABSTRACT Psoriasis is a chronic inflammatory skin disease whose pathogenesis involves dysregulation of the skin microbiota. Multiple studies have revealed alterations in microbial community composition between psoriatic lesions and healthy skin.
Yangang Zhang +9 more
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Journal of Agricultural and Food Chemistry
Indole-3-lactic acid (ILA), a gut microbial metabolite, plays an important role in gut health. However, the number of bacterial strains that can produce ILA remains limited. This study investigated the synergistic relationship between Lactiplantibacillus plantarum DX7 and walnut pellicle polyphenols (WPP) for enhancing ILA production.
Qing Wang +7 more
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Indole-3-lactic acid (ILA), a gut microbial metabolite, plays an important role in gut health. However, the number of bacterial strains that can produce ILA remains limited. This study investigated the synergistic relationship between Lactiplantibacillus plantarum DX7 and walnut pellicle polyphenols (WPP) for enhancing ILA production.
Qing Wang +7 more
openaire +2 more sources
Brain, Behavior, and Immunity
Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and its metabolites, though the specific mechanisms have remained unclear. In our study, we used a multi-omics approach to identify specific microbial strains and metabolites that could potentially mitigate amyloidopathy in 5xFAD mice, a widely used model for AD research.
Hyun, Kim +18 more
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Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and its metabolites, though the specific mechanisms have remained unclear. In our study, we used a multi-omics approach to identify specific microbial strains and metabolites that could potentially mitigate amyloidopathy in 5xFAD mice, a widely used model for AD research.
Hyun, Kim +18 more
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Probiotics and Antimicrobial Proteins
Identifying metabolites produced by probiotic bacteria, also known as metabiotics, is becoming increasingly common due to their anti-inflammatory, anti-obesogenic, and immunomodulatory effects. Postbiotics alongside diet, regulate both physical and mental health, as the microbiota members can interact physically with host cells or through secretion of ...
Muñoz-Olivos Cristina +5 more
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Identifying metabolites produced by probiotic bacteria, also known as metabiotics, is becoming increasingly common due to their anti-inflammatory, anti-obesogenic, and immunomodulatory effects. Postbiotics alongside diet, regulate both physical and mental health, as the microbiota members can interact physically with host cells or through secretion of ...
Muñoz-Olivos Cristina +5 more
openaire +2 more sources
1995
The free-living nitrogen-fixing soil bacterium Azospirillum brasilense Sp7 produces indole-3-acetic acid (IAA) from tryptophan (Trp). Ammonia and oxygen are involved in the processes of IAA production and nitrogen fixation. Oxygen is required during the conversion of Trp to IAA via indole-3-acetamide (IAM).
Tami Bar, Yaacov Okon
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The free-living nitrogen-fixing soil bacterium Azospirillum brasilense Sp7 produces indole-3-acetic acid (IAA) from tryptophan (Trp). Ammonia and oxygen are involved in the processes of IAA production and nitrogen fixation. Oxygen is required during the conversion of Trp to IAA via indole-3-acetamide (IAM).
Tami Bar, Yaacov Okon
openaire +1 more source
Helminth-remodeled microbial indole-3-lactic acid drives AhR-dependent disease tolerance
Abstract Helminths systemically suppress host immunity, yet whether they impose immune tolerance by rewiring host-associated microbial metabolism remains unclear. Here we show that Trichinella spiralis infection remodels intestinal tryptophan metabolism to generate an AhR-dependent ...Ruohang Sun +12 more
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Carbohydrate Polymers
Diet-induced metabolic disorder is a global health concern, and bioactive polysaccharides have been shown to mitigate metabolic disorder by modifying gut microbiota. Polysaccharides from Schizophyllum commune have shown excellent anti-obesity effects, but the specific regulatory mechanisms remain unclear.
Chaomin, Yin +8 more
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Diet-induced metabolic disorder is a global health concern, and bioactive polysaccharides have been shown to mitigate metabolic disorder by modifying gut microbiota. Polysaccharides from Schizophyllum commune have shown excellent anti-obesity effects, but the specific regulatory mechanisms remain unclear.
Chaomin, Yin +8 more
openaire +2 more sources
Placenta
Preeclampsia (PE) is a life-threatening condition that is unique to human pregnancy, and it is a leading cause of maternal and neonatal morbidity and mortality. Currently, the only definitive treatment for PE is delivery of the placenta. Several studies have suggested that the gut microbiota and its derived metabolites may be associated with PE.
Yingying Wei +7 more
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Preeclampsia (PE) is a life-threatening condition that is unique to human pregnancy, and it is a leading cause of maternal and neonatal morbidity and mortality. Currently, the only definitive treatment for PE is delivery of the placenta. Several studies have suggested that the gut microbiota and its derived metabolites may be associated with PE.
Yingying Wei +7 more
openaire +2 more sources
Life Sciences
This study investigates the potential of Bifidobacterium bifidum 1007478 (BB478) and its metabolite indole-3-lactic acid (ILA) in alleviating non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD) and fructose exposure.A zebrafish model of NASH was established by exposure to HFD and fructose.
Chao, Tian +4 more
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This study investigates the potential of Bifidobacterium bifidum 1007478 (BB478) and its metabolite indole-3-lactic acid (ILA) in alleviating non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD) and fructose exposure.A zebrafish model of NASH was established by exposure to HFD and fructose.
Chao, Tian +4 more
openaire +2 more sources