Results 101 to 110 of about 49,383 (204)

Tryptophan‐Derived Microbial Metabolite Indole‐3‐Acetic Acid Ameliorates Periodontitis Through AhR/CYP1A1‐Mediated Macrophage Polarisation

open access: yesJournal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate the association between tryptophan‐derived microbial metabolites and periodontitis, and to assess whether the differential tryptophan metabolite indole‐3‐acetic acid (IAA) could ameliorate periodontitis and elucidate its potential mechanism.
Shuyu Cheng   +9 more
wiley   +1 more source

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation [PDF]

open access: yesAmerican Journal of Physiology-Endocrinology and Metabolism, 2019
We proposed that circulating metabolites generated by the intestinal microbiota can affect vascular function. One such metabolite, indole 3-propionic acid (IPA), can activate the pregnane X receptor(PXR), a xenobiotic-activated nuclear receptor present in many tissues, including the vascular endothelium.
Vivek Krishna Pulakazhi Venu   +9 more
openaire   +2 more sources

Interplay between gut microbiota and tryptophan metabolism in type 2 diabetic mice treated with metformin

open access: yesMicrobiology Spectrum
Tryptophan (TRP) metabolites have been identified as potent biomarkers for complications of type 2 diabetes mellitus (T2DM). However, it remains unclear whether the therapeutic effect of metformin in T2DM is related to the modulation of TRP metabolic ...
Yvhao Xie   +7 more
doaj   +1 more source

Concentration difference of auxin involved in stem development in soybean

open access: yesJournal of Integrative Agriculture, 2020
Auxin regulates cell division and elongation of the primordial cells through its concentration and then shaped the plant architecture. Cell division and elongation form the internode of soybean and result in different plant heights and lodging resistance.
Zhen-feng JIANG   +6 more
doaj   +1 more source

Separating Myths From Facts About Bread and Health

open access: yesNutrition Bulletin, EarlyView.
ABSTRACT White bread remains a staple food in many countries and global consumption continues to increase. However, there is an increasingly contentious debate, carried out particularly in social media and the popular press, about the adverse effects on health of factory‐produced sliced white bread as opposed to the whole grain breads made with ...
Peter R. Shewry   +5 more
wiley   +1 more source

UGT74D1 is a novel auxin glycosyltransferase from Arabidopsis thaliana. [PDF]

open access: yesPLoS ONE, 2013
Auxin is one type of phytohormones that plays important roles in nearly all aspects of plant growth and developmental processes. The glycosylation of auxins is considered to be an essential mechanism to control the level of active auxins.
Shang-Hui Jin   +7 more
doaj   +1 more source

New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. [PDF]

open access: yes, 2019
Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the endocannabinoid system and as novel pharmacotherapies, but are now highly abused.
Diao, Xingxing, Huestis, Marilyn A.
core   +2 more sources

The Protective Effects of Membrane‐Separated Ripe Pu‐Erh Tea Extracts Against Chronic Alcoholic Liver Injury

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
In this study, we investigated the protective effects of different membrane‐separated ripe Pu‐erh tea on alcohol‐induced liver injury. The result indicated that ripe Pu‐erh tea separated by a 50 nm ceramic membrane (molecular weight < 300 kDa) has the best effect on preventing ALD.
Sibo Zhao   +9 more
wiley   +1 more source

The role of indole metabolites derived from gut microbiota in Parkinson's disease: A comprehensive review

open access: yesBrain Research Bulletin
Emerging evidence suggests that Parkinson’s disease (PD) extends beyond the brain and involves early disturbances along the gut-brain axis. Among the metabolites shaping this communication, bacterial products derived from tryptophan, particularly indole ...
Shuo Meng
doaj   +1 more source

Effects of Probiotic Supplementation on Symptoms and Microbiome Characteristics in Patients With Non‐Celiac Gluten/Wheat Sensitivity: A Randomized Controlled Double‐Blind Trial

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
This randomized, double‐blind, placebo‐controlled trial demonstrated that probiotic supplementation in individuals with non‐celiac gluten/wheat sensitivity improved tolerance to gluten reintroduction in nearly half of participants. The effect was associated with beneficial shifts in gut microbiome composition and function, including enhanced microbial ...
Ilario Ferrocino   +14 more
wiley   +1 more source

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