Results 101 to 110 of about 44,829 (223)

The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy

Scientific Reports, 2019
Cell-based therapy using dendritic cells (DC) represents a potent cancer immunotherapy. However, activated DC express indoleamine 2,3-dioxygenase 1 (IDO1), a counter-regulatory and tolerogenic molecule, leading to the inhibition of T cell activation and ...
Rikito Endo, Takashi Nakamura, Kyoko Kawakami, Yusuke Sato, H. Harashima   +4 more
semanticscholar   +1 more source

Porous Organic Frameworks‐Based Nanomaterials in Colorectal Cancer Therapy: From Drug Delivery to Personalized Nano‐Vaccine

Cancer Nexus, EarlyView.
ABSTRACT Colorectal cancer (CRC), as the second most common cause of cancer death worldwide, has seen a significant increase in its incidence rate in recent years. However, the current major clinical treatment methods, such as surgery, chemotherapy and radiotherapy, still have certain limitations and are difficult to achieve a complete cure.
Xiaoyu Song, Hao Zhang, Yinghui Wang, Chao Luo   +3 more
wiley   +1 more source

Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer

Nature Communications
The efficacy of cancer immunotherapy relies on a sufficient amount of functional immune cells. Triple-negative breast cancer lacks enough immune cell infiltration, and adjuvant therapy is necessary to prime anti-tumor immunity.
Binyu Zhu, Ying Cai, Lingli Zhou, Lei Zhao, Jiameng Chen, Xiaoting Shan, Xujie Sun, Qian You, Xiang Gong, Wen Zhang, Helen He Zhu, Pengcheng Zhang, Yaping Li   +12 more
doaj   +1 more source

Dendritic-Cell (DC)-Based Immunotherapy: Tumor Endothelial Marker 8 (TEM8) Gene Expression of DC Vaccines Correlates with Clinical Outcome [PDF]

, 2008
\ud Previous studies have shown that tumor-endothelial markers (TEMs) are upregulated in immunosuppressive, pro-angiogenic dendritic cells (DCs) found in tumor microenvironments. \ud We reported that pro-angiogenic monocyte-derived DCs (Mo-DCs), utilized
Bolli, Elisabetta, Ridolfi, R., Venanzi, F.M.   +2 more
core  

Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia

, 2013
Background: Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia.
Bode-Böger, S.M. (Stefanie), Kielstein, J.T. (Jan), Kovesdy, C.P. (Csaba), Kümpers, P. (Philipp), Martens-Lobenhoffer, J. (Jens), Meurs, M. (Matijs) van, Padberg, J. (Jan), Zijlstra, J.G. (Jan)   +7 more
core   +1 more source

Mesenchymal stem cells for management of rheumatoid arthritis : immune modulation, repair or both? [PDF]

, 2018
The authors are grateful for support to their research from Arthritis Research UK (grants 19271, 19429, 19667, 20050, 20775) and the Medical Research Council (grant no.
Ansboro, Sharon, de Bari, Cosimo, Roelofs, Anke J.   +2 more
core   +1 more source

Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase 1 Influenced the Age Onset of Parkinson's Disease.

Frontiers in Bioscience, 2020
BACKGROUND Earlier studies reported alterations of the kynurenine (KYN) pathway of tryptophan (TRP) metabolism in Parkinson's disease (PD). The first rate-limiting enzymes indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase were observed ...
N. Török, Rita Maszlag-Török, K. Molnár, Z. Szolnoki, F. Somogyvári, K. Boda, Masaru Tanaka, P. Klivényi, L. Vécsei   +8 more
semanticscholar   +1 more source

Mechanisms of Resistance to Cancer Immunotherapy: A Host–Tumor Interaction Perspective; A Review Article

Cancer Nexus, EarlyView.
Mechanisms of resistance to cancer immunotherapy from a host–tumor interaction perspective. The central tumor cell is protected by multiple resistance mechanisms, including genetic mutations, epigenetic modifications, and metabolic alterations. The immunosuppressive tumor microenvironment features myeloid‐derived suppressor cells (MDSCs), regulatory T ...
Mohammed Elmujtba Adam Essa, Hamid Noori, Abdelkareem A. Ahmed   +2 more
wiley   +1 more source

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

Frontiers in Cellular Neuroscience, 2020
ObjectiveOur study was designed to investigate whether the indoleamine-2,3-dioxygenase (IDO)-mediated kynurenine/tryptophan (KYN/TRP) pathway participates in the development of emotional deficits from ethanol addiction/withdrawal mice.MethodsThe ...
Xi Jiang, Xi Jiang, Qian Lin, Lexing Xu, Ziwei Chen, Qizhi Yan, Lei Chen, Xuefeng Yu   +7 more
doaj   +1 more source

B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women. [PDF]

, 2014
BACKGROUND: B7 costimulatory molecules are expressed on antigen presenting cells (APCs) and are important regulators of T cell activation. We investigated the role of the B7 family of costimulatory molecules in the development of the systemic maternal ...
A Hutloff, AJ Coyle, Anna Bajnok, B Santner-Nanan, C Herve, CA Chambers, CD Gimmi, DH Munn, Enikő Grozdics, ES Taglauer, G Toldi, G Toldi, G Toldi, Gergely Toldi, Gábor Veres, István Ilisz, János Rigó, KJ Swartz, L Vecsei, L Vécsei, LP Jin, László Berta, László Vécsei, MG Petroff, Péter Klivényi, S Saito, S Wang, Tivadar Tulassay, U Grohmann, U Grohmann, Y Mándi   +30 more
core   +2 more sources