Results 21 to 30 of about 297,330 (349)

Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis

open access: yesFrontiers in Pharmacology, 2022
Indole alkaloids are widely distributed in nature and have been particularly studied because of their diverse biological activities, such as anti-inflammatory, anti-tumor, anti-bacterial, and anti-oxidant activities.
Rui Qin   +7 more
doaj   +1 more source

Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective

open access: yesMolecules, 2021
Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities.
Faisal Omar   +6 more
semanticscholar   +1 more source

Indole-Containing Natural Products 2019–2022: Isolations, Reappraisals, Syntheses, and Biological Activities

open access: yesMolecules, 2022
Indole alkaloids represent a large subset of natural products, with more than 4100 known compounds. The majority of these alkaloids are biologically active, with some exhibiting excellent antitumor, antibacterial, antiviral, antifungal, and ...
Syed Muhammad Umer   +3 more
doaj   +1 more source

Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera

open access: yesMolecules, 2021
By the end of the twentieth century, the interest in natural compounds as probable sources of drugs has declined and was replaced by other strategies such as molecular target-based drug discovery.
Afrah E. Mohammed   +6 more
semanticscholar   +1 more source

Natural Indole Alkaloids from Marine Fungi: Chemical Diversity and Biological Activities

open access: yesPharmaceutical Fronts, 2021
The indole scaffold is one of the most important heterocyclic ring systems for pharmaceutical development, and serves as an active moiety in several clinical drugs.
Jiao Li, Chun-Lin Zhuang
doaj   +1 more source

Isolation and Characterization of Compounds from Ochreinauclea maingayi (Hook. f.) Ridsd. (Rubiaceae) with the Aid of LCMS/MS Molecular Networking

open access: yesSeparations, 2023
Phytochemical investigation of the dichloromethane crude extract from the bark of Ochreinauclea maingayi with the aid of LCMS/MS-based molecular networking guided the isolation and accelerated the elucidation of known and new indole alkaloids.
Norfaizah Osman   +9 more
doaj   +1 more source

Enzyme biosensor based on pH‐sensitive field‐effect transistors for assessment of total indole alkaloids content in tissue culture of Rauwolfia serpentina

open access: yesElectrochemical Science Advances, 2022
A laboratory prototype of enzyme biosensor based on pH‐sensitive field‐effect transistors has been created to determine the total content of indole alkaloids in Rauwolfia serpentina tissue culture.
Valentyna Arkhypova   +5 more
doaj   +1 more source

Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook

open access: yesFrontiers in Pharmacology, 2021
Uncaria Hook (UH) is a dry stem with hook of Ucaria plant and is contained in Traditional Japanese and Chinese medicine such as yokukansan, yokukansankachimpihange, chotosan, Gouteng-Baitouweng, and Tianma-Gouteng Yin.
H. Kushida   +2 more
semanticscholar   +1 more source

Analgesic monoterpene indole alkaloids from Gelsemium elegans stems

open access: yesJournal of Holistic Integrative Pharmacy, 2022
Objective: The aim of this study is to search for potent analgesics from the stems of Gelsemium elegans. Methods: Alkaloids were isolated from the samples of G.
Pengfei JIN   +7 more
doaj   +1 more source

Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: Applications to the total synthesis of alkaloids [PDF]

open access: yes, 2008
Enantioselective syntheses of the alkaloids (-)-aurantioclavine, (+)-amurensinine, (-)-lobeline, and (-)- and (+)-sedamine are described. The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in ...
Bagdanoff, Jeffrey T.   +5 more
core   +2 more sources

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