Results 21 to 30 of about 13,686 (198)
Analgesic monoterpene indole alkaloids from Gelsemium elegans stems
Journal of Holistic Integrative Pharmacy, 2022 Objective: The aim of this study is to search for potent analgesics from the stems of Gelsemium elegans. Methods: Alkaloids were isolated from the samples of G.
Pengfei JIN +7 more
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Química Nova, 2007 Species from genus Aspidosperma (Apocynaceae) are popularly employed to treat various diseases. This genus is characterized by the occurrence of indole alkaloids.
Maria de M. Pereira +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl‐acyl carrier protein (ACP) precursor is rearranged through the action of the S‐adenosyl‐methionine (SAM)‐dependent methyltransferase FshF, to generate a pendant vinyl group.
Sandra A. C. Figueiredo +8 more
wiley +2 more sources
Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization
Angewandte Chemie, EarlyView.The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu +6 more
wiley +2 more sources
Enantioselective Synthesis of Alkaloids from Phenylglycinol-Derived Lactams
Natural Product Communications, 2011 This review is focused on recent synthetic achievements and ongoing work in our laboratory using phenylglycinol-derived oxazolopiperidone lactams as starting materials for the enantioselective synthesis of piperidine-containing alkaloids: madangamines, 2,
Mercedes Amat +4 more
doaj +1 more source
Microbial Hydroxylation of Indole Alkaloids [PDF]
Applied Microbiology, 1964 The hydroxylation of the indole-type alkaloids, yohimbine, α-yohimbine, β-yohimbine, and corynanthine, was achieved with several genera of higher fungi and species of Streptomyces . Microorganisms were found which monohydroxylated these compounds in three different positions.
R E, HARTMAN +3 more
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RHEOLOGICAL PROPERTIES OF INDOLIC ALKALOIDS OBTAINED FROM NATURAL PRODUCTS [PDF]
Romanian Journal of Petroleum & Gas TechnologyIndole chemistry is a fascinating and complex field. The foul-smelling indole molecule is the building block for various natural and chemical products. Moreover, some indole derivatives are vital pharmaceutical products or essential intermediates. Indole
Ana-Maria Neculai +2 more
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Kopsiyunnanines J1 and J2, New Strychnos-type Homo-Monoterpenoid Indole Alkaloids from
Natural Product Communications, 2015 Two new indole alkaloids, kopsiyunnanines J1 and J2, were isolated from Yunnan Kopsia arborea , and their structures were determined by spectroscopic analyses.
Mariko Kitajima +5 more
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Halogenated Indole Alkaloids from Marine Invertebrates
Marine Drugs, 2010 This review discusses the isolation, structural elucidation, and biological activities of halogenated indole alkaloids obtained from marine invertebrates.
Ana Helena Januário +6 more
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New Approaches to Indoles and Indole Alkaloids [PDF]
Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings, 2013 Second only to pyridines, indoles are among the most common aromatic scaffolds present in bioactive molecules. The 5-hydroxy indole moiety alone has currently >10,500 substructure hits Among the many indole-containing alkaloid scaffolds, ergot alkaloids comprise a notable group of natural products of great biological activities. The striking biological
Peter Wipf, Filip Petronijevic
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