Results 91 to 100 of about 49,383 (204)

Differences in the Profile of Aromatic Metabolites in the Corresponding Blood Serum and Cerebrospinal Fluid Samples of Patients with Secondary Bacterial Meningitis

Metabolites
Background: Secondary (nosocomial) bacterial meningitis remains a serious problem in patients with severe brain damage. The aim of this study was to assess the differences in the aromatic metabolites of tryptophan, phenylalanine, and tyrosine, in serum ...
Alisa K. Pautova, Peter A. Meinarovich, Vladislav E. Zakharchenko, Pavel D. Sobolev, Natalia A. Burnakova, Natalia V. Beloborodova   +5 more
doaj   +1 more source

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Indole-3-Propionic Acid, a Gut Microbiota-Derived Tryptophan Metabolite, Promotes Endothelial Dysfunction Impairing Purinergic-Induced Nitric Oxide Release in Endothelial Cells. [PDF]

Int J Mol Sci
Different gut microbiota-derived metabolites influence cardiovascular function, and, among all, the role of indole-3-propionic acid (IPA), from tryptophan metabolism, shows controversial effects.
Geddo F, Antoniotti S, Gallo MP, Querio G.   +3 more
europepmc   +2 more sources

Review: Pharmacological effects of Capparis spinosa L. [PDF]

, 2016
Medicinal plants have been known as one of the most important therapeutic agents since ancient times. During the last two decades, much attention has been paid to the health-promoting effects of edible medicinal plants, because of multiple beneficial ...
Abraham, Afsharypuor, Ageel, Aggarwal, Aghel, Ahmed, Ahvazi, Aichour, Al-Qura'n, Al-Soqeer, Aliyazicioglu, Allaith, Arena, Argentieri, Asl, Attrey, Banel, Barbera, Barbera, Benzidane, Bhattacharya, Biswas, Bonina, Bouriche, Caboni, Cao, Dillard, Dragicevic, Eddouks, Erdem, Erdogan, Esiyok, Feng, Fici, Fici, Fici, Fici, Francesca, Fu, Fu, Gadgoli, Germano, Giuffrida, Goel, Gull, Gurney, Habtemariam, Habtemariam, Habtemariam, Habtemariam, Higton, Holst, Hu, Huseini, Ihme, Inocencio, Inocencio, Jacobs, Jiang, Kara, Kim, Kulisic-Bilusic, Kulisic-Bilusic, Lam, Lansky, Li, Lin, Macchia, Maire, Matthäus, Miraldi, Mishra, Mishra, Moghaddasi, Mohammad, Mosaddegh, Musallam, Nabavi, Nabavi, Nabavi, Nabavi, Nabavi, Ngameni, Polat, Pérez Pulido, Raskin, Rivera, Rivera, Rodrigo, Romeo, Russo, Saraf, Schraudolf, Schulz, Sen, Sharaf, Sher, Siracusa, Tesi, Tesoriere, Tlili, Tlili, Tlili, Tranchimand, Turgut, Wink, Yang, Yaniv, Yu, Zhang, Zhou, Zhou, Zohary, Çaliş, Çalış   +114 more
core   +1 more source

Progress in Surface‐Enhanced Raman Scattering‐Based Volatile Organic Compounds Detection: Materials, Application, and Prospects

Rare Metals, EarlyView.
ABSTRACT The detection of volatile organic compounds (VOCs) holds significant implications in environmental monitoring and disease diagnosis. Traditional gas detection technologies are constrained by complex operation and high cost, thereby failing to satisfy real‐time detection demands.
Yuening Wang, Lin Qiu, Jian Yu, Wen Ma, Xiaoyu Song, Mingjian Zhang, Yujiao Xie, Aochi Liu, Li Sun, Xiangyu Meng, Jie Lin, Xiaotian Wang   +11 more
wiley   +1 more source

Use of the oral microbiota as screening test to identify children at risk for caries development. A systematic review of longitudinal studies

European Journal of Oral Sciences, EarlyView.
Abstract This study investigated trends in oral microbiota composition (index test) that could indicate potential candidates to identify children at risk for dental caries development compared with visual/tactile examination (reference test). MEDLINE/PubMed, Web of Science, Embase, Scopus, Lilacs, SciELO, and Google Scholar databases were searched up ...
Heitor Sales de Barros Santos, Maria Eduarda Lisboa Pagnussatti, Marisa Maltz, Rodrigo Alex Arthur   +3 more
wiley   +1 more source

Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin [PDF]

, 2012
New tools that allow dynamic visualization of molecular neural events are important for studying the basis of brain activity and disease. Sensors that permit ligand-sensitive magnetic resonance imaging (MRI) are useful reagents due to the noninvasive ...
Arnold, Frances H., Brustad, Eric M., Crook, Nathan C., Jasanoff, Alan, Jung, Sang Taek, Lelyveld, Victor S., Martinez, Francisco M., Scholl, Tomothy J., Snow, Christopher D.   +8 more
core   +2 more sources

Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS‐Induced Colitis

Immunology, EarlyView.
C57BL/6 mice from Charles River Laboratories (CR) have enhanced mucosal immune action relative to C57BL/6 mice from Jackson Laboratories (JAX). CR mice are more susceptible to severe DSS‐induced colitis than JAX mice. Co‐housing transfers colitis susceptibility from CR mice to JAX mice.
Jessica M. Till, Orion D. Brock, Elyza A. Do, Morgan J. Engelhart, Robert W. P. Glowacki, Shaomin Hu, Ansel Hsiao, Ina Nemet, Philip P. Ahern   +8 more
wiley   +1 more source

Exploring the biological impact of bacteria-derived indole compounds on human cell health: Cytotoxicity and cell proliferation across six cell lines

Toxicology Reports
Over the past two decades, research has increasingly focused on the interactions between diet, gut microbiota, and host organisms. Recent evidence suggests that tryptophan, an essential amino acid, can be metabolized by gut microbiota into indoles, which
Alisha Janiga-MacNelly, Maddison Vrazel, Ava E. Roat, Maria Teresa Fernandez-Luna, Ramon Lavado   +4 more
doaj   +1 more source