Marine Drugs, 2015 Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development.
Natalie Netz, Till Opatz
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Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities [PDF]
Marine Drugs, 2021 Novel secondary metabolites from marine macroorganisms and marine-derived microorganisms have been intensively investigated in the last few decades. Several classes of compounds, especially indole alkaloids, have been a target for evaluating biological ...
Joko Tri Wibowo +5 more
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Marine Indole Alkaloids—Isolation, Structure and Bioactivities [PDF]
Marine Drugs, 2021 Indole alkaloids are heterocyclic natural products with extensive pharmacological activities. As an important source of lead compounds, many clinical drugs have been derived from natural indole compounds.
Yong Hu +3 more
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Indole Alkaloids as Biased Opioid Receptor Modulators [PDF]
PharmaceuticalsBackground: Opioid receptors are a commonly used target for treatment of pain conditions. Most opioids used in therapy are linked to adverse effects such as tolerance, dependence, and respiratory depression.
Oliver Grundmann, Allison Henderson
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Molecular cloning and functional characterization of BcTSA in the biosynthesis of indole alkaloids in Baphicacanthus cusia [PDF]
Frontiers in Plant Science, 2023 Baphicacanthus cusia (Nees) Bremek (B. cusia) is an essential traditional Chinese herb that is commonly used to treat colds, fever, and influenza. Indole alkaloids, such as indigo and indirubin, are the primary active constituents of B. cusia. The indole-
Zhiying Guo +7 more
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Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids [PDF]
Marine DrugsFiloviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Leah Liu Wang +6 more
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Modular assembly of indole alkaloids enabled by multicomponent reaction [PDF]
Nature Communications, 2023 Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals. Although methods for the synthesis of indole alkaloids are constantly explored, the direct single-step synthesis of these chemical entities ...
Jiaming Li +4 more
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Indole Alkaloids from Psychoactive Mushrooms: Chemical and Pharmacological Potential as Psychotherapeutic Agents [PDF]
Biomedicines, 2023 Neuropsychiatric diseases such as depression, anxiety, and post-traumatic stress represent a substantial long-term challenge for the global health systems because of their rising prevalence, uncertain neuropathology, and lack of effective pharmacological
Erika Plazas, Nicoletta Faraone
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Halogenated Indole Alkaloids from Marine Invertebrates
Marine Drugs, 2010 This review discusses the isolation, structural elucidation, and biological activities of halogenated indole alkaloids obtained from marine invertebrates.
Patricia Mendonça Pauletti +2 more
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A Systematic Review of Analytical Methods for Quantification of Natural Indole Alkaloids from Catharanthus and Rauvolfia Species [PDF]
Research Journal of Pharmacognosy, 2023 Indole alkaloids are a class of alkaloids enclosing a structural moiety of indole; numerous indole alkaloids also comprise isoprene groups and are thus named terpene indole or secologanin tryptamine alkaloids and have more than 4100 identified diverse ...
Lakshmipriya Murugesan +2 more
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