Results 91 to 100 of about 44,829 (223)

Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents : a cross-sectional analysis of two cohorts [PDF]

, 2018
Background: Tryptophan breakdown is an important mechanism in several diseases e.g. inflammation and stress induced inflammation have been associated with the development of depression via enhanced tryptophan breakdown.
Carvalho, Livia A, Clarke, Gerard, Díaz, Ligia Esperanza, Gómez-Martínez, Sonia, Marcos, Ascensión, Michels, Nathalie, Olavarria-Ramirez, Loreto, Widhalm, Kurt   +7 more
core   +2 more sources

Distinct roles of immunoreceptor tyrosine‐based motifs in immunosuppressive indoleamine 2,3‐dioxygenase 1

Journal of Cellular and Molecular Medicine, 2016
The enzyme indoleamine 2,3‐dioxygenase 1 (IDO1) catalyses the initial, rate‐limiting step in tryptophan (Trp) degradation, resulting in tryptophan starvation and the production of immunoregulatory kynurenines.
E. Albini, V. Rosini, M. Gargaro, G. Mondanelli, M. L. Belladonna, M. T. Pallotta, C. Volpi, F. Fallarino, A. Macchiarulo, C. Antognelli, R. Bianchi, C. Vacca, P. Puccetti, U. Grohmann, C. Orabona   +14 more
semanticscholar   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

The Two Sides of Indoleamine 2,3-Dioxygenase 2 (IDO2)

Cells
Indoleamine 2,3-dioxygenase 1 (IDO1) and IDO2 originated from gene duplication before vertebrate divergence. While IDO1 has a well-defined role in immune regulation, the biological role of IDO2 remains unclear.
Chiara Suvieri, Maria Laura Belladonna, Claudia Volpi   +2 more
doaj   +1 more source

Necrostatin-1 Analogues: Critical Issues on the Specificity, Activity and In Vivo Use in Experimental Disease Models [PDF]

, 2012
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation.
Callewaert, N, Cauwels, A, Declercq, W, Degterev, A, DuHadaway, J B, Duprez, L, Goossens, V, Grootjans, S, Libert, C, Nerinckx, W, Prendergast, G C, Roelandt, R, Takahashi, N, Van Hauwermeiren, F, Vandenabeele, P, Yuan, Junying   +15 more
core   +2 more sources

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. [PDF]

, 2019
PurposeGlioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for ...
Kaprealian, Tania, Lee, Mi-Heon, McBride, William H, Nesseler, Jean Philippe, Nickers, Philippe, Niclou, Simone P, Schaue, Dorthe   +6 more
core  

A CD8 T Cell/Indoleamine 2,3-Dioxygenase Axis Is Required for Mesenchymal Stem Cell Suppression of Human Systemic Lupus Erythematosus [PDF]

, 2014
published_or_final_versio
Chen, Wanjun, Chen, Zhiyong, Feng, Xuebing, Gao, Xiang, Konkel, Joanne E, Li, Xia, Lu, Lin, Lu, Liwei, Shi, Songtao, Sun, Lingyun, Wang, Dandan, Zhang, Huayong   +11 more
core   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams, B. Bradley, Clark, Eastman, Eastman, Giles, Gonzalez, Guidetti, Hirumi, J. Rodgers, Jennings, Jennings, Jhamandas, Kamleh, Kennedy, Kennedy, Kennedy, Kennedy, M. P. Barrett, Moffett, Okuda, Okuda, P. G. E. Kennedy, Pepin, Perkins, Pfefferkorn, P  pin, R  z, Sanni, Schroten, Schwarcz, Smith, Sternberg, Stone, Stone, Stone, T. W. Stone, Vincendeau   +37 more
core   +2 more sources